Abstract:
:Iron is a trace element and a structural part of antioxidant enzymes, and its requirements vary according to age and gender. We hypothesized that iron deficiency (ID) leads to an increase in free radicals which mainly affect the brain, and the severity of damage would therefore be dependent on age and gender. Two groups of Wistar rats were evaluated evolutionarily: 100 rats (50 males; 50 females) with ID diet and 100 rats (50 males; 50 females) with standard diet. Both groups were offspring from mothers who were previously under the same dietary intervention. The ages studied roughly correspond to stages of human development: birth (0 postnatal day "PND" in rats), childhood (21 PND), early adolescence (42 PND), late adolescence (56 PND), and adulthood (70 PND). The following biomarkers in the brain, blood, and liver were analyzed: lipid peroxidation products (LPO), protein carbonyl content and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. It was demonstrated that ID subjects are born with high levels of LPO in the brain and low antioxidant activity, the damage being more severe in males. After birth, antioxidant defense focuses on the central level (brain) in ID females and on the peripheral level (blood and liver) in ID males. In two critical stages of development, birth and late adolescence, antioxidant protection is insufficient to counteract oxidative damage in ID subjects. Moreover, we observed that the variability of results in the literature on oxidative stress and ID comes from gender and age of the subjects under study. With this, we can establish patterns and exact moments to carry out studies or treatments.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Vieyra-Reyes P,Millán-Aldaco D,Palomero-Rivero M,Jiménez-Garcés C,Hernández-González M,Caballero-Villarraso Jdoi
10.1007/s13105-016-0529-xsubject
Has Abstractpub_date
2017-02-01 00:00:00pages
99-110issue
1eissn
1138-7548issn
1877-8755pii
10.1007/s13105-016-0529-xjournal_volume
73pub_type
杂志文章abstract::The question as to whether A3 adenosine receptor (A3AR) agonists, N (6)-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N (6)-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations with or without the involvement of A3AR has been a controv...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0222-7
更新日期:2013-09-01 00:00:00
abstract::Platelets play an essential role in primary hemostasis and in thrombotic events, particularly in arterial vessels, as rheological conditions originate closer interactions between platelets and endothelium than lower shear rates. In response to vascular injury, platelets adhere to the subendothelial matrix by membrane ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/BF03179804
更新日期:2000-12-01 00:00:00
abstract::The human body is made of some 250 different cell types. From them, only a small subset of cell types is able to produce histamine. They include some neurons, enterochromaffin-like cells, gastrin-containing cells, mast cells, basophils, and monocytes/macrophages, among others. In spite of the reduced number of these h...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-010-0033-7
更新日期:2010-09-01 00:00:00
abstract::Currently, there are no reports in the literature demonstrating any animal model that ingests one of the fattiest animal food source, the bovine brain. We hypothesized that a high-fat diet (HFD), based on dried bovine brain, could be used to develop an animal model possessing a spectrum of insulin resistance-related f...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-011-0085-3
更新日期:2011-09-01 00:00:00
abstract::Two groups of rats were fed on diets with protein from a marine specie holothuria (Holothuria forskali) or casein (for the control group) during 16 days with the aim of assessing the nutritional value of the holothuria protein. Several serum lipid levels were also determined. The results of the nutritive parameters in...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179775
更新日期:2000-03-01 00:00:00
abstract::Opioid receptors play an important role in modulation of hyperalgesia in inflamed tissues, but chronic morphine application induces such side effects as tolerance. There is near communications between cytokines and mu opioid receptor expression. This study was aimed to assess the role of serum IL-10 in morphine tolera...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-014-0330-7
更新日期:2014-06-01 00:00:00
abstract::The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations in endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated with obesity. The aim of this study was to investigate ER imbalance in the pancreas of a mic...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0476-6
更新日期:2016-06-01 00:00:00
abstract::GLUT2 is a facilitative glucose transporter located in the plasma membrane of the liver, pancreatic, intestinal, kidney cells as well as in the portal and the hypothalamus areas. Due to its low affinity and high capacity, GLUT2 transports dietary sugars, glucose, fructose and galactose in a large range of physiologica...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/BF03168378
更新日期:2005-12-01 00:00:00
abstract::The number of patients that suffer some type of spinal cord lesion in recent years are high and have increased because of factors such as traffic accidents. Although their life expectancy has increased, cardiovascular illnesses is one of the main causes of morbidity and mortality. Since the degree of physical fitness ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03179863
更新日期:2003-03-01 00:00:00
abstract::Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-017-0560-6
更新日期:2016-08-01 00:00:00
abstract::In order to evaluate the expression of nuclear receptors at the peripheral level in obese subjects, messenger RNA (mRNA) levels of different isoforms of retinoic acid receptor (RAR), triiodothyronine (TR), and peroxisome proliferator-activated receptor (PPAR) were determined and compared in peripheral mononuclear bloo...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0006-x
更新日期:2010-03-01 00:00:00
abstract::Adiponectin, a hormone produced by adipocytes, is involved in glucose metabolism and insulin sensitivity. The production of this adipokine is impaired in obesity and insulin resistance. Eicosapentaenoic acid (EPA) is a dietary n-3 polyunsaturated fatty acid that improves insulin sensitivity in several models of obesit...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03174067
更新日期:2006-06-01 00:00:00
abstract::The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-019-00673-9
更新日期:2019-08-01 00:00:00
abstract::Obesity is a leading health problem facing the modern world; however, no effective therapy for this health issue has yet been developed. A promising research direction to identify novel therapies to prevent obesity has emerged from discoveries on development and function of brown/brite adipocytes in mammals. Important...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-016-0536-y
更新日期:2017-02-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of pomegranate (Punica granatum) in inhibiting and reversing the nephrotoxicity of carbon tetrachloride, a potent oxidative stress inducer which induces cellular kidney damage. Rats were intraperitoneally injected with carbon tetrachloride (2 mL/kg body weight) whic...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-012-0218-3
更新日期:2013-09-01 00:00:00
abstract::In order to transform cytosolic fructose-1,6-bisphosphatases (FBPase)(EC 3.1.3.11) into potential reductively-modulated chloroplast-type enzymes, we have constructed four chimeric FBPases, which display structural viability as deduced by previous modelling. In the X1-type BV1 and HL1 chimera the N-half of cytosolic su...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03168216
更新日期:2004-03-01 00:00:00
abstract::Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for the first time in the maternal-fetal interface. In cancer context, where high number of natural killer (NK) cells is described, the presence of HLA-G in its soluble form is thought to be essential for NK cells signaling. To evaluate intrace...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-010-0005-y
更新日期:2010-03-01 00:00:00
abstract::Diabetes is a risk factor for cardiovascular disease that has a multifactorial etiology, with oxidative stress as an important component. Our previous observation of a significant diabetes-related increase in rat cardiac catalase (CAT) activity suggested that CAT could play a major role in delaying the development of ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-014-0363-y
更新日期:2014-12-01 00:00:00
abstract::Previous studies from our laboratory have demonstrated that a single bout of moderate exercise stimulates macrophage function, increasing phagocytic capacity, and production of hydrogen peroxide and nitric oxide (NO˙) through nuclear factor kappa B activation. In this work, we investigated the role of α- and β-adrenor...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-013-0310-3
更新日期:2014-06-01 00:00:00
abstract::Gut bacteria play an important role in several metabolic processes and human diseases, such as obesity and accompanying co-morbidities, such as fatty liver disease, insulin resistance/diabetes, and cardiovascular events. Among other factors, dietary patterns, probiotics, prebiotics, synbiotics, antibiotics, and non-di...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-017-0564-2
更新日期:2018-02-01 00:00:00
abstract::The present study was designed to evaluate the cardioprotective effect of Tunisian flaxseed oil (Linum usitatissimum) against isoproterenol-induced myocardial infarction in rats by studying hypertensive and cardiac damage markers especially electrocardiographic changes and troponin T serum level. In vitro, the extract...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-015-0411-2
更新日期:2015-06-01 00:00:00
abstract::To investigate the effects of pectin on cholesterol metabolism, normal rats were fed for three weeks a diet containing 2.5 or 5 % apple or orange pectin, or without pectin (control). Cholesterol concentrations were determined in faeces after 1, 2 and 3 weeks of treatment, and in liver and serum at the end of the exper...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Previous studies have shown that stromal interaction molecule1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) contributes to intracellular Ca2+ accumulation in H9C2 cells subjected to hypoxia/reoxygenation(H/R) injury. The aim of the present study was to investigate the effect of resveratrol on STIM1-mediated intra...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-019-00704-5
更新日期:2019-11-01 00:00:00
abstract::Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satell...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s13105-021-00787-z
更新日期:2021-01-26 00:00:00
abstract::The objective of the present study was to assess the usefulness and accuracy of different anthropometric measurements in the diagnosis of abdominal visceral obesity in overweight/obese women attending to age and menopausal status. The secondary objective was to evaluate the usefulness of waist circumference (WC) in tw...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165753
更新日期:2006-12-01 00:00:00
abstract::Variations in the concentration of free amino acids in the muscle and plasma of trout submitted to 5 minutes of intense exercise have been studied. The responses of untrained fish and those trained performing the same type of exercise twice daily for 28 days are compared. Total amino acid concentrations in muscle tend...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Activation of 5' adenosine monophosphate-activated protein kinase (AMPK) with aminoimidazole carboxamide ribonucleotide (AICAR) increases skeletal muscle glucose uptake and fatty acid oxidation. The purpose of these experiments was to utilize AICAR to enhance palmitate consumption by mitochondria in cultured skeletal ...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-013-0269-0
更新日期:2013-12-01 00:00:00
abstract::Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathin...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-020-00761-1
更新日期:2020-11-01 00:00:00
abstract::In the absence of progesterone (P), the anti-P at the receptor RU486 reduces basal and GnRH-stimulated LH secretion both in vivo and in vitro, demonstrating the existence of a ligand-independent activation of progesterone receptor (LIAPR). The aim of the present study was to determine which component of the intracellu...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF03165804
更新日期:2006-03-01 00:00:00
abstract::Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...
journal_title:Journal of physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s13105-016-0497-1
更新日期:2016-12-01 00:00:00