Influence of chronic ethanol consumption on the muscarinic cholinergic control of rat pancreatic acinar cells.

Abstract:

:There are a number of hypothetical explanations for the actions of ethanol on the exocrine pancreas; among them, the cholinergic hypothesis has received special attention. According to this hypothesis, chronic alcohol consumption induces alterations in the control of exocrine pancreatic function resulting in cholinergic hyperstimulation of pancreatic acinar cells and their muscarinic receptors. Our aim was to investigate the cholinergic control of pancreatic enzyme secretion and the number and affinity of muscarinic receptors in the pancreatic acinar cells of rats subjected to chronic ethanol ingestion. We also investigated whether a high-fibre diet modifies the actions of ethanol on these aspects of the exocrine pancreatic function. Four groups of rats received either a standard or a high fibre diet, and either water or 20% (v/v) ethanol. After 6 months of treatment, isolated pancreatic acini were used for the determination of carbachol-stimulated amylase secretion and for the analysis of muscarinic receptors, using 1-[N-methyl-3H]scopolamine as a radioligand. Neither chronic ethanol intake nor a high fibre diet caused any apparent alteration in pancreatic histology, neither did them modify plasmatic amylase levels. Chronic alcoholization resulted in a significant increase in the amylase released from pancreatic acini in response to carbachol stimulation, but it did not affect either the number or the affinity of pancreatic acinar muscarinic receptors. The actions of ethanol are not significantly modified by the simultaneous consumption of a high fibre diet.

journal_name

J Physiol Biochem

authors

Acosta JJ,San Román JI,López MA,Calvo JJ

doi

10.1007/BF03179781

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

145-54

issue

3

eissn

1138-7548

issn

1877-8755

journal_volume

56

pub_type

杂志文章
  • Carnitine worsens both injury and recovery of contractile function after transient ischemia in perfused rat heart.

    abstract::While carnitine overload appears to have therapeutic effects in pathological situations such as heart recovery after ischemia, its benefits as dietary supplementation for aerobic exercise have been questioned. We studied the effect of carnitine supplementation on the response of perfused rat heart to ischemia and repe...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03168229

    authors: Díaz R,Lorita J,Soley M,Ramírez I

    更新日期:2008-03-01 00:00:00

  • Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey.

    abstract::Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathin...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-020-00761-1

    authors: López-González MV,González-García M,Peinado-Aragonés CA,Barbancho MÁ,Díaz-Casares A,Dawid-Milner MS

    更新日期:2020-11-01 00:00:00

  • Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats.

    abstract::Regular physical exercise is recognized as a nonpharmacological therapeutic strategy in the treatment of metabolic syndrome, and has been proposed for improving obesity, diabetic status, insulin resistance, and immune response. The aim of the present study was to evaluate the effect of a regular exercise program (trea...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-012-0196-5

    authors: Martín-Cordero L,García JJ,Hinchado MD,Bote E,Ortega E

    更新日期:2013-03-01 00:00:00

  • Protein expression changed by nicotine in rat vascular smooth muscle cells.

    abstract::In order to observe the effects of nicotine on protein expression in rat vascular smooth muscle cells (SMCs), nicotine treated SMCs were studied by proteomic technologies combining two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF). Real-time RT-PCR was used to validate the differentially exp...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03168227

    authors: Wang Z,Wu W,Fang X,Wang Y,Xiao C,Zhao R,Wang L,Qiao Z

    更新日期:2007-06-01 00:00:00

  • Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats.

    abstract::Chronic renal disease is characterized by the accumulation of extracellular matrix proteins in the kidney and a loss of renal function. Tubulointerstitial fibrosis has been reported to play an important role in the progression of chronic renal diseases. Transforming growth factor-beta1 (TGF-beta1) is a profibrotic cyt...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03168452

    authors: Prieto M,Rodríguez-Peña AB,Düwel A,Rivas JV,Docherty N,Pérez-Barriocanal F,Arévalo M,Vary CP,Bernabeu C,López-Novoa JM,Eleno N

    更新日期:2005-09-01 00:00:00

  • Does nitric oxide play a role in maternal tolerance towards the foetus?

    abstract::In pregnancy there occurs maternal tolerance to the foetus. Several mechanisms have been proposed to explain this phenomenon. The main immune population in the decidua are macrophages and natural killer cells, but with some "special" suppressor characteristics. There is also a predominant TH2 response. The non classic...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1007/BF03167033

    authors: González A,López AS,Alegre E,Alcázar JL,López-Moratalla N

    更新日期:2004-09-01 00:00:00

  • Gene methylation parallelisms between peripheral blood cells and oral mucosa samples in relation to overweight.

    abstract::Epigenetics has an important role in the regulation of metabolic adaptation to environmental modifications. In this sense, the determination of epigenetic changes in non-invasive samples during the development of metabolic diseases could play an important role in the procedures in primary healthcare practice. To help ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-017-0560-6

    authors: San-Cristobal R,Navas-Carretero S,Milagro FI,Riezu-Boj JI,Guruceaga E,Celis-Morales C,Livingstone KM,Brennan L,Lovegrove JA,Daniel H,Saris WH,Traczyk I,Manios Y,Gibney ER,Gibney MJ,Mathers JC,Martinez JA

    更新日期:2016-08-01 00:00:00

  • Effects of raloxifene and estradiol on bone turnover parameters in intact and ovariectomized rats.

    abstract::This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradio...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-010-0008-8

    authors: Canpolat S,Tug N,Seyran AD,Kumru S,Yilmaz B

    更新日期:2010-03-01 00:00:00

  • Maternal and neonatal FTO rs9939609 polymorphism affect insulin sensitivity markers and lipoprotein profile at birth in appropriate-for-gestational-age term neonates.

    abstract::The influence of maternal fat mass and obesity (FTO) gene polymorphism on neonatal insulin sensitivity/resistance biomarkers and lipoprotein profile has not been tested. The study aimed to assess the association between the FTO rs9939609 polymorphism in mother-neonate couples and neonatal anthropometrical measurements...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-016-0467-7

    authors: Gesteiro E,Sánchez-Muniz FJ,Ortega-Azorín C,Guillén M,Corella D,Bastida S

    更新日期:2016-06-01 00:00:00

  • Effect of nitrate and L-arginine therapy on nitric oxide levels in serum, heart, and aorta of fetal hypothyroid rats.

    abstract::Reduced nitric oxide availability and a heterogeneous pattern of nitric oxide synthase activity in some tissues have been reported in hypothyroidism. This study aimed at determining the effects of oral nitrate and L-arginine administration on serum, heart, and aorta nitric oxide metabolite concentrations in fetal hypo...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-013-0251-x

    authors: Ghasemi A,Mehrazin F,Zahediasl S

    更新日期:2013-12-01 00:00:00

  • Glycemia and insulinemia evaluation after high-sucrose and high-fat diets in lean and overweight/obese women.

    abstract::The study investigates the effect of weight-maintaining high-sucrose (HSD) and high-fat (HFD) diets on plasma glucose and insulin concentrations in lean and obese women, and verifies the correlation between insulin profile and body composition. Lean (G1 group, n=6, BMI= 21.4 (20.2-22.8) kg/m2) and overweight/obese (G2...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03168238

    authors: Volp AC,Hermsdorff HH,Bressan J

    更新日期:2008-06-01 00:00:00

  • Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes.

    abstract::Vitamin A or retinol plays a major role in the regulation of cellular homeostasis. Retinyl palmitate remains the main chemical form of vitamin A storage and is mainly located in hepatic stellate cells (HSCs) in lipid droplets resembling those found in adipose cells. White adipose tissue (WAT), is essentially involved ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1007/s13105-011-0101-7

    authors: Sauvant P,Cansell M,Atgié C

    更新日期:2011-09-01 00:00:00

  • Effects of overexpression of growth hormone on T cell activity in transgenic mice.

    abstract::Growth hormone plays a key role in the maturation and maintenance of the immune response, however, the effects of chronic high circulating concentrations of the hormone on the immune system is poorly understood. Transgenic mice overexpressing bovine growth hormone (b-GH) gene, fused to the rat phosphoenolpyruvate carb...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03179853

    authors: Esquifino AI,Arce A,Alvarez MP,Szary A,Brown-Borg H,Bartke A

    更新日期:2002-09-01 00:00:00

  • Hypophagia and induction of serotonin transporter gene expression in raphe nuclei of male and female rats after short-term fluoxetine treatment.

    abstract::Serotonin (5-HT) is one of the regulators of feeding in humans. Drugs acting on the serotoninergic system are used to treat bulimia nervosa and to enhance the effect of hypocaloric diets in overweight subjects. They act rapidly to normalise feeding when used to treat eating-related problems. To explore the role of the...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-012-0188-5

    authors: Lauzurica N,García-García L,Fuentes JA,Delgado M

    更新日期:2013-03-01 00:00:00

  • Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet.

    abstract::Recently resveratrol, a compound naturally occurring in various plants, has been proposed as a potential anti-obesity compound. The aim of the present work was to analyse the effects of different doses of resveratrol on body fat and serum parameters in rats. Thirty-two male Sprague-Dawley rats were randomly divided in...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03185932

    authors: Macarulla MT,Alberdi G,Gómez S,Tueros I,Bald C,Rodríguez VM,Martínez JA,Portillo MP

    更新日期:2009-12-01 00:00:00

  • S-resistin, a non secretable resistin isoform, impairs the insulin signalling pathway in 3T3-L1 adipocytes.

    abstract::S-resistin is a non-secretable resistin spliced variant, which is expressed mainly in the white adipose tissue from Wistar rats. Previous results confirmed that 3T3-L1 cells expressing s-resistin (3T3-L1-s-res) showed an inflammatory response and exhibited a decrease in glucose transport, both basal and insulin-stimul...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-015-0418-8

    authors: Rodríguez M,Moltó E,Aguado L,Gallardo N,Andrés A,Arribas C

    更新日期:2015-09-01 00:00:00

  • Double-stranded Let-7 mimics, potential candidates for cancer gene therapy.

    abstract::MicroRNAs (miRNAs), a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The ability of one single miRNA regulating multiple functionally related mRNAs makes it a new potential candidate for cancer gene therapy. Let-7s miRNAs have been demonstrated as tumor-supp...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-011-0124-0

    authors: Wang QZ,Lv YH,Gong YH,Li ZF,Xu W,Diao Y,Xu R

    更新日期:2012-03-01 00:00:00

  • Impact of adipokines and myokines on fat browning.

    abstract::Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1007/s13105-020-00736-2

    authors: Rodríguez A,Catalán V,Ramírez B,Unamuno X,Portincasa P,Gómez-Ambrosi J,Frühbeck G,Becerril S

    更新日期:2020-05-01 00:00:00

  • Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium.

    abstract::The weight loss observed in consumers of extracts of Citrus aurantium (bitter orange) has been tentatively attributed to the lipolytic and thermogenic effects of the alkaloids abundant in the unripe fruit. Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus me...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-011-0078-2

    authors: Mercader J,Wanecq E,Chen J,Carpéné C

    更新日期:2011-09-01 00:00:00

  • Nanocurcumin accords protection against acute hypobaric hypoxia induced lung injury in rats.

    abstract::Decline in oxygen availability experienced under hypobaric hypoxia (HH) mediates imbalance in lung fluid clearance and is a causative agent of acute lung injury. Here, we investigate the pathological events behind acute HH mediated lung injury and assess the therapeutic efficacy of nanocurcumin in its amelioration. We...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-016-0515-3

    authors: Nehra S,Bhardwaj V,Bansal A,Saraswat D

    更新日期:2016-12-01 00:00:00

  • Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats.

    abstract::Pouteria campechiana (Kunth) Baehni. is used as a remedy for coronary trouble, liver disorders, epilepsy, skin disease, and ulcer. Therefore, the present study aims to investigate the antioxidant and hepatoprotective effect of polyphenolic-rich P. campechiana fruit extract against acetaminophen-intoxicated rats. Total...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-013-0274-3

    authors: Aseervatham GS,Sivasudha T,Sasikumar JM,Christabel PH,Jeyadevi R,Ananth DA

    更新日期:2014-03-01 00:00:00

  • Production of healthier goat milk. Use of a concentrate supplemented with a "protected" fat rich in PUFA.

    abstract::In order to obtain healthier goat milk as far as its fat composition is concerned, milk production and composition trials were carried out with Granadina goats kept in semi-extensive breeding conditions. The animals were feeding indoors with a concentrate supplemented or not with 7% of fat conveniently protected again...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03179791

    authors: Sanz Sampelayo MR,Martín Alonso JJ,Morón D,Pérez L,Boza J

    更新日期:2000-09-01 00:00:00

  • Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes.

    abstract::Adiponectin, a hormone produced by adipocytes, is involved in glucose metabolism and insulin sensitivity. The production of this adipokine is impaired in obesity and insulin resistance. Eicosapentaenoic acid (EPA) is a dietary n-3 polyunsaturated fatty acid that improves insulin sensitivity in several models of obesit...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/BF03174067

    authors: Lorente-Cebrián S,Pérez-Matute P,Martínez JA,Marti A,Moreno-Aliaga MJ

    更新日期:2006-06-01 00:00:00

  • Age-related regulation of excitation-contraction coupling in rat heart.

    abstract::Hearts from subjects with different ages have different Ca(2+) signaling. Release of Ca(2+) from intracellular stores in response to an action potential initiates cardiac contraction. Both depolarization-stimulated and spontaneous Ca(2+) releases, Ca(2+) transients and Ca(2+) sparks, demonstrate the main events of exc...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-011-0077-3

    authors: Kandilci HB,Tuncay E,Zeydanli EN,Sozmen NN,Turan B

    更新日期:2011-09-01 00:00:00

  • Liver histone H3 methylation and acetylation may associate with type 2 diabetes development.

    abstract::Type 2 diabetes (T2D) is a complicated systemic disease, and the exact pathogenetic molecular mechanism is unclear. Distinct histone modifications regulate gene expression in certain diseases, but little is known about histone epigenetics in diabetes. In the current study, C57BL/6 J mice were used to build T2D model, ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-015-0385-0

    authors: Tu P,Li X,Ma B,Duan H,Zhang Y,Wu R,Ni Z,Jiang P,Wang H,Li M,Zhu J,Li M

    更新日期:2015-03-01 00:00:00

  • Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats.

    abstract::Thrombospondin 1 (TSP-1), an antiangiogenic factor and transforming growth factor (TGF)-β activity regulator, has been recently recognized as an adipokine that correlates with obesity, inflammation and insulin resistance processes. In the present study, epididymal adipocytes of rats that were fed a chow or a high-fat ...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-011-0081-7

    authors: Garcia-Diaz DF,Arellano AV,Milagro FI,Moreno-Aliaga MJ,Portillo MP,Martinez JA,Campion J

    更新日期:2011-09-01 00:00:00

  • Hypothermia can reverse hepatic oxidative stress damage induced by hypoxia in rats.

    abstract::Our previous findings demonstrated that hypothermia enhances the reduction potential in the liver and helps to maintain the plasmatic antioxidant pool. Here, we aimed to elucidate if hypothermia protects against hypoxia-induced oxidative stress damage in rat liver. Several hepatic markers of oxidative stress were comp...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-016-0500-x

    authors: Garnacho-Castaño MV,Alva N,Sánchez-Nuño S,Bardallo RG,Palomeque J,Carbonell T

    更新日期:2016-12-01 00:00:00

  • Protective effect of rosmarinic acid against oxidative stress biomarkers in liver and kidney of strepotozotocin-induced diabetic rats.

    abstract::In the present study, we investigated the efficiency of rosmarinic acid (RA) in preventing the alteration of oxidative parameters in the liver and kidney of diabetic rats induced by streptozotocin (STZ). The animals were divided into six groups (n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol, and di...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-015-0438-4

    authors: Mushtaq N,Schmatz R,Ahmed M,Pereira LB,da Costa P,Reichert KP,Dalenogare D,Pelinson LP,Vieira JM,Stefanello N,de Oliveira LS,Mulinacci N,Bellumori M,Morsch VM,Schetinger MR

    更新日期:2015-12-01 00:00:00

  • Glitazones inhibit human monoamine oxidase but their anti-inflammatory actions are not mediated by VAP-1/semicarbazide-sensitive amine oxidase inhibition.

    abstract::Glitazones are peroxisome proliferator-activated receptor gamma (PPARγ) agonists widely used as antidiabetic drugs also known as thiazolidinediones. Most of them exert other effects such as anti-inflammatory actions via mechanisms supposed to be independent from PPARγ activation (e.g., decreased plasma monocyte chemoa...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-014-0379-3

    authors: Carpéné C,Bizou M,Tréguer K,Hasnaoui M,Grès S

    更新日期:2015-09-01 00:00:00

  • Different vasoactive effects of chronic endothelial and neuronal NO-synthase inhibition in young Wistar rats.

    abstract::While the unequivocal pattern of endothelial nitric oxide synthase (eNOS) inhibition in cardiovascular control is recognized, the role of NO produced by neuronal NOS (nNOS) remains unclear. The aim of this study was to compare the effects of chronic treatment with 7-nitroindazole (7-NI, nNOS inhibitor) and N(G)-nitro-...

    journal_title:Journal of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1007/s13105-014-0343-2

    authors: Cacanyiova S,Berenyiova A,Malekova M,Kristek F,Dovinova I,Krenek P,Pivackova L,Pifkova I

    更新日期:2014-09-01 00:00:00