Abstract：
:S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimulated. Here we present evidences demonstrating for the first time that s-resistin, like resistin, blocks insulin signalling pathway by inhibiting insulin receptor, insulin receptor substrate 1, protein kinase B/Akt and the mammalian target of rapamycin phosphorylation, and increasing the suppressor of cytokine signalling 3 levels being the later probably due to augmented of leptin expression. Thus, our data suggest that s-resistin could act by a still unknown intracrine pathway as an intracellular sensor, regulating the adipocyte insulin sensitivity.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Rodríguez M,Moltó E,Aguado L,Gallardo N,Andrés A,Arribas Cdoi
10.1007/s13105-015-0418-8subject
Has Abstractpub_date
2015-09-01 00:00:00pages
381-90issue
3eissn
1138-7548issn
1877-8755journal_volume
71pub_type
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