Abstract：
:In the present study, we investigated the efficiency of rosmarinic acid (RA) in preventing the alteration of oxidative parameters in the liver and kidney of diabetic rats induced by streptozotocin (STZ). The animals were divided into six groups (n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol, and diabetic/RA 10 mg/kg. After 3 weeks of treatment, we found that TBARS levels in liver and kidney were significantly increased in the diabetic/saline group and the administration of RA prevented this increase in the liver and kidney (P < 0.05). Diabetes caused a significant decrease in the activity of superoxide dismutase (SOD) and catalase (CAT) in the diabetes/saline group (P < 0.05). However, the treatment with 10 mg/kg RA (antioxidant) prevented this alteration in SOD and CAT activity in the diabetic RA group (P < 0.05). In addition, RA reverses the decrease in ascorbic acid and non-protein-thiol (NPSH) levels in diabetic rats. The treatment with RA also prevented the decrease in the Delta-aminolevulinic acid dehydratase (ALA-D) activity in the liver and kidney of diabetic rats. Furthermore, RA did not have any effect on glycemic levels. These results indicate that RA effectively reduced the oxidative stress induced by STZ, suggesting that RA is a potential candidate for the prevention and treatment of pathological conditions in diabetic models.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Mushtaq N,Schmatz R,Ahmed M,Pereira LB,da Costa P,Reichert KP,Dalenogare D,Pelinson LP,Vieira JM,Stefanello N,de Oliveira LS,Mulinacci N,Bellumori M,Morsch VM,Schetinger MRdoi
10.1007/s13105-015-0438-4subject
Has Abstractpub_date
2015-12-01 00:00:00pages
743-51issue
4eissn
1138-7548issn
1877-8755pii
10.1007/s13105-015-0438-4journal_volume
71pub_type
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