abstract：:Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satell...

journal_title：Journal of physiology and biochemistry

authors： Setiawan I,Sanjaya A,Lesmana R,Yen PM,Goenawan H

更新日期：2021-01-26 00:00:00

abstract：:Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathin...

journal_title：Journal of physiology and biochemistry

authors： López-González MV,González-García M,Peinado-Aragonés CA,Barbancho MÁ,Díaz-Casares A,Dawid-Milner MS

更新日期：2020-11-01 00:00:00

abstract：:Homocysteine (Hcy) is considered an independent risk factor for various cardiovascular diseases including atherosclerosis which is associated with lipid metabolism, inflammation, and oxidative stress. Results from our previous study suggested that Hcy-induced atherosclerosis could be reversed by Herpud1 knockout which...

journal_title：Journal of physiology and biochemistry

authors： Gao F,Zhang J,Ni T,Lin N,Lin H,Luo H,Guo H,Chi J

更新日期：2020-08-01 00:00:00

abstract：:Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction ...

journal_title：Journal of physiology and biochemistry

authors： Rodríguez A,Catalán V,Ramírez B,Unamuno X,Portincasa P,Gómez-Ambrosi J,Frühbeck G,Becerril S

更新日期：2020-05-01 00:00:00

abstract：:Low shear stress (LSS) occurs in areas where atherosclerosis is prevalent. Many studies have revealed that signal transducer and activator of transcription 1 (STAT1) plays a significant role in cardiovascular disease. Nonetheless, the mechanism underlying the connection between STAT1 and LSS is not fully understood. T...

journal_title：Journal of physiology and biochemistry

authors： Zhu L,Wang F,Yang H,Zhang J,Chen S

更新日期：2020-02-01 00:00:00

abstract：:Previous studies have shown that stromal interaction molecule1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) contributes to intracellular Ca2+ accumulation in H9C2 cells subjected to hypoxia/reoxygenation(H/R) injury. The aim of the present study was to investigate the effect of resveratrol on STIM1-mediated intra...

journal_title：Journal of physiology and biochemistry

authors： Xu H,Cheng J,Wang X,Liu H,Wang S,Wu J,Xu B,Chen A,He F

更新日期：2019-11-01 00:00:00

abstract：:The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...

journal_title：Journal of physiology and biochemistry

authors： Villanueva-Millán MJ,Pérez-Matute P,Recio-Fernández E,Lezana Rosales JM,Oteo JA

更新日期：2019-08-01 00:00:00

abstract：:Adipose tissue has long been considered to be involved in tumor progression. However, the adipocyte-secreted molecular determinants that regulate hepatocellular cancer progression have not been defined yet. In this study, the expression pattern of exosome miRNAs in hepatocellular carcinoma (HCC) patients with high bod...

journal_title：Journal of physiology and biochemistry

authors： Liu Y,Tan J,Ou S,Chen J,Chen L

更新日期：2019-08-01 00:00:00

abstract：:High plasma lactate levels have been associated with reduced mitochondrial respiratory capacity and increased type 2 diabetes risk, while mitochondrial DNA (mtDNA) copy number has been proposed as a biomarker of mitochondrial function linked to glucose homeostasis. The aim of this study was to evaluate the association...

journal_title：Journal of physiology and biochemistry

authors： Santos JL,Cataldo LR,Cortés-Rivera C,Bravo C,Díaz-Casanova L,Martínez JA,Milagro FI,Galgani J

更新日期：2019-08-01 00:00:00

abstract：:Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA-induced protection against ischemia-reperfusion-induced myocardia...

journal_title：Journal of physiology and biochemistry

authors： Demaison L,Leger T,Vergely C,Rochette L,Azarnoush K

更新日期：2019-08-01 00:00:00

abstract：:The protective effects of downregulated miR-199a-5p on ischemic and hypoxic cardiomyocytes were well recognized, but the underlying mechanism of inhibited miR-199a-5p is not yet clear. The present study explored the relationship between enhanced signal transducer and activator of transcription 3 (STAT3) signaling and ...

journal_title：Journal of physiology and biochemistry

authors： Zhou Y,Pang B,Xiao Y,Zhou S,He B,Zhang F,Liu W,Peng H,Li P

更新日期：2019-02-01 00:00:00

abstract：:A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxida...

journal_title：Journal of physiology and biochemistry

authors： Thirupathi A,Pinho RA

更新日期：2018-08-01 00:00:00

abstract：:Differentiation of adipocytes and their aggregation to adipose tissue are critical for mammalian growth and development. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that play important roles in adipogenesis and lipid metabolism. miR-128-3p may contribute to adipose tissue development according t...

journal_title：Journal of physiology and biochemistry

authors： Chen C,Deng Y,Hu X,Ren H,Zhu J,Fu S,Xie J,Peng Y

更新日期：2018-08-01 00:00:00

abstract：:Gut bacteria play an important role in several metabolic processes and human diseases, such as obesity and accompanying co-morbidities, such as fatty liver disease, insulin resistance/diabetes, and cardiovascular events. Among other factors, dietary patterns, probiotics, prebiotics, synbiotics, antibiotics, and non-di...

journal_title：Journal of physiology and biochemistry

authors： Roca-Saavedra P,Mendez-Vilabrille V,Miranda JM,Nebot C,Cardelle-Cobas A,Franco CM,Cepeda A

更新日期：2018-02-01 00:00:00

abstract：:Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription fa...

journal_title：Journal of physiology and biochemistry

authors： Thirupathi A,de Souza CT

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and ...

journal_title：Journal of physiology and biochemistry

authors： Grzelak T,Dutkiewicz A,Paszynska E,Dmitrzak-Weglarz M,Slopien A,Tyszkiewicz-Nwafor M

更新日期：2017-05-01 00:00:00

abstract：:We and others have demonstrated a protective role for pacing postconditioning (PPC) against ischemia/reperfusion (I/R) injury in the heart; however, the underlying mechanisms behind these protective effects are not completely understood. In this study, we wanted to further characterize PPC-mediated cardiac protection,...

journal_title：Journal of physiology and biochemistry

authors： Babiker FA,Al-Jarallah A,Joseph S

更新日期：2017-05-01 00:00:00

abstract：:Paeonol (Pae) is the main active ingredient from the root bark of Paeonia moutan and the grass of Radix Cynanchi Paniculati. Numerous reports indicate that Pae effectively inhibits several types of cancer lines. In this study, we report that Pae hinders prostate cancer growth both in vivo and in vitro. Human prostate ...

journal_title：Journal of physiology and biochemistry

authors： Xu Y,Zhu JY,Lei ZM,Wan LJ,Zhu XW,Ye F,Tong YY

更新日期：2017-05-01 00:00:00

abstract：:Obesity is a leading health problem facing the modern world; however, no effective therapy for this health issue has yet been developed. A promising research direction to identify novel therapies to prevent obesity has emerged from discoveries on development and function of brown/brite adipocytes in mammals. Important...

journal_title：Journal of physiology and biochemistry

authors： Chu DT,Tao Y

更新日期：2017-02-01 00:00:00

abstract：:Human diploid fibroblasts (HDFs) proliferation in culture has been used as a model of aging at the cellular level. Growth arrest is one of the most important mechanisms responsible for replicative senescence. Recent researches have been focusing on the function of vitamin E in modulating cellular signaling and gene ex...

journal_title：Journal of physiology and biochemistry

authors： Zainuddin A,Chua KH,Tan JK,Jaafar F,Makpol S

更新日期：2017-02-01 00:00:00

abstract：:Iron is a trace element and a structural part of antioxidant enzymes, and its requirements vary according to age and gender. We hypothesized that iron deficiency (ID) leads to an increase in free radicals which mainly affect the brain, and the severity of damage would therefore be dependent on age and gender. Two grou...

journal_title：Journal of physiology and biochemistry

authors： Vieyra-Reyes P,Millán-Aldaco D,Palomero-Rivero M,Jiménez-Garcés C,Hernández-González M,Caballero-Villarraso J

更新日期：2017-02-01 00:00:00

abstract：:Our previous findings demonstrated that hypothermia enhances the reduction potential in the liver and helps to maintain the plasmatic antioxidant pool. Here, we aimed to elucidate if hypothermia protects against hypoxia-induced oxidative stress damage in rat liver. Several hepatic markers of oxidative stress were comp...

journal_title：Journal of physiology and biochemistry

authors： Garnacho-Castaño MV,Alva N,Sánchez-Nuño S,Bardallo RG,Palomeque J,Carbonell T

更新日期：2016-12-01 00:00:00

abstract：:Increased incidence of chronic kidney disease (CKD) with consecutive progression to end-stage renal disease represents a significant burden to healthcare systems. Renal tubulointerstitial fibrosis (TIF) is a classical hallmark of CKD and is well correlated with the loss of renal function. The bioactive lysophospholipi...

journal_title：Journal of physiology and biochemistry

authors： Mirzoyan K,Baïotto A,Dupuy A,Marsal D,Denis C,Vinel C,Sicard P,Bertrand-Michel J,Bascands JL,Schanstra JP,Klein J,Saulnier-Blache JS

更新日期：2016-12-01 00:00:00

abstract：:Decline in oxygen availability experienced under hypobaric hypoxia (HH) mediates imbalance in lung fluid clearance and is a causative agent of acute lung injury. Here, we investigate the pathological events behind acute HH mediated lung injury and assess the therapeutic efficacy of nanocurcumin in its amelioration. We...

journal_title：Journal of physiology and biochemistry

authors： Nehra S,Bhardwaj V,Bansal A,Saraswat D

更新日期：2016-12-01 00:00:00

abstract：:Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...

journal_title：Journal of physiology and biochemistry

authors： Afzal S,Sattar MA,Johns EJ,Abdulla MH,Akhtar S,Hashmi F,Abdullah NA

更新日期：2016-12-01 00:00:00

abstract：:Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help ...

journal_title：Journal of physiology and biochemistry

authors： San-Cristobal R,Navas-Carretero S,Milagro FI,Riezu-Boj JI,Guruceaga E,Celis-Morales C,Livingstone KM,Brennan L,Lovegrove JA,Daniel H,Saris WH,Traczyk I,Manios Y,Gibney ER,Gibney MJ,Mathers JC,Martinez JA

更新日期：2016-08-01 00:00:00

abstract：:The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements...

journal_title：Journal of physiology and biochemistry

authors： Gesteiro E,Sánchez-Muniz FJ,Ortega-Azorín C,Guillén M,Corella D,Bastida S

更新日期：2016-06-01 00:00:00

abstract：:The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations in endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated with obesity. The aim of this study was to investigate ER imbalance in the pancreas of a mic...

journal_title：Journal of physiology and biochemistry

authors： Soeda J,Mouralidarane A,Cordero P,Li J,Nguyen V,Carter R,Kapur SR,Pombo J,Poston L,Taylor PD,Vinciguerra M,Oben JA

更新日期：2016-06-01 00:00:00

abstract：:Cholesterolemia is associated with pro-oxidative and proinflammatory effects. Glucomannan- or glucomannan plus spirulina-enriched surimis were included in cholesterol-enriched high-saturated diets to test the effects on lipemia; antioxidant status (glutathione status, and antioxidant enzymatic levels, expressions and ...

journal_title：Journal of physiology and biochemistry

authors： Vázquez-Velasco M,González-Torres L,López-Gasco P,Bastida S,Benedí J,González-Muñoz MJ,Sánchez-Muniz FJ

更新日期：2015-12-01 00:00:00

abstract：:In the present study, we investigated the efficiency of rosmarinic acid (RA) in preventing the alteration of oxidative parameters in the liver and kidney of diabetic rats induced by streptozotocin (STZ). The animals were divided into six groups (n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol, and di...

journal_title：Journal of physiology and biochemistry

authors： Mushtaq N,Schmatz R,Ahmed M,Pereira LB,da Costa P,Reichert KP,Dalenogare D,Pelinson LP,Vieira JM,Stefanello N,de Oliveira LS,Mulinacci N,Bellumori M,Morsch VM,Schetinger MR

更新日期：2015-12-01 00:00:00

abstract：:In traditional herbal medicine, Rock Tea (Jasonia glutinosa) is known for its prophylactic and therapeutic value in various disorders including arterial hypertension. However, the mechanism by which Rock Tea exerts blood pressure-lowering actions has not been elucidated yet. Our aim was to demonstrate vasorelaxing eff...

journal_title：Journal of physiology and biochemistry

authors： Valero MS,Oliván-Viguera A,Garrido I,Langa E,Berzosa C,López V,Gómez-Rincón C,Murillo MD,Köhler R

更新日期：2015-12-01 00:00:00

abstract：:Glitazones are peroxisome proliferator-activated receptor gamma (PPARγ) agonists widely used as antidiabetic drugs also known as thiazolidinediones. Most of them exert other effects such as anti-inflammatory actions via mechanisms supposed to be independent from PPARγ activation (e.g., decreased plasma monocyte chemoa...

journal_title：Journal of physiology and biochemistry

authors： Carpéné C,Bizou M,Tréguer K,Hasnaoui M,Grès S

更新日期：2015-09-01 00:00:00

abstract：:S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimul...

journal_title：Journal of physiology and biochemistry

authors： Rodríguez M,Moltó E,Aguado L,Gallardo N,Andrés A,Arribas C

更新日期：2015-09-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective effect of Tunisian flaxseed oil (Linum usitatissimum) against isoproterenol-induced myocardial infarction in rats by studying hypertensive and cardiac damage markers especially electrocardiographic changes and troponin T serum level. In vitro, the extract...

journal_title：Journal of physiology and biochemistry

authors： Derbali A,Mnafgui K,Affes M,Derbali F,Hajji R,Gharsallah N,Allouche N,El Feki A

更新日期：2015-06-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a complicated systemic disease, and the exact pathogenetic molecular mechanism is unclear. Distinct histone modifications regulate gene expression in certain diseases, but little is known about histone epigenetics in diabetes. In the current study, C57BL/6 J mice were used to build T2D model, ...

journal_title：Journal of physiology and biochemistry

authors： Tu P,Li X,Ma B,Duan H,Zhang Y,Wu R,Ni Z,Jiang P,Wang H,Li M,Zhu J,Li M

更新日期：2015-03-01 00:00:00

abstract：:Cancer stem cells (CSCs), or cancer cells with stem cell properties, are a rare population of tumor bulk and are recognized to be responsible for cancer recurrence, drug resistance, and metastasis. However, the molecular mechanisms of how to regulate the differentiation and self-renewing of CSCs are poorly understood....

journal_title：Journal of physiology and biochemistry

authors： Zhang Y,Hao J,Zheng Y,Jing D,Shen Y,Wang J,Zhao Z

更新日期：2015-03-01 00:00:00

abstract：:Due to its noninvasive, convenient, and practical nature, salivary testosterone (sal-T) and cortisol (sal-C) are frequently used in a clinical and applied setting. However, few studies report biological and analytical error and even fewer report the 'critical difference' which is the change required before a true biol...

journal_title：Journal of physiology and biochemistry

authors： Hayes LD,Sculthorpe N,Young JD,Baker JS,Grace FM

更新日期：2014-12-01 00:00:00

abstract：:Diabetes is a risk factor for cardiovascular disease that has a multifactorial etiology, with oxidative stress as an important component. Our previous observation of a significant diabetes-related increase in rat cardiac catalase (CAT) activity suggested that CAT could play a major role in delaying the development of ...

journal_title：Journal of physiology and biochemistry

authors： Ivanović-Matić S,Bogojević D,Martinović V,Petrović A,Jovanović-Stojanov S,Poznanović G,Grigorov I

更新日期：2014-12-01 00:00:00

abstract：:While the unequivocal pattern of endothelial nitric oxide synthase (eNOS) inhibition in cardiovascular control is recognized, the role of NO produced by neuronal NOS (nNOS) remains unclear. The aim of this study was to compare the effects of chronic treatment with 7-nitroindazole (7-NI, nNOS inhibitor) and N(G)-nitro-...

journal_title：Journal of physiology and biochemistry

authors： Cacanyiova S,Berenyiova A,Malekova M,Kristek F,Dovinova I,Krenek P,Pivackova L,Pifkova I

更新日期：2014-09-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that a single bout of moderate exercise stimulates macrophage function, increasing phagocytic capacity, and production of hydrogen peroxide and nitric oxide (NO˙) through nuclear factor kappa B activation. In this work, we investigated the role of α- and β-adrenor...

journal_title：Journal of physiology and biochemistry

authors： da Silva Rossato J,Krause M,Fernandes AJ,Fernandes JR,Seibt IL,Rech A,Homem de Bittencourt PI Jr

更新日期：2014-06-01 00:00:00