Abstract:
:The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements, insulin sensitivity/resistance, and lipid and lipoprotein concentrations at birth. Fifty-three term, appropriate-for-gestational-age, Caucasian newborns together with their respective mothers participated in a cross-sectional study. Sixty-six percent of mothers and neonates carried the A allele (being AA or AT). TT mothers gained less weight during pregnancy, but non-significant maternal gene influence was found for neonatal bodyweight, body mass index, or ponderal index. Neonates from AA + AT mothers showed lower glucose, insulin, and homeostatic model assessment insulin resistance (HOMA-IR) but higher homeostatic model assessment insulin sensitivity (HOMA-IS) and homocysteine than neonates whose mothers were TT. AA + AT neonates had higher insulin and HOMA-IR than TT. The genotype neonatal × maternal association was tested in the following four groups of neonates: TT neonates × TT mothers (nTT × mTT), TT neonates × AA + AT mothers (nTT × mAA + AT), AA + AT neonates × TT mothers (nAA + AT × mTT), and AA + AT neonates × AA + AT mothers (nAA + AT × mAA + AT). Non-significant interactions between neonatal and maternal alleles were found for any parameter tested. However, maternal alleles affected significantly glucose, insulin, HOMA-IR, and homocysteine while neonatal alleles the arylesterase activity. Most significant differences were found between nATT + AA × mTT and nATT + AA × mAA + AT. Glycemia, insulinemia, and HOMA-IR were lower, while the Mediterranean diet adherence (MDA) was higher in the mAA + AT vs. mTT whose children were AA + AT. This dietary fact seems to counterbalance the potential negative effect on glucose homeostasis of the obesogenic A allele in neonates.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Gesteiro E,Sánchez-Muniz FJ,Ortega-Azorín C,Guillén M,Corella D,Bastida Sdoi
10.1007/s13105-016-0467-7subject
Has Abstractpub_date
2016-06-01 00:00:00pages
169-81issue
2eissn
1138-7548issn
1877-8755pii
10.1007/s13105-016-0467-7journal_volume
72pub_type
杂志文章abstract::S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimul...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-015-0418-8
更新日期:2015-09-01 00:00:00
abstract::Our previous findings demonstrated that hypothermia enhances the reduction potential in the liver and helps to maintain the plasmatic antioxidant pool. Here, we aimed to elucidate if hypothermia protects against hypoxia-induced oxidative stress damage in rat liver. Several hepatic markers of oxidative stress were comp...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0500-x
更新日期:2016-12-01 00:00:00
abstract::This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradio...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0008-8
更新日期:2010-03-01 00:00:00
abstract::The protective effects of downregulated miR-199a-5p on ischemic and hypoxic cardiomyocytes were well recognized, but the underlying mechanism of inhibited miR-199a-5p is not yet clear. The present study explored the relationship between enhanced signal transducer and activator of transcription 3 (STAT3) signaling and ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-018-0657-6
更新日期:2019-02-01 00:00:00
abstract::Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0497-1
更新日期:2016-12-01 00:00:00
abstract::In order to obtain healthier goat milk as far as its fat composition is concerned, milk production and composition trials were carried out with Granadina goats kept in semi-extensive breeding conditions. The animals were feeding indoors with a concentrate supplemented or not with 7% of fat conveniently protected again...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179791
更新日期:2000-09-01 00:00:00
abstract::Differentiation of adipocytes and their aggregation to adipose tissue are critical for mammalian growth and development. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that play important roles in adipogenesis and lipid metabolism. miR-128-3p may contribute to adipose tissue development according t...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-018-0625-1
更新日期:2018-08-01 00:00:00
abstract::The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-019-00673-9
更新日期:2019-08-01 00:00:00
abstract::The effect of long-lasting in vivo restriction of nitric oxide (NO) bioavailability on cardiac and renal P-type ATPases critical for intracellular ion homeostasis is controversial. Previous work has shown in eNOS knockout (eNOS(-/-)) mice hearts that Na(+)/K(+)- and Ca(2+)-ATPase activities were depressed but the unde...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0203-x
更新日期:2013-06-01 00:00:00
abstract::Due to its noninvasive, convenient, and practical nature, salivary testosterone (sal-T) and cortisol (sal-C) are frequently used in a clinical and applied setting. However, few studies report biological and analytical error and even fewer report the 'critical difference' which is the change required before a true biol...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13105-014-0368-6
更新日期:2014-12-01 00:00:00
abstract::Variations in the concentration of free amino acids in the muscle and plasma of trout submitted to 5 minutes of intense exercise have been studied. The responses of untrained fish and those trained performing the same type of exercise twice daily for 28 days are compared. Total amino acid concentrations in muscle tend...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::O-Acetylserine(thiol)lyase (OASTL) enzyme catalyzes the cysteine biosynthesis in photosynthetic organisms. In mature Arabidopsis thaliana the highest activity level is observed in non-photosynthetic tissues like roots, that also show significant amount of protein detected by Western blot analysis. By means of specific...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::Although pigs are adapted to starch-rich diets and have high turnover rates of glucose, very scarce information is available on the molecular basis of glucose transport. Therefore, the present study attempted a systematic screening for the presence of mRNA of glucose transport proteins in main organs of glucose absorp...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03180578
更新日期:2009-09-01 00:00:00
abstract::Decline in oxygen availability experienced under hypobaric hypoxia (HH) mediates imbalance in lung fluid clearance and is a causative agent of acute lung injury. Here, we investigate the pathological events behind acute HH mediated lung injury and assess the therapeutic efficacy of nanocurcumin in its amelioration. We...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0515-3
更新日期:2016-12-01 00:00:00
abstract::The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-016-0540-2
更新日期:2017-05-01 00:00:00
abstract::The present review aims to illustrate current knowledge about the efficacy of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) in treating/preventing several metabolic pathologies. We reviewed systematically the published evidence on the effectiveness of n-3 LC-PUFAs fish consumption or n-3 LC-PUFAs suppl...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-013-0265-4
更新日期:2013-09-01 00:00:00
abstract::Currently, there are no reports in the literature demonstrating any animal model that ingests one of the fattiest animal food source, the bovine brain. We hypothesized that a high-fat diet (HFD), based on dried bovine brain, could be used to develop an animal model possessing a spectrum of insulin resistance-related f...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0085-3
更新日期:2011-09-01 00:00:00
abstract::The number of patients that suffer some type of spinal cord lesion in recent years are high and have increased because of factors such as traffic accidents. Although their life expectancy has increased, cardiovascular illnesses is one of the main causes of morbidity and mortality. Since the degree of physical fitness ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179863
更新日期:2003-03-01 00:00:00
abstract::Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0087-1
更新日期:2011-09-01 00:00:00
abstract::In spite of a wide range of drugs being available in the market, treatment of arterial hypertension still remains a challenge, and new therapeutic strategies could be developed in order to improve the rate of success in controlling this disease. Since oxidative stress has gained importance in the last few years as one...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0017-7
更新日期:2010-06-01 00:00:00
abstract::Cells are armed with a vast repertoire of antioxidant defence mechanisms to prevent the accumulation of oxidative damage. The cellular adaptive response is an important antioxidant mechanism against physiological and pathophysiological oxidative alterations in a cell's microenvironment. The aim of this paper was to st...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165787
更新日期:2007-09-01 00:00:00
abstract::Pouteria campechiana (Kunth) Baehni. is used as a remedy for coronary trouble, liver disorders, epilepsy, skin disease, and ulcer. Therefore, the present study aims to investigate the antioxidant and hepatoprotective effect of polyphenolic-rich P. campechiana fruit extract against acetaminophen-intoxicated rats. Total...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-013-0274-3
更新日期:2014-03-01 00:00:00
abstract::Two groups of rats were fed on diets with protein from a marine specie holothuria (Holothuria forskali) or casein (for the control group) during 16 days with the aim of assessing the nutritional value of the holothuria protein. Several serum lipid levels were also determined. The results of the nutritive parameters in...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179775
更新日期:2000-03-01 00:00:00
abstract::Oxidative stress has been shown to induce apoptosis in cancer cells. Therefore, one might suspect that antioxidants may inhibit reactive oxygen species (ROS) and prevent apoptosis of cancer cells. No study has been carried out so far to elucidate the effects of N-acetylcysteine (NAC) on bleomycin-induced apoptosis in ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0173-z
更新日期:2012-12-01 00:00:00
abstract::Recently resveratrol, a compound naturally occurring in various plants, has been proposed as a potential anti-obesity compound. The aim of the present work was to analyse the effects of different doses of resveratrol on body fat and serum parameters in rats. Thirty-two male Sprague-Dawley rats were randomly divided in...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03185932
更新日期:2009-12-01 00:00:00
abstract::Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satell...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-021-00787-z
更新日期:2021-01-26 00:00:00
abstract::Conjugated linoleic acid (CLA) refers to a mixture of naturally occurring positional and geometric isomers of linoleic acid that exist in dairy products and meat. The aim of the present work was to study the effects of c-9,t-11 and t-10,c-12 CLA isomers on body fat accumulation and serum lipids in hamsters fed an athe...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179915
更新日期:2003-09-01 00:00:00
abstract::Opioid receptors play an important role in modulation of hyperalgesia in inflamed tissues, but chronic morphine application induces such side effects as tolerance. There is near communications between cytokines and mu opioid receptor expression. This study was aimed to assess the role of serum IL-10 in morphine tolera...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-014-0330-7
更新日期:2014-06-01 00:00:00
abstract::High fat diet (HFD) is a common cause of metabolic syndrome and type 2 diabetes mellitus. Published data showed that HFD and subsequent dyslipidemia are major triggers for oxidative stress. Forty-eight male Sprague-Dawley rats, weighing 170-200 g, were divided into six groups: control, control with vitamin E (100 mg/k...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-013-0250-y
更新日期:2013-12-01 00:00:00
abstract::Gut bacteria play an important role in several metabolic processes and human diseases, such as obesity and accompanying co-morbidities, such as fatty liver disease, insulin resistance/diabetes, and cardiovascular events. Among other factors, dietary patterns, probiotics, prebiotics, synbiotics, antibiotics, and non-di...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-017-0564-2
更新日期:2018-02-01 00:00:00