Abstract：
:Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for the first time in the maternal-fetal interface. In cancer context, where high number of natural killer (NK) cells is described, the presence of HLA-G in its soluble form is thought to be essential for NK cells signaling. To evaluate intracellular signaling in NK cells upon HLA-G soluble forms stimulation, we investigate the role of soluble HLA-G (HLA-G5- and HLA-G1 shedding form) stimulation on classical nuclear factor (NF)-kappaB pathway activation. We reported that these two forms of soluble HLA-G could activate NF-kappaB in NK cells. NF-kappaB activation in NK cells does implicate neither phosphatidylinositol 3-kinase (PI3K) nor MEK (MAP kinase kinase) as demonstrated after specific inhibition experiments. We demonstrated elsewhere that NF-kappaB activation in NK cells is not implicated in cytotoxicity inhibition by HLA-G. Our findings may suggest the important role played by NF-kappaB activation after soluble HLA-G stimulation in other NK cells function.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Zidi I,Guillard C,Carosella ED,Moreau Pdoi
10.1007/s13105-010-0005-ysubject
Has Abstractpub_date
2010-03-01 00:00:00pages
39-46issue
1eissn
1138-7548issn
1877-8755journal_volume
66pub_type
杂志文章abstract：:To investigate the effects of pectin on cholesterol metabolism, normal rats were fed for three weeks a diet containing 2.5 or 5 % apple or orange pectin, or without pectin (control). Cholesterol concentrations were determined in faeces after 1, 2 and 3 weeks of treatment, and in liver and serum at the end of the exper...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Serotonin (5-HT) is one of the regulators of feeding in humans. Drugs acting on the serotoninergic system are used to treat bulimia nervosa and to enhance the effect of hypocaloric diets in overweight subjects. They act rapidly to normalise feeding when used to treat eating-related problems. To explore the role of the...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-012-0188-5
更新日期：2013-03-01 00:00:00
abstract：:Obesity is a leading health problem facing the modern world; however, no effective therapy for this health issue has yet been developed. A promising research direction to identify novel therapies to prevent obesity has emerged from discoveries on development and function of brown/brite adipocytes in mammals. Important...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-016-0536-y
更新日期：2017-02-01 00:00:00
abstract：:Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-017-0560-6
更新日期：2016-08-01 00:00:00
abstract：:Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-011-0087-1
更新日期：2011-09-01 00:00:00
abstract：:In traditional herbal medicine, Rock Tea (Jasonia glutinosa) is known for its prophylactic and therapeutic value in various disorders including arterial hypertension. However, the mechanism by which Rock Tea exerts blood pressure-lowering actions has not been elucidated yet. Our aim was to demonstrate vasorelaxing eff...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-015-0442-8
更新日期：2015-12-01 00:00:00
abstract：:Decline in oxygen availability experienced under hypobaric hypoxia (HH) mediates imbalance in lung fluid clearance and is a causative agent of acute lung injury. Here, we investigate the pathological events behind acute HH mediated lung injury and assess the therapeutic efficacy of nanocurcumin in its amelioration. We...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0515-3
更新日期：2016-12-01 00:00:00
abstract：:In order to observe the effects of nicotine on protein expression in rat vascular smooth muscle cells (SMCs), nicotine treated SMCs were studied by proteomic technologies combining two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF). Real-time RT-PCR was used to validate the differentially exp...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03168227
更新日期：2007-06-01 00:00:00
abstract：:The purpose of this study was to evaluate the effect of pomegranate (Punica granatum) in inhibiting and reversing the nephrotoxicity of carbon tetrachloride, a potent oxidative stress inducer which induces cellular kidney damage. Rats were intraperitoneally injected with carbon tetrachloride (2 mL/kg body weight) whic...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-012-0218-3
更新日期：2013-09-01 00:00:00
abstract：:Recently resveratrol, a compound naturally occurring in various plants, has been proposed as a potential anti-obesity compound. The aim of the present work was to analyse the effects of different doses of resveratrol on body fat and serum parameters in rats. Thirty-two male Sprague-Dawley rats were randomly divided in...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03185932
更新日期：2009-12-01 00:00:00
abstract：:Homocysteine (Hcy) is considered an independent risk factor for various cardiovascular diseases including atherosclerosis which is associated with lipid metabolism, inflammation, and oxidative stress. Results from our previous study suggested that Hcy-induced atherosclerosis could be reversed by Herpud1 knockout which...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-020-00741-5
更新日期：2020-08-01 00:00:00
abstract：:Differentiation of adipocytes and their aggregation to adipose tissue are critical for mammalian growth and development. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that play important roles in adipogenesis and lipid metabolism. miR-128-3p may contribute to adipose tissue development according t...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-018-0625-1
更新日期：2018-08-01 00:00:00
abstract：:Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satell...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-021-00787-z
更新日期：2021-01-26 00:00:00
abstract：:Cells are armed with a vast repertoire of antioxidant defence mechanisms to prevent the accumulation of oxidative damage. The cellular adaptive response is an important antioxidant mechanism against physiological and pathophysiological oxidative alterations in a cell's microenvironment. The aim of this paper was to st...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03165787
更新日期：2007-09-01 00:00:00
abstract：:Although pigs are adapted to starch-rich diets and have high turnover rates of glucose, very scarce information is available on the molecular basis of glucose transport. Therefore, the present study attempted a systematic screening for the presence of mRNA of glucose transport proteins in main organs of glucose absorp...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03180578
更新日期：2009-09-01 00:00:00
abstract：:Variations in the concentration of free amino acids in the muscle and plasma of trout submitted to 5 minutes of intense exercise have been studied. The responses of untrained fish and those trained performing the same type of exercise twice daily for 28 days are compared. Total amino acid concentrations in muscle tend...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:In order to transform cytosolic fructose-1,6-bisphosphatases (FBPase)(EC 3.1.3.11) into potential reductively-modulated chloroplast-type enzymes, we have constructed four chimeric FBPases, which display structural viability as deduced by previous modelling. In the X1-type BV1 and HL1 chimera the N-half of cytosolic su...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03168216
更新日期：2004-03-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-015-0438-4
更新日期：2015-12-01 00:00:00
abstract：:The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-016-0540-2
更新日期：2017-05-01 00:00:00
abstract：:Iron is a trace element and a structural part of antioxidant enzymes, and its requirements vary according to age and gender. We hypothesized that iron deficiency (ID) leads to an increase in free radicals which mainly affect the brain, and the severity of damage would therefore be dependent on age and gender. Two grou...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0529-x
更新日期：2017-02-01 00:00:00
abstract：:Previous studies from our laboratory have demonstrated that a single bout of moderate exercise stimulates macrophage function, increasing phagocytic capacity, and production of hydrogen peroxide and nitric oxide (NO˙) through nuclear factor kappa B activation. In this work, we investigated the role of α- and β-adrenor...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-013-0310-3
更新日期：2014-06-01 00:00:00
abstract：:In spite of a wide range of drugs being available in the market, treatment of arterial hypertension still remains a challenge, and new therapeutic strategies could be developed in order to improve the rate of success in controlling this disease. Since oxidative stress has gained importance in the last few years as one...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-010-0017-7
更新日期：2010-06-01 00:00:00
abstract：:The study investigates the effect of weight-maintaining high-sucrose (HSD) and high-fat (HFD) diets on plasma glucose and insulin concentrations in lean and obese women, and verifies the correlation between insulin profile and body composition. Lean (G1 group, n=6, BMI= 21.4 (20.2-22.8) kg/m2) and overweight/obese (G2...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03168238
更新日期：2008-06-01 00:00:00
abstract：:In response to stress, the hypothalamus releases cortiticotropin releasing hormone (CRH) that travels to the anterior pituitary, where it stimulates the release of adrenocorticotropic hormone (ACTH). ACTH travels to the adrenal cortex, where it stimulates the release of cortisol and other steroids that liberate energy...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-012-0227-2
更新日期：2013-09-01 00:00:00
abstract：:Glitazones are peroxisome proliferator-activated receptor gamma (PPARγ) agonists widely used as antidiabetic drugs also known as thiazolidinediones. Most of them exert other effects such as anti-inflammatory actions via mechanisms supposed to be independent from PPARγ activation (e.g., decreased plasma monocyte chemoa...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-014-0379-3
更新日期：2015-09-01 00:00:00
abstract：:The number of patients that suffer some type of spinal cord lesion in recent years are high and have increased because of factors such as traffic accidents. Although their life expectancy has increased, cardiovascular illnesses is one of the main causes of morbidity and mortality. Since the degree of physical fitness ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179863
更新日期：2003-03-01 00:00:00
abstract：:Opioid receptors play an important role in modulation of hyperalgesia in inflamed tissues, but chronic morphine application induces such side effects as tolerance. There is near communications between cytokines and mu opioid receptor expression. This study was aimed to assess the role of serum IL-10 in morphine tolera...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-014-0330-7
更新日期：2014-06-01 00:00:00
abstract：:In the present work, we have evaluated the effect of an acute addition of melatonin on cholecystokinin octapeptide (CCK-8)-evoked Ca(2+) signals and amylase secretion in mouse pancreatic acinar cells. For this purpose, freshly isolated mouse pancreatic acinar cells were loaded with fura-2 to study intracellular free C...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-013-0267-2
更新日期：2013-12-01 00:00:00
abstract：:Several studies have suggested that oxidative stress might cause and aggravate the inflammatory state associated with obesity and could be the link between excessive weight gain and its related disorders such as insulin resistance and cardiovascular diseases. Thus, antioxidant treatment has been proposed as a therapy ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03165968
更新日期：2009-03-01 00:00:00
abstract：:Total level of O-acetyl-L-serine(thiol)lyase (OASTL) activity observed in Monoraphidium braunii fed-repleted cells decreases up to 40% after 24 h the carbon source was removed from the culture; however, no significant change in the activity is observed in N-starved cells. On the other hand, sulfur starvation induces O...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
