Abstract：
:Platelets play an essential role in primary hemostasis and in thrombotic events, particularly in arterial vessels, as rheological conditions originate closer interactions between platelets and endothelium than lower shear rates. In response to vascular injury, platelets adhere to the subendothelial matrix by membrane receptors potentiating the generation of thrombin, become activated, and a series of biochemical processes induce platelet aggregation and liberation of intracellular metabolic products to the extracelular medium. Among platelet receptors, glycoprotein (GP) Ib/IX/V complex is peculiar, as it binds adhesive proteins, mainly von Willebrand factor (vWF), and thrombin, the main platelet agonist. Platelet adhesion and subsequent aggregation under conditions of high shear flow, essentially relies upon this receptor's capacity of binding to the subendothelial matrix, initiating signal transduction. Two proteins associated to GP Ib/IX/V, actin-binding protein (ABP) 280 and 14-3-3zeta, are potential mediators of signal transduction by the complex, but their specific contribution in this process is not yet fully understood. Additionally, two proteins implicated in signal transduction by immune stimuli, FcgammaRIIA and FcR gamma-chain, associate with GPIb/IX/V complex, and increasing data indicate a potential role in GPIbalpha mediated signal transduction.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Rivera J,Lozano ML,Corral J,González-Conejero R,Martínez C,Vicente Vdoi
10.1007/BF03179804subject
Has Abstractpub_date
2000-12-01 00:00:00pages
355-65issue
4eissn
1138-7548issn
1877-8755journal_volume
56pub_type
杂志文章,评审abstract：:In order to evaluate the expression of nuclear receptors at the peripheral level in obese subjects, messenger RNA (mRNA) levels of different isoforms of retinoic acid receptor (RAR), triiodothyronine (TR), and peroxisome proliferator-activated receptor (PPAR) were determined and compared in peripheral mononuclear bloo...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-010-0006-x
更新日期：2010-03-01 00:00:00
abstract：:Increased incidence of chronic kidney disease (CKD) with consecutive progression to end-stage renal disease represents a significant burden to healthcare systems. Renal tubulointerstitial fibrosis (TIF) is a classical hallmark of CKD and is well correlated with the loss of renal function. The bioactive lysophospholipi...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0518-0
更新日期：2016-12-01 00:00:00
abstract：:Low shear stress (LSS) occurs in areas where atherosclerosis is prevalent. Many studies have revealed that signal transducer and activator of transcription 1 (STAT1) plays a significant role in cardiovascular disease. Nonetheless, the mechanism underlying the connection between STAT1 and LSS is not fully understood. T...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-020-00729-1
更新日期：2020-02-01 00:00:00
abstract：:Decline in oxygen availability experienced under hypobaric hypoxia (HH) mediates imbalance in lung fluid clearance and is a causative agent of acute lung injury. Here, we investigate the pathological events behind acute HH mediated lung injury and assess the therapeutic efficacy of nanocurcumin in its amelioration. We...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0515-3
更新日期：2016-12-01 00:00:00
abstract：:Total level of O-acetyl-L-serine(thiol)lyase (OASTL) activity observed in Monoraphidium braunii fed-repleted cells decreases up to 40% after 24 h the carbon source was removed from the culture; however, no significant change in the activity is observed in N-starved cells. On the other hand, sulfur starvation induces O...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:The present review aims to illustrate current knowledge about the efficacy of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) in treating/preventing several metabolic pathologies. We reviewed systematically the published evidence on the effectiveness of n-3 LC-PUFAs fish consumption or n-3 LC-PUFAs suppl...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-013-0265-4
更新日期：2013-09-01 00:00:00
abstract：:A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxida...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-018-0633-1
更新日期：2018-08-01 00:00:00
abstract：:This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradio...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-010-0008-8
更新日期：2010-03-01 00:00:00
abstract：:In the present work, we have evaluated the effect of an acute addition of melatonin on cholecystokinin octapeptide (CCK-8)-evoked Ca(2+) signals and amylase secretion in mouse pancreatic acinar cells. For this purpose, freshly isolated mouse pancreatic acinar cells were loaded with fura-2 to study intracellular free C...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-013-0267-2
更新日期：2013-12-01 00:00:00
abstract：:Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-016-0497-1
更新日期：2016-12-01 00:00:00
abstract：:The present study was designed to evaluate the cardioprotective effect of Tunisian flaxseed oil (Linum usitatissimum) against isoproterenol-induced myocardial infarction in rats by studying hypertensive and cardiac damage markers especially electrocardiographic changes and troponin T serum level. In vitro, the extract...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-015-0411-2
更新日期：2015-06-01 00:00:00
abstract：:In pregnancy there occurs maternal tolerance to the foetus. Several mechanisms have been proposed to explain this phenomenon. The main immune population in the decidua are macrophages and natural killer cells, but with some "special" suppressor characteristics. There is also a predominant TH2 response. The non classic...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/BF03167033
更新日期：2004-09-01 00:00:00
abstract：:Two groups of rats were fed on diets with protein from a marine specie holothuria (Holothuria forskali) or casein (for the control group) during 16 days with the aim of assessing the nutritional value of the holothuria protein. Several serum lipid levels were also determined. The results of the nutritive parameters in...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179775
更新日期：2000-03-01 00:00:00
abstract：:S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimul...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-015-0418-8
更新日期：2015-09-01 00:00:00
abstract：:Activation of 5' adenosine monophosphate-activated protein kinase (AMPK) with aminoimidazole carboxamide ribonucleotide (AICAR) increases skeletal muscle glucose uptake and fatty acid oxidation. The purpose of these experiments was to utilize AICAR to enhance palmitate consumption by mitochondria in cultured skeletal ...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-013-0269-0
更新日期：2013-12-01 00:00:00
abstract：:Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-011-0087-1
更新日期：2011-09-01 00:00:00
abstract：:Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for interventions. In this review, we explored the Hippo signalling pathway which plays an essential role in human oncogenesis and the pathway's influence on myogenesis and satell...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-021-00787-z
更新日期：2021-01-26 00:00:00
abstract：:The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-019-00673-9
更新日期：2019-08-01 00:00:00
abstract：:Opioid receptors play an important role in modulation of hyperalgesia in inflamed tissues, but chronic morphine application induces such side effects as tolerance. There is near communications between cytokines and mu opioid receptor expression. This study was aimed to assess the role of serum IL-10 in morphine tolera...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-014-0330-7
更新日期：2014-06-01 00:00:00
abstract：:Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathin...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-020-00761-1
更新日期：2020-11-01 00:00:00
abstract：:In order to observe the effects of nicotine on protein expression in rat vascular smooth muscle cells (SMCs), nicotine treated SMCs were studied by proteomic technologies combining two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF). Real-time RT-PCR was used to validate the differentially exp...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03168227
更新日期：2007-06-01 00:00:00
abstract：:To investigate the effects of pectin on cholesterol metabolism, normal rats were fed for three weeks a diet containing 2.5 or 5 % apple or orange pectin, or without pectin (control). Cholesterol concentrations were determined in faeces after 1, 2 and 3 weeks of treatment, and in liver and serum at the end of the exper...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:In order to obtain healthier goat milk as far as its fat composition is concerned, milk production and composition trials were carried out with Granadina goats kept in semi-extensive breeding conditions. The animals were feeding indoors with a concentrate supplemented or not with 7% of fat conveniently protected again...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179791
更新日期：2000-09-01 00:00:00
abstract：:Due to its noninvasive, convenient, and practical nature, salivary testosterone (sal-T) and cortisol (sal-C) are frequently used in a clinical and applied setting. However, few studies report biological and analytical error and even fewer report the 'critical difference' which is the change required before a true biol...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13105-014-0368-6
更新日期：2014-12-01 00:00:00
abstract：:While the unequivocal pattern of endothelial nitric oxide synthase (eNOS) inhibition in cardiovascular control is recognized, the role of NO produced by neuronal NOS (nNOS) remains unclear. The aim of this study was to compare the effects of chronic treatment with 7-nitroindazole (7-NI, nNOS inhibitor) and N(G)-nitro-...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-014-0343-2
更新日期：2014-09-01 00:00:00
abstract：:The question as to whether A3 adenosine receptor (A3AR) agonists, N (6)-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N (6)-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations with or without the involvement of A3AR has been a controv...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-012-0222-7
更新日期：2013-09-01 00:00:00
abstract：:Serotonin (5-HT) is one of the regulators of feeding in humans. Drugs acting on the serotoninergic system are used to treat bulimia nervosa and to enhance the effect of hypocaloric diets in overweight subjects. They act rapidly to normalise feeding when used to treat eating-related problems. To explore the role of the...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-012-0188-5
更新日期：2013-03-01 00:00:00
abstract：:Growth hormone plays a key role in the maturation and maintenance of the immune response, however, the effects of chronic high circulating concentrations of the hormone on the immune system is poorly understood. Transgenic mice overexpressing bovine growth hormone (b-GH) gene, fused to the rat phosphoenolpyruvate carb...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03179853
更新日期：2002-09-01 00:00:00
abstract：:Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for the first time in the maternal-fetal interface. In cancer context, where high number of natural killer (NK) cells is described, the presence of HLA-G in its soluble form is thought to be essential for NK cells signaling. To evaluate intrace...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/s13105-010-0005-y
更新日期：2010-03-01 00:00:00
abstract：:In order to transform cytosolic fructose-1,6-bisphosphatases (FBPase)(EC 3.1.3.11) into potential reductively-modulated chloroplast-type enzymes, we have constructed four chimeric FBPases, which display structural viability as deduced by previous modelling. In the X1-type BV1 and HL1 chimera the N-half of cytosolic su...
journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：10.1007/BF03168216
更新日期：2004-03-01 00:00:00
