Abstract：
:Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction and obesity, but also in fat browning, a process that induces a phenotypic switch from energy-storing white adipocytes to thermogenic brown fat-like cells. The fat browning process and, consequently, thermogenesis can also be stimulated by physical exercise. Contracting skeletal muscle is a metabolically active tissue that participates in several endocrine functions through the production of bioactive factors, collectively termed myokines, proposed as the mediators of physical activity-induced health benefits. Myokines affect muscle mass, have profound effects on glucose and lipid metabolism, and promote browning and thermogenesis of white AT in an endocrine and/or paracrine manner. The present review focuses on the role of different myokines and adipokines in the regulation of fat browning, as well as in the potential cross-talk between AT and skeletal muscle, in order to control body weight, energy expenditure and thermogenesis.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Rodríguez A,Catalán V,Ramírez B,Unamuno X,Portincasa P,Gómez-Ambrosi J,Frühbeck G,Becerril Sdoi
10.1007/s13105-020-00736-2subject
Has Abstractpub_date
2020-05-01 00:00:00pages
227-240issue
2eissn
1138-7548issn
1877-8755pii
10.1007/s13105-020-00736-2journal_volume
76pub_type
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