Abstract:
:Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet. This review mainly focuses on interconnecting role of PGC-1 α and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition.
journal_name
J Physiol Biochemjournal_title
Journal of physiology and biochemistryauthors
Thirupathi A,de Souza CTdoi
10.1007/s13105-017-0576-ysubject
Has Abstractpub_date
2017-11-01 00:00:00pages
487-494issue
4eissn
1138-7548issn
1877-8755pii
10.1007/s13105-017-0576-yjournal_volume
73pub_type
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