Adipose-derived exosomes deliver miR-23a/b to regulate tumor growth in hepatocellular cancer by targeting the VHL/HIF axis.


:Adipose tissue has long been considered to be involved in tumor progression. However, the adipocyte-secreted molecular determinants that regulate hepatocellular cancer progression have not been defined yet. In this study, the expression pattern of exosome miRNAs in hepatocellular carcinoma (HCC) patients with high body fat ratio (BFR) were identified by using low-density microarray. And the targets of exosome-miRNAs in HCC cells were predicted by bioinformatics methods and verified by in vitro as well as in vivo experiments. Here, we show that microRNA-23a/b (miR-23a/b) was significantly upregulated in both serum exosomes and tumor tissues of HCC patients with a high body fat ratio than low BFR. Subsequently, in vitro studies suggested that miR-23a/b was most likely to be derived from adipocytes and was transported into cancer cells via exosomes, thus promoting HCC cell growth and migration. Meanwhile, exosome miR-23a and miR-23b confer chemoresistance by targeting the von Hippel-Lindau/hypoxia-inducible factor axis. Our study provides evidence in that high BFR-related exosome miR23-a/b is a promising target for future treatment of HCC.


J Physiol Biochem


Liu Y,Tan J,Ou S,Chen J,Chen L




Has Abstract


2019-08-01 00:00:00














  • Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway.

    abstract::Homocysteine (Hcy) is considered an independent risk factor for various cardiovascular diseases including atherosclerosis which is associated with lipid metabolism, inflammation, and oxidative stress. Results from our previous study suggested that Hcy-induced atherosclerosis could be reversed by Herpud1 knockout which...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Gao F,Zhang J,Ni T,Lin N,Lin H,Luo H,Guo H,Chi J

    更新日期:2020-08-01 00:00:00

  • Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium.

    abstract::The weight loss observed in consumers of extracts of Citrus aurantium (bitter orange) has been tentatively attributed to the lipolytic and thermogenic effects of the alkaloids abundant in the unripe fruit. Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus me...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Mercader J,Wanecq E,Chen J,Carpéné C

    更新日期:2011-09-01 00:00:00

  • Effects of raloxifene and estradiol on bone turnover parameters in intact and ovariectomized rats.

    abstract::This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradio...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Canpolat S,Tug N,Seyran AD,Kumru S,Yilmaz B

    更新日期:2010-03-01 00:00:00

  • Does nitric oxide play a role in maternal tolerance towards the foetus?

    abstract::In pregnancy there occurs maternal tolerance to the foetus. Several mechanisms have been proposed to explain this phenomenon. The main immune population in the decidua are macrophages and natural killer cells, but with some "special" suppressor characteristics. There is also a predominant TH2 response. The non classic...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审


    authors: González A,López AS,Alegre E,Alcázar JL,López-Moratalla N

    更新日期:2004-09-01 00:00:00

  • Characterization of gut microbiota composition in HIV-infected patients with metabolic syndrome.

    abstract::The presence of metabolic syndrome (MS) per se or its separated components in HIV-infected patients contributes to an accelerated aging and increased cardiovascular risk. Gut microbiota (GM) dysbiosis has been linked with chronic inflammation associated with MS in a general non-infected population. However, no studies...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Villanueva-Millán MJ,Pérez-Matute P,Recio-Fernández E,Lezana Rosales JM,Oteo JA

    更新日期:2019-08-01 00:00:00

  • Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats.

    abstract::Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Fernández-Galilea M,Pérez-Matute P,Prieto-Hontoria P,Martínez JA,Moreno-Aliaga MJ

    更新日期:2011-09-01 00:00:00

  • Plasma lactate and leukocyte mitochondrial DNA copy number as biomarkers of insulin sensitivity in non-diabetic women.

    abstract::High plasma lactate levels have been associated with reduced mitochondrial respiratory capacity and increased type 2 diabetes risk, while mitochondrial DNA (mtDNA) copy number has been proposed as a biomarker of mitochondrial function linked to glucose homeostasis. The aim of this study was to evaluate the association...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Santos JL,Cataldo LR,Cortés-Rivera C,Bravo C,Díaz-Casanova L,Martínez JA,Milagro FI,Galgani J

    更新日期:2019-08-01 00:00:00

  • SHBG, plasma, and urinary androgens in weight lifters after a strength training.

    abstract::Previous studies with different results have suggested that total and bioavailable testosterone levels are modified by physical exercise. Such changes may be related to modifications in cortisol levels and could be reflected in some urine androgens. To determine how weight lifting training may affect serum and urinary...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Maynar M,Timon R,González A,Olcina G,Toribio F,Maynar JI,Caballero MJ

    更新日期:2010-06-01 00:00:00

  • Genistein effects on Ca2+ handling in human umbilical artery: inhibition of sarcoplasmic reticulum Ca2+ release and of voltage-operated Ca2+ channels.

    abstract::Isoflavones are a group of natural phytoestrogens including the compound genistein. Health beneficial effects have been attributed to the consumption of this compound, but the fact that it has estrogen-like activity has raised doubts regarding its potential risk in infants, newborns, or in the fetus and placenta durin...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Speroni F,Rebolledo A,Salemme S,Roldán-Palomo R,Rimorini L,Añón MC,Spinillo A,Tanzi F,Milesi V

    更新日期:2009-06-01 00:00:00

  • About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs.

    abstract::Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA-induced protection against ischemia-reperfusion-induced myocardia...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审


    authors: Demaison L,Leger T,Vergely C,Rochette L,Azarnoush K

    更新日期:2019-08-01 00:00:00

  • Anti-proliferative effects of paeonol on human prostate cancer cell lines DU145 and PC-3.

    abstract::Paeonol (Pae) is the main active ingredient from the root bark of Paeonia moutan and the grass of Radix Cynanchi Paniculati. Numerous reports indicate that Pae effectively inhibits several types of cancer lines. In this study, we report that Pae hinders prostate cancer growth both in vivo and in vitro. Human prostate ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Xu Y,Zhu JY,Lei ZM,Wan LJ,Zhu XW,Ye F,Tong YY

    更新日期:2017-05-01 00:00:00

  • S-resistin, a non secretable resistin isoform, impairs the insulin signalling pathway in 3T3-L1 adipocytes.

    abstract::S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimul...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Rodríguez M,Moltó E,Aguado L,Gallardo N,Andrés A,Arribas C

    更新日期:2015-09-01 00:00:00

  • Rock Tea extract (Jasonia glutinosa) relaxes rat aortic smooth muscle by inhibition of L-type Ca(2+) channels.

    abstract::In traditional herbal medicine, Rock Tea (Jasonia glutinosa) is known for its prophylactic and therapeutic value in various disorders including arterial hypertension. However, the mechanism by which Rock Tea exerts blood pressure-lowering actions has not been elucidated yet. Our aim was to demonstrate vasorelaxing eff...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Valero MS,Oliván-Viguera A,Garrido I,Langa E,Berzosa C,López V,Gómez-Rincón C,Murillo MD,Köhler R

    更新日期:2015-12-01 00:00:00

  • Interaction between irbesartan, peroxisome proliferator-activated receptor (PPAR-γ), and adiponectin in the regulation of blood pressure and renal function in spontaneously hypertensive rats.

    abstract::Adiponectin exerts vasodilatory effects. Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activity and increases circulating adiponectin. This study explored the effect of irbesartan alone and in combination with adiponectin on blood press...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Afzal S,Sattar MA,Johns EJ,Abdulla MH,Akhtar S,Hashmi F,Abdullah NA

    更新日期:2016-12-01 00:00:00

  • An iron-deficient diet during development induces oxidative stress in relation to age and gender in Wistar rats.

    abstract::Iron is a trace element and a structural part of antioxidant enzymes, and its requirements vary according to age and gender. We hypothesized that iron deficiency (ID) leads to an increase in free radicals which mainly affect the brain, and the severity of damage would therefore be dependent on age and gender. Two grou...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Vieyra-Reyes P,Millán-Aldaco D,Palomero-Rivero M,Jiménez-Garcés C,Hernández-González M,Caballero-Villarraso J

    更新日期:2017-02-01 00:00:00

  • Metabolic risk-factor clustering estimation in obese children.

    abstract::The purpose of this study was to apply the new approach for Metabolic Individual Risk-factor And Clustering Estimation (MIRACLE) score in a group of Spanish obese children and adolescents and to describe its relationship with other metabolic risk factors. 153 children with simple obesity were studied: 79 males and 74 ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Bueno G,Moreno LA,Bueno O,Morales J,Pérez-Roche T,Garagorri JM,Bueno M

    更新日期:2007-12-01 00:00:00

  • The role of GLUT2 in dietary sugar handling.

    abstract::GLUT2 is a facilitative glucose transporter located in the plasma membrane of the liver, pancreatic, intestinal, kidney cells as well as in the portal and the hypothalamus areas. Due to its low affinity and high capacity, GLUT2 transports dietary sugars, glucose, fructose and galactose in a large range of physiologica...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审


    authors: Leturque A,Brot-Laroche E,Le Gall M,Stolarczyk E,Tobin V

    更新日期:2005-12-01 00:00:00

  • Targeting of histamine producing cells by EGCG: a green dart against inflammation?

    abstract::The human body is made of some 250 different cell types. From them, only a small subset of cell types is able to produce histamine. They include some neurons, enterochromaffin-like cells, gastrin-containing cells, mast cells, basophils, and monocytes/macrophages, among others. In spite of the reduced number of these h...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审


    authors: Melgarejo E,Medina MA,Sánchez-Jiménez F,Urdiales JL

    更新日期:2010-09-01 00:00:00

  • RARgamma and TRbeta expressions are decreased in PBMC and SWAT of obese subjects in weight gain.

    abstract::In order to evaluate the expression of nuclear receptors at the peripheral level in obese subjects, messenger RNA (mRNA) levels of different isoforms of retinoic acid receptor (RAR), triiodothyronine (TR), and peroxisome proliferator-activated receptor (PPAR) were determined and compared in peripheral mononuclear bloo...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Bairras C,Redonnet A,Dabadie H,Gin H,Atgie C,Pallet V,Higueret P,Noël-Suberville C

    更新日期:2010-03-01 00:00:00

  • Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats.

    abstract::Pouteria campechiana (Kunth) Baehni. is used as a remedy for coronary trouble, liver disorders, epilepsy, skin disease, and ulcer. Therefore, the present study aims to investigate the antioxidant and hepatoprotective effect of polyphenolic-rich P. campechiana fruit extract against acetaminophen-intoxicated rats. Total...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Aseervatham GS,Sivasudha T,Sasikumar JM,Christabel PH,Jeyadevi R,Ananth DA

    更新日期:2014-03-01 00:00:00

  • Association of SND1 protein to low density lipid droplets in liver steatosis.

    abstract::Although the human homologue of SND p102, p100 coactivator, was initially described as a nuclear protein, the p100 coactivator protein family members have non-nuclear localization in mammalian cells with active lipid handling, storage, and secretion. However, their role in lipid homeostasis remains unresolved. Here, w...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Garcia-Arcos I,Rueda Y,González-Kother P,Palacios L,Ochoa B,Fresnedo O

    更新日期:2010-03-01 00:00:00

  • Effect of nitrate and L-arginine therapy on nitric oxide levels in serum, heart, and aorta of fetal hypothyroid rats.

    abstract::Reduced nitric oxide availability and a heterogeneous pattern of nitric oxide synthase activity in some tissues have been reported in hypothyroidism. This study aimed at determining the effects of oral nitrate and L-arginine administration on serum, heart, and aorta nitric oxide metabolite concentrations in fetal hypo...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Ghasemi A,Mehrazin F,Zahediasl S

    更新日期:2013-12-01 00:00:00

  • Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet.

    abstract::Recently resveratrol, a compound naturally occurring in various plants, has been proposed as a potential anti-obesity compound. The aim of the present work was to analyse the effects of different doses of resveratrol on body fat and serum parameters in rats. Thirty-two male Sprague-Dawley rats were randomly divided in...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Macarulla MT,Alberdi G,Gómez S,Tueros I,Bald C,Rodríguez VM,Martínez JA,Portillo MP

    更新日期:2009-12-01 00:00:00

  • Protein expression changed by nicotine in rat vascular smooth muscle cells.

    abstract::In order to observe the effects of nicotine on protein expression in rat vascular smooth muscle cells (SMCs), nicotine treated SMCs were studied by proteomic technologies combining two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF). Real-time RT-PCR was used to validate the differentially exp...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Wang Z,Wu W,Fang X,Wang Y,Xiao C,Zhao R,Wang L,Qiao Z

    更新日期:2007-06-01 00:00:00

  • Relationship between lipoprotein lipase and peroxisome proliferator-activated receptor-alpha expression in rat liver during development.

    abstract::The present study was addressed to determine whether the high expression of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in rat liver during the perinatal stage plays a role in the induction of liver lipoprotein lipase (LPL) expression and activity. Parallel increases in liver mRNA PPAR-alpha and LPL ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Panadero M,Bocos C,Herrera E

    更新日期:2006-09-01 00:00:00

  • Maternal and neonatal FTO rs9939609 polymorphism affect insulin sensitivity markers and lipoprotein profile at birth in appropriate-for-gestational-age term neonates.

    abstract::The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Gesteiro E,Sánchez-Muniz FJ,Ortega-Azorín C,Guillén M,Corella D,Bastida S

    更新日期:2016-06-01 00:00:00

  • Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice.

    abstract::The effect of long-lasting in vivo restriction of nitric oxide (NO) bioavailability on cardiac and renal P-type ATPases critical for intracellular ion homeostasis is controversial. Previous work has shown in eNOS knockout (eNOS(-/-)) mice hearts that Na(+)/K(+)- and Ca(2+)-ATPase activities were depressed but the unde...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Rezende DC,Pôças ES,Muzi-Filho H,Cunha VM,Caricati-Neto A,Jurkiewicz A,Noël F,Quintas LE

    更新日期:2013-06-01 00:00:00

  • Effects of overexpression of growth hormone on T cell activity in transgenic mice.

    abstract::Growth hormone plays a key role in the maturation and maintenance of the immune response, however, the effects of chronic high circulating concentrations of the hormone on the immune system is poorly understood. Transgenic mice overexpressing bovine growth hormone (b-GH) gene, fused to the rat phosphoenolpyruvate carb...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Esquifino AI,Arce A,Alvarez MP,Szary A,Brown-Borg H,Bartke A

    更新日期:2002-09-01 00:00:00

  • Expression of mRNA for glucose transport proteins in jejunum, liver, kidney and skeletal muscle of pigs.

    abstract::Although pigs are adapted to starch-rich diets and have high turnover rates of glucose, very scarce information is available on the molecular basis of glucose transport. Therefore, the present study attempted a systematic screening for the presence of mRNA of glucose transport proteins in main organs of glucose absorp...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Aschenbach JR,Steglich K,Gäbel G,Honscha KU

    更新日期:2009-09-01 00:00:00

  • Cardioprotective effect of linseed oil against isoproterenol-induced myocardial infarction in Wistar rats: a biochemical and electrocardiographic study.

    abstract::The present study was designed to evaluate the cardioprotective effect of Tunisian flaxseed oil (Linum usitatissimum) against isoproterenol-induced myocardial infarction in rats by studying hypertensive and cardiac damage markers especially electrocardiographic changes and troponin T serum level. In vitro, the extract...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章


    authors: Derbali A,Mnafgui K,Affes M,Derbali F,Hajji R,Gharsallah N,Allouche N,El Feki A

    更新日期:2015-06-01 00:00:00