Abstract:
:The purpose of this study was to apply the new approach for Metabolic Individual Risk-factor And Clustering Estimation (MIRACLE) score in a group of Spanish obese children and adolescents and to describe its relationship with other metabolic risk factors. 153 children with simple obesity were studied: 79 males and 74 females, mean age 11.2 +/- 2.2. Obesity was defined when BMI was higher than the age and sex specific equivalent to 30 kg/m2 in adults. MIRACLE score included: family history (early cardiovascular disease, type 2 diabetes, and hypertension), individual history (small for gestational age and ethnic origin), clinical features (BMI, waist circumference > 90th percentile and blood pressure > 95th percentile) and metabolic abnormalities (glucose intolerance or type 2 diabetes). It was assigned a value of 1 to "presence" and 0 to" absence" in every patient. The children were considered as having metabolic risk when at least 5 items were present. Triglycerides, HDL-cholesterol, apolipoprotein B, apolipoprotein A1, glucose and HOMA index, were measured too. The most frequent clinical features of MIRACLE score were: excess waist circumference (95.4%) and hypertension (41.8%). Family history criteria were frequent (55.3% for type 2 diabetes, 39.1% for hypertension and 31.3% for early cardiovascular disease). Individual risk factors were not frequent. Glucose intolerance was detected in 22.2% of the obese patients. A MIRACLE score > or = 5 was found in 37.4% of the children studied, being associated with a significant risk of dyslipidemia (triglycerides, p = 0.040; HDL-cholesterol, p = 0.006; LDL-cholesterol p = 0.038; apolipoprotein B, p = 0.008) only in females. In conclusion, the MIRACLE score is useful in order to detect metabolic risk in obese children but it seems necessary to improve the score, by including other features of the metabolic syndrome like lipid profile or indirect indicators of insulin resistance.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Bueno G,Moreno LA,Bueno O,Morales J,Pérez-Roche T,Garagorri JM,Bueno Mdoi
10.1007/BF03165766subject
Has Abstractpub_date
2007-12-01 00:00:00pages
347-55issue
4eissn
1138-7548issn
1877-8755journal_volume
63pub_type
杂志文章abstract::In spite of a wide range of drugs being available in the market, treatment of arterial hypertension still remains a challenge, and new therapeutic strategies could be developed in order to improve the rate of success in controlling this disease. Since oxidative stress has gained importance in the last few years as one...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0017-7
更新日期:2010-06-01 00:00:00
abstract::Chronic renal disease is characterized by the accumulation of extracellular matrix proteins in the kidney and a loss of renal function. Tubulointerstitial fibrosis has been reported to play an important role in the progression of chronic renal diseases. Transforming growth factor-beta1 (TGF-beta1) is a profibrotic cyt...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03168452
更新日期:2005-09-01 00:00:00
abstract::The weight loss observed in consumers of extracts of Citrus aurantium (bitter orange) has been tentatively attributed to the lipolytic and thermogenic effects of the alkaloids abundant in the unripe fruit. Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus me...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0078-2
更新日期:2011-09-01 00:00:00
abstract::O-Acetylserine(thiol)lyase (OASTL) enzyme catalyzes the cysteine biosynthesis in photosynthetic organisms. In mature Arabidopsis thaliana the highest activity level is observed in non-photosynthetic tissues like roots, that also show significant amount of protein detected by Western blot analysis. By means of specific...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::The objective of the present study was to assess the usefulness and accuracy of different anthropometric measurements in the diagnosis of abdominal visceral obesity in overweight/obese women attending to age and menopausal status. The secondary objective was to evaluate the usefulness of waist circumference (WC) in tw...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165753
更新日期:2006-12-01 00:00:00
abstract::In traditional herbal medicine, Rock Tea (Jasonia glutinosa) is known for its prophylactic and therapeutic value in various disorders including arterial hypertension. However, the mechanism by which Rock Tea exerts blood pressure-lowering actions has not been elucidated yet. Our aim was to demonstrate vasorelaxing eff...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-015-0442-8
更新日期:2015-12-01 00:00:00
abstract::The study investigates the effect of weight-maintaining high-sucrose (HSD) and high-fat (HFD) diets on plasma glucose and insulin concentrations in lean and obese women, and verifies the correlation between insulin profile and body composition. Lean (G1 group, n=6, BMI= 21.4 (20.2-22.8) kg/m2) and overweight/obese (G2...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03168238
更新日期:2008-06-01 00:00:00
abstract::Type 2 diabetes (T2D) is a complicated systemic disease, and the exact pathogenetic molecular mechanism is unclear. Distinct histone modifications regulate gene expression in certain diseases, but little is known about histone epigenetics in diabetes. In the current study, C57BL/6 J mice were used to build T2D model, ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-015-0385-0
更新日期:2015-03-01 00:00:00
abstract::In pregnancy there occurs maternal tolerance to the foetus. Several mechanisms have been proposed to explain this phenomenon. The main immune population in the decidua are macrophages and natural killer cells, but with some "special" suppressor characteristics. There is also a predominant TH2 response. The non classic...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/BF03167033
更新日期:2004-09-01 00:00:00
abstract::Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0497-1
更新日期:2016-12-01 00:00:00
abstract::S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimul...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-015-0418-8
更新日期:2015-09-01 00:00:00
abstract::Previous studies have shown that stromal interaction molecule1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) contributes to intracellular Ca2+ accumulation in H9C2 cells subjected to hypoxia/reoxygenation(H/R) injury. The aim of the present study was to investigate the effect of resveratrol on STIM1-mediated intra...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-019-00704-5
更新日期:2019-11-01 00:00:00
abstract::MicroRNAs (miRNAs), a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The ability of one single miRNA regulating multiple functionally related mRNAs makes it a new potential candidate for cancer gene therapy. Let-7s miRNAs have been demonstrated as tumor-supp...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0124-0
更新日期:2012-03-01 00:00:00
abstract::Adipose tissue has long been considered to be involved in tumor progression. However, the adipocyte-secreted molecular determinants that regulate hepatocellular cancer progression have not been defined yet. In this study, the expression pattern of exosome miRNAs in hepatocellular carcinoma (HCC) patients with high bod...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-019-00692-6
更新日期:2019-08-01 00:00:00
abstract::Hearts from subjects with different ages have different Ca(2+) signaling. Release of Ca(2+) from intracellular stores in response to an action potential initiates cardiac contraction. Both depolarization-stimulated and spontaneous Ca(2+) releases, Ca(2+) transients and Ca(2+) sparks, demonstrate the main events of exc...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0077-3
更新日期:2011-09-01 00:00:00
abstract::Low shear stress (LSS) occurs in areas where atherosclerosis is prevalent. Many studies have revealed that signal transducer and activator of transcription 1 (STAT1) plays a significant role in cardiovascular disease. Nonetheless, the mechanism underlying the connection between STAT1 and LSS is not fully understood. T...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-020-00729-1
更新日期:2020-02-01 00:00:00
abstract::Oxidative stress has been shown to induce apoptosis in cancer cells. Therefore, one might suspect that antioxidants may inhibit reactive oxygen species (ROS) and prevent apoptosis of cancer cells. No study has been carried out so far to elucidate the effects of N-acetylcysteine (NAC) on bleomycin-induced apoptosis in ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0173-z
更新日期:2012-12-01 00:00:00
abstract::Human diploid fibroblasts (HDFs) proliferation in culture has been used as a model of aging at the cellular level. Growth arrest is one of the most important mechanisms responsible for replicative senescence. Recent researches have been focusing on the function of vitamin E in modulating cellular signaling and gene ex...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0524-2
更新日期:2017-02-01 00:00:00
abstract::Increased incidence of chronic kidney disease (CKD) with consecutive progression to end-stage renal disease represents a significant burden to healthcare systems. Renal tubulointerstitial fibrosis (TIF) is a classical hallmark of CKD and is well correlated with the loss of renal function. The bioactive lysophospholipi...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0518-0
更新日期:2016-12-01 00:00:00
abstract::Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-017-0560-6
更新日期:2016-08-01 00:00:00
abstract::Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA-induced protection against ischemia-reperfusion-induced myocardia...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-019-00670-y
更新日期:2019-08-01 00:00:00
abstract::Serotonin (5-HT) is one of the regulators of feeding in humans. Drugs acting on the serotoninergic system are used to treat bulimia nervosa and to enhance the effect of hypocaloric diets in overweight subjects. They act rapidly to normalise feeding when used to treat eating-related problems. To explore the role of the...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0188-5
更新日期:2013-03-01 00:00:00
abstract::Currently, there are no reports in the literature demonstrating any animal model that ingests one of the fattiest animal food source, the bovine brain. We hypothesized that a high-fat diet (HFD), based on dried bovine brain, could be used to develop an animal model possessing a spectrum of insulin resistance-related f...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0085-3
更新日期:2011-09-01 00:00:00
abstract::Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0087-1
更新日期:2011-09-01 00:00:00
abstract::The present study was addressed to determine whether the high expression of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in rat liver during the perinatal stage plays a role in the induction of liver lipoprotein lipase (LPL) expression and activity. Parallel increases in liver mRNA PPAR-alpha and LPL ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03168468
更新日期:2006-09-01 00:00:00
abstract::Although the human homologue of SND p102, p100 coactivator, was initially described as a nuclear protein, the p100 coactivator protein family members have non-nuclear localization in mammalian cells with active lipid handling, storage, and secretion. However, their role in lipid homeostasis remains unresolved. Here, w...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0011-0
更新日期:2010-03-01 00:00:00
abstract::We and others have demonstrated a protective role for pacing postconditioning (PPC) against ischemia/reperfusion (I/R) injury in the heart; however, the underlying mechanisms behind these protective effects are not completely understood. In this study, we wanted to further characterize PPC-mediated cardiac protection,...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0535-z
更新日期:2017-05-01 00:00:00
abstract::Glitazones are peroxisome proliferator-activated receptor gamma (PPARγ) agonists widely used as antidiabetic drugs also known as thiazolidinediones. Most of them exert other effects such as anti-inflammatory actions via mechanisms supposed to be independent from PPARγ activation (e.g., decreased plasma monocyte chemoa...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-014-0379-3
更新日期:2015-09-01 00:00:00
abstract::Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for the first time in the maternal-fetal interface. In cancer context, where high number of natural killer (NK) cells is described, the presence of HLA-G in its soluble form is thought to be essential for NK cells signaling. To evaluate intrace...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0005-y
更新日期:2010-03-01 00:00:00
abstract::The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations in endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated with obesity. The aim of this study was to investigate ER imbalance in the pancreas of a mic...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0476-6
更新日期:2016-06-01 00:00:00