Abstract：
:A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxidants and reduce oxidative damage. Yet, strenuous exercise perturbs the antioxidant system by increasing the reactive oxygen species (ROS) content. These alterations in the cellular environment seem to occur in an exercise type-dependent manner. The source of ROS generation during exercise is debatable, but now it is well established that both contracting and relaxing skeletal muscles generate reactive oxygen species and reactive nitrogen species. In particular, exercises of higher intensity and longer duration can cause oxidative damage to lipids, proteins, and nucleotides in myocytes. In this review, we summarize the ROS effects and interplay of antioxidants in skeletal muscle during physical exercise. Additionally, we discuss how ROS-mediated signaling influences physical exercise in antioxidant system.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Thirupathi A,Pinho RAdoi
10.1007/s13105-018-0633-1subject
Has Abstractpub_date
2018-08-01 00:00:00pages
359-367issue
3eissn
1138-7548issn
1877-8755pii
10.1007/s13105-018-0633-1journal_volume
74pub_type
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