Abstract：
:Type 2 diabetes (T2D) is a complicated systemic disease, and the exact pathogenetic molecular mechanism is unclear. Distinct histone modifications regulate gene expression in certain diseases, but little is known about histone epigenetics in diabetes. In the current study, C57BL/6 J mice were used to build T2D model, then treated with exendin-4 (10 μg/kg). Histone H3K9 and H3K23 acetylation, H3K4 monomethylation and H3K9 dimethylation were explored by Western blotting of liver histone extracts. Real-time polymerase chain reaction (PCR) was used to examine expression levels of diabetes-related genes, while chromatin immunoprecipitation (ChIP) was applied to analyze H3 and H3K9 acetylation, H3K4 monomethylation, and H3K9 dimethylation in the promoter of facilitated glucose transporter member 2 (Glut2) gene. The results showed that liver's total H3K4 monomethylation and H3K9 dimethylation was increased in diabetic mice, which was abrogated with the treatment of exendin-4. In contrast, H3K9 and H3K23 acetylation were reduced in diabetic mice, while exendin-4 only alleviated the reduction of H3K9 acetylation. Our data indicated that the progression of type 2 diabetes mellitus (T2D) is associated with global liver histone H3K9 and H3K23 acetylation, H3K4 monomethylation, and H3K9 dimethylation. Exploiting exact histone modify enzyme inhibitors, which may represent a novel strategy to prevent T2D.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Tu P,Li X,Ma B,Duan H,Zhang Y,Wu R,Ni Z,Jiang P,Wang H,Li M,Zhu J,Li Mdoi
10.1007/s13105-015-0385-0subject
Has Abstractpub_date
2015-03-01 00:00:00pages
89-98issue
1eissn
1138-7548issn
1877-8755journal_volume
71pub_type
杂志文章abstract：:GLUT2 is a facilitative glucose transporter located in the plasma membrane of the liver, pancreatic, intestinal, kidney cells as well as in the portal and the hypothalamus areas. Due to its low affinity and high capacity, GLUT2 transports dietary sugars, glucose, fructose and galactose in a large range of physiologica...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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abstract：:The protective effects of downregulated miR-199a-5p on ischemic and hypoxic cardiomyocytes were well recognized, but the underlying mechanism of inhibited miR-199a-5p is not yet clear. The present study explored the relationship between enhanced signal transducer and activator of transcription 3 (STAT3) signaling and ...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2004-09-01 00:00:00
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更新日期：2000-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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更新日期：2014-06-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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更新日期：1998-09-01 00:00:00
abstract：:Increased incidence of chronic kidney disease (CKD) with consecutive progression to end-stage renal disease represents a significant burden to healthcare systems. Renal tubulointerstitial fibrosis (TIF) is a classical hallmark of CKD and is well correlated with the loss of renal function. The bioactive lysophospholipi...
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of physiology and biochemistry
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更新日期：2015-09-01 00:00:00
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更新日期：2014-03-01 00:00:00
abstract：:In traditional herbal medicine, Rock Tea (Jasonia glutinosa) is known for its prophylactic and therapeutic value in various disorders including arterial hypertension. However, the mechanism by which Rock Tea exerts blood pressure-lowering actions has not been elucidated yet. Our aim was to demonstrate vasorelaxing eff...
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
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