Abstract：
:In order to evaluate the expression of nuclear receptors at the peripheral level in obese subjects, messenger RNA (mRNA) levels of different isoforms of retinoic acid receptor (RAR), triiodothyronine (TR), and peroxisome proliferator-activated receptor (PPAR) were determined and compared in peripheral mononuclear blood cells (PBMC) and subcutaneous white adipose tissue (SWAT). Twelve lean subjects and 68 obese subjects divided into weight gain (WG), weight-stable (WS), and weight loss (WL) groups were studied. Nuclear receptor mRNA levels were assessed in PBMC and SWAT using a quantitative real-time reverse transcription polymerase chain reaction method. mRNA levels of RARgamma were significantly lower in PBMC of obese subjects (WG -19%, WS -30%, and WL -24.7%) as in SWAT of WG (-50%). Lower mRNA levels of TRbeta were observed in PBMC and SWAT of WG (-50.7% and -28%, respectively) just as for TRalpha in PBMC of WG (-19%). In contrast, retinoid X receptors alpha (RXRalpha) and RARalpha mRNA levels were higher in PBMC of obese subjects (+53% and +54.5% in WG, +56% and +67% in WS, and +68% and +49.7% in WL, respectively), while expression of RXRalpha was lower in SWAT of WG (-24.5%). As for PPARgamma, its mRNA level was significantly higher in PBMC of WG subjects (+34%) while its expression was not modified in SWAT, contrary to the PPARgamma2 isoform which was significantly higher. These data show that in both adipose tissue and blood compartment of obese subjects, expressions of RARgamma and TRbeta were downregulated. Thus, we suggest that the expression in PBMC of obese subjects may constitute new cellular indicators of nuclear receptor retinoid and thyroid status.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Bairras C,Redonnet A,Dabadie H,Gin H,Atgie C,Pallet V,Higueret P,Noël-Suberville Cdoi
10.1007/s13105-010-0006-xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
29-37issue
1eissn
1138-7548issn
1877-8755journal_volume
66pub_type
杂志文章abstract：:Regular physical exercise is recognized as a nonpharmacological therapeutic strategy in the treatment of metabolic syndrome, and has been proposed for improving obesity, diabetic status, insulin resistance, and immune response. The aim of the present study was to evaluate the effect of a regular exercise program (trea...
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journal_title：Journal of physiology and biochemistry
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journal_title：Journal of physiology and biochemistry
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
doi：10.1007/s13105-010-0033-7
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章,评审
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journal_title：Journal of physiology and biochemistry
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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