Abstract：
:Reduced nitric oxide availability and a heterogeneous pattern of nitric oxide synthase activity in some tissues have been reported in hypothyroidism. This study aimed at determining the effects of oral nitrate and L-arginine administration on serum, heart, and aorta nitric oxide metabolite concentrations in fetal hypothyroid rats. In an experimental study, pregnant Wistar rats were administrated tap water or 0.02 % of 6-propyl-2-thiouracil in drinking water during pregnancy and their male pups were followed (n = 8/group). In adult progeny, serum, heart, and aorta nitric oxide metabolite concentrations were measured by the Griess method after 1-week administration of sodium nitrate (500 mg/L) or L-arginine (2 %) in drinking water. Serum thyroid hormone and thyroid-stimulating hormone levels were also measured. Compared to controls, fetal hypothyroid progeny had significantly lower nitric oxide metabolite concentrations in heart (0.32 ± 0.07 vs. 0.90 ± 0.14 nmol/mg protein, p = 0.004) and aorta (2.98±0.56 vs. 6.15±0.74 nmol/mg protein, p = 0.011) tissues. Nitrate therapy restored heart nitric oxide metabolite levels decreased by fetal hypothyroidism, while L-arginine administration further decreased aorta nitric oxide metabolite levels. Sodium nitrate increased and L-arginine decreased serum nitric oxide metabolite levels in both control and fetal hypothyroid animals. In conclusion, nitrate therapy restores decreased heart nitric oxide metabolite levels, whereas L-arginine decreases aorta nitric oxide metabolite levels even further in fetal hypothyroid rats, findings relevant to the cardiovascular consequences of congenital hypothyroidism in adulthood.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Ghasemi A,Mehrazin F,Zahediasl Sdoi
10.1007/s13105-013-0251-xsubject
Has Abstractpub_date
2013-12-01 00:00:00pages
751-9issue
4eissn
1138-7548issn
1877-8755journal_volume
69pub_type
杂志文章abstract：:In order to evaluate the expression of nuclear receptors at the peripheral level in obese subjects, messenger RNA (mRNA) levels of different isoforms of retinoic acid receptor (RAR), triiodothyronine (TR), and peroxisome proliferator-activated receptor (PPAR) were determined and compared in peripheral mononuclear bloo...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-010-0006-x
更新日期：2010-03-01 00:00:00
abstract：:The purpose of this study was to apply the new approach for Metabolic Individual Risk-factor And Clustering Estimation (MIRACLE) score in a group of Spanish obese children and adolescents and to describe its relationship with other metabolic risk factors. 153 children with simple obesity were studied: 79 males and 74 ...
journal_title：Journal of physiology and biochemistry
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:The present review aims to illustrate current knowledge about the efficacy of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) in treating/preventing several metabolic pathologies. We reviewed systematically the published evidence on the effectiveness of n-3 LC-PUFAs fish consumption or n-3 LC-PUFAs suppl...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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doi：10.1007/s13105-014-0330-7
更新日期：2014-06-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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doi：10.1007/s13105-016-0497-1
更新日期：2016-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179853
更新日期：2002-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-013-0269-0
更新日期：2013-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-016-0536-y
更新日期：2017-02-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-011-0081-7
更新日期：2011-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2006-06-01 00:00:00
abstract：:Previous studies have shown that stromal interaction molecule1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) contributes to intracellular Ca2+ accumulation in H9C2 cells subjected to hypoxia/reoxygenation(H/R) injury. The aim of the present study was to investigate the effect of resveratrol on STIM1-mediated intra...
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-06-01 00:00:00
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更新日期：2017-05-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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更新日期：2000-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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更新日期：2003-03-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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更新日期：2019-08-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：1999-12-01 00:00:00
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更新日期：2014-06-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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更新日期：2010-03-01 00:00:00
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更新日期：2020-02-01 00:00:00
abstract：:Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for the first time in the maternal-fetal interface. In cancer context, where high number of natural killer (NK) cells is described, the presence of HLA-G in its soluble form is thought to be essential for NK cells signaling. To evaluate intrace...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
