Abstract：
:Obesity is a leading health problem facing the modern world; however, no effective therapy for this health issue has yet been developed. A promising research direction to identify novel therapies to prevent obesity has emerged from discoveries on development and function of brown/brite adipocytes in mammals. Importantly, there is evidence for the presence and function of active thermogenic brown adipocytes in both infants and adult humans. Several new investigations have shown that thermogenic adipocytes are beneficial to maintain glucose homeostasis, insulin sensitivity, and a healthy body fat content. Such thermogenic adipocytes have been considered as targets to develop a therapy for preventing obesity. This short review seeks to highlight recent findings on the development and function of brown/brite adipocytes in humans and to discuss potential treatments based on these adipocytes to reduce obesity and its related disorders.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Chu DT,Tao Ydoi
10.1007/s13105-016-0536-ysubject
Has Abstractpub_date
2017-02-01 00:00:00pages
1-4issue
1eissn
1138-7548issn
1877-8755pii
10.1007/s13105-016-0536-yjournal_volume
73pub_type
杂志文章,评审abstract：:To investigate the effects of pectin on cholesterol metabolism, normal rats were fed for three weeks a diet containing 2.5 or 5 % apple or orange pectin, or without pectin (control). Cholesterol concentrations were determined in faeces after 1, 2 and 3 weeks of treatment, and in liver and serum at the end of the exper...
journal_title：Journal of physiology and biochemistry
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abstract：:The effect of long-lasting in vivo restriction of nitric oxide (NO) bioavailability on cardiac and renal P-type ATPases critical for intracellular ion homeostasis is controversial. Previous work has shown in eNOS knockout (eNOS(-/-)) mice hearts that Na(+)/K(+)- and Ca(2+)-ATPase activities were depressed but the unde...
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journal_title：Journal of physiology and biochemistry
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doi：10.1007/s13105-013-0274-3
更新日期：2014-03-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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doi：
更新日期：1999-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0500-x
更新日期：2016-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
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abstract：:The question as to whether A3 adenosine receptor (A3AR) agonists, N (6)-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N (6)-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations with or without the involvement of A3AR has been a controv...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-012-0222-7
更新日期：2013-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0467-7
更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-020-00729-1
更新日期：2020-02-01 00:00:00
abstract：:Increased incidence of chronic kidney disease (CKD) with consecutive progression to end-stage renal disease represents a significant burden to healthcare systems. Renal tubulointerstitial fibrosis (TIF) is a classical hallmark of CKD and is well correlated with the loss of renal function. The bioactive lysophospholipi...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0518-0
更新日期：2016-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179853
更新日期：2002-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-021-00787-z
更新日期：2021-01-26 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03168227
更新日期：2007-06-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-017-0560-6
更新日期：2016-08-01 00:00:00
abstract：:MicroRNAs (miRNAs), a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The ability of one single miRNA regulating multiple functionally related mRNAs makes it a new potential candidate for cancer gene therapy. Let-7s miRNAs have been demonstrated as tumor-supp...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-011-0124-0
更新日期：2012-03-01 00:00:00
abstract：:The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-019-00673-9
更新日期：2019-08-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0535-z
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0529-x
更新日期：2017-02-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2007-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
