Characterization of a novel large-field cone bipolar cell type in the primate retina: evidence for selective cone connections.

Abstract:

:Parallel processing of visual information begins at the first synapse in the retina between the photoreceptors and bipolar cells. Ten bipolar cell types have been previously described in the primate retina: one rod and nine cone bipolar types. In this paper, we describe an 11th type of bipolar cell identified in Golgi-stained macaque retinal whole mount and vertical section. Axonal stratification depth, in addition to dendritic and axonal morphology, distinguished the "giant" cell from all previously well-recognized bipolar cell types. The giant bipolar cell had a very large and sparsely branched dendritic tree and a relatively large axonal arbor that costratified with the DB4 bipolar cell near the center of the inner plexiform layer. The sparseness of the giant bipolar's dendritic arbor indicates that, like the blue cone bipolar, it does not contact all the cones in its dendritic field. Giant cells contacting the same cones as midget bipolar cells, which are known to contact single long-wavelength (L) or medium-wavelength (M) cones, demonstrate that the giant cell does not exclusively contact short-wavelength (S) cones and, therefore, is not a variant of the previously described blue cone bipolar. This conclusion is further supported by measurement of the cone contact spacing for the giant bipolar. The giant cell contacts an average of about half the cones in its dendritic field (mean ± S.D. = 52 ± 17.6%; n = 6), with a range of 27-82%. The dendrites from single or neighboring giant cells that converge onto the same cones suggest that the giant cell may selectively target a subset of cones with a highly variable local density, such as the L or M cones.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Joo HR,Peterson BB,Haun TJ,Dacey DM

doi

10.1017/S0952523810000374

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

29-37

issue

1

eissn

0952-5238

issn

1469-8714

pii

S0952523810000374

journal_volume

28

pub_type

杂志文章
  • Monocular mechanisms determine plaid motion coherence.

    abstract::Although the neural location of the plaid motion coherence process is not precisely known, the middle temporal (MT) cortical area has been proposed as a likely candidate. This claim rests largely on the neurophysiological findings showing that in response to plaid stimuli, a subgroup of cells in area MT responds to th...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380000852x

    authors: Alais D,van der Smagt MJ,Verstraten FA,van de Grind WA

    更新日期:1996-07-01 00:00:00

  • Development of multibank rod retinae in deep-sea fishes.

    abstract::We studied the development of multibank rod retinae by monitoring the size-related addition of new layers of rod inner and outer segments in four species of deep-sea fishes and found two different growth paradigms. In the mesopelagic Chauliodus sloani, new banks of rod inner and outer segments are added as long as the...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252389815304x

    authors: Fröhlich E,Wagner HJ

    更新日期:1998-05-01 00:00:00

  • Histochemical localization of acetylcholinesterase in the lateral eye and brain of Limulus polyphemus: might acetylcholine be a neurotransmitter for lateral inhibition in the lateral eye?

    abstract::The distribution of acetylcholinesterase (AChE) in the lateral eye and brain of the horseshoe crab was investigated with histochemical means using standard controls to eliminate butyrylcholinesterase and nonspecific staining. Intense staining was observed in the neural plexus of the lateral compound eye, in the latera...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800003928

    authors: Hornstein EP,Sambursky DL,Chamberlain SC

    更新日期:1994-09-01 00:00:00

  • AMPA-selective glutamate receptor subunits GluR2 and GluR4 in the cat retina: an immunocytochemical study.

    abstract::AMPA-selective glutamate receptors play a major role in glutamatergic neurotransmission in the retina and are expressed in a variety of neuronal subpopulations. In the present study, immunocytochemical techniques were used to visualize the distribution of GluR2 and GluR4 subunits in the cat retina. Results were compar...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899166100

    authors: Qin P,Pourcho RG

    更新日期:1999-11-01 00:00:00

  • The functional organization of area V2, I: specialization across stripes and layers.

    abstract::We used qualitative tests to assess the sensitivity of 1043 V2 neurons (predominantly multiunits) in anesthetised macaque monkeys to direction, length, orientation, and color of moving bar stimuli. Spectral sensitivity was additionally tested by noting ON or OFF responses to flashed stimuli of varied size and color. T...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523802191164

    authors: Shipp S,Zeki S

    更新日期:2002-03-01 00:00:00

  • Two opposite effects of ATP on the apparent sensitivity of the cGMP-gated channel of the carp retinal cone.

    abstract::Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in 33%. ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed si...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800012578

    authors: Watanabe S,Shen J

    更新日期:1997-07-01 00:00:00

  • Large retinal ganglion cells in the pipid frog Xenopus laevis form independent, regular mosaics resembling those of teleost fishes.

    abstract::Population-based studies of retinal neurons have helped to reveal their natural types in mammals and teleost fishes. In this, the first such study in a frog, labeled ganglion cells of the mesobatrachian Xenopus laevis were examined in flatmounts. Cells with large somata and thick dendrites could be divided into three ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380001155x

    authors: Shamim KM,Tóth P,Cook JE

    更新日期:1997-09-01 00:00:00

  • A neural model of foveal light adaptation and afterimage formation.

    abstract::Psychophysical research has documented the existence of three processes in light adaptation: a fast subtractive process, a divisive process that is fast at light onset and slower at light offset, and a very slow subtractive process (Hayhoe et al., 1987). In the neural model developed here, the fast subtractive process...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/s0952523800012098

    authors: Wilson HR

    更新日期:1997-05-01 00:00:00

  • Absolute and relative sensitivity of the scotopic system of rat: electroretinography and behavior.

    abstract::The goal of the present study was to relate the dark and light-adapted flash sensitivity of the scotopic threshold response (STR) and rod b-wave of the electroretinogram (ERG) to behaviorally measured rod increment threshold responses. Small amplitudes of the dark-adapted STR and b-wave, the latter after application o...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523801184142

    authors: Naarendorp F,Sato Y,Cajdric A,Hubbard NP

    更新日期:2001-07-01 00:00:00

  • Movement of retinal along cone and rod photoreceptors.

    abstract::Single isolated photoreceptors can be taken through a visual cycle of light adaptation by bleaching visual pigment, followed by dark adaptation when supplied with 11-cis retinal. Light adaptation after bleaching is manifested by faster response kinetics and a permanent reduction in sensitivity to light flashes, presum...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800001735

    authors: Jin J,Jones GJ,Cornwall MC

    更新日期:1994-03-01 00:00:00

  • Development of the rabbit retina, III: Differential retinal growth, and density of projection neurons and interneurons.

    abstract::To provide a quantitative description of postnatal retinal expansion in rabbits, a new procedure was developed to map the retinae, which cover the inner surface of hemispheres or parts of rotation ellipsoids, in situ, onto a single plane. This method, as well as the known distribution of Müller cells per unit retinal ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004703

    authors: Reichenbach A,Schnitzer J,Reichelt E,Osborne NN,Fritzsche B,Puls A,Richter U,Friedrich A,Knothe AK,Schober W

    更新日期:1993-05-01 00:00:00

  • Visual callosal projections in the adult ferret.

    abstract::The laminar and tangential organization of visual callosal projections of areas 17 and 18 were investigated in the adult ferret, using histochemical methods to visualize axonally transported horseradish peroxidase (HRP). Normal adult ferrets were given injections of HRP throughout one visual cortex or had gelfoam soak...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006398

    authors: Grigonis AM,Rayos del Sol-Padua RB,Murphy EH

    更新日期:1992-07-01 00:00:00

  • Interlaminar connections of the superior colliculus in the tree shrew. II: Projections from the superficial gray to the optic layer.

    abstract::This study of the tree shrew, Tupaia belangeri, provides evidence for an intracollicular pathway that arises in the superficial gray layer and terminates in the optic layer. As a first step, Nissl, myelin, and cytochrome oxidase stains were used to identify the layers of the superior colliculus in the tree shrew. Seco...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008464

    authors: Lee P,Hall WC

    更新日期:1995-05-01 00:00:00

  • Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.

    abstract::During adaptation to an increase in environmental luminance, retinal signaling adjustments are mediated by the neuromodulator dopamine. Retinal dopamine is released with light and can affect center-surround receptive fields, the coupling state between neurons, and inhibitory pathways through inhibitory receptors and n...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523819000129

    authors: Mazade RE,Eggers ED

    更新日期:2020-02-12 00:00:00

  • Effects of different forms of monocular deprivation on primary visual cortex maps.

    abstract::Monocular deprivation (MD) by lid suture is one of the classic paradigms for the study of developmental plasticity in the cerebral cortex, and we have detailed knowledge of its anatomical and physiological consequences as well as underlying molecular and cellular mechanisms. However, the effects of other forms of mani...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523812000260

    authors: Jaffer S,Vorobyov V,Sengpiel F

    更新日期:2012-09-01 00:00:00

  • Development of sensitivity to visual motion in macaque monkeys.

    abstract::The development of spatial vision is relatively well documented in human and nonhuman primates. However, little is known about the development of sensitivity to motion. We measured the development of sensitivity to direction of motion, and the relationship between motion and contrast sensitivity in macaque monkeys as ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523804216054

    authors: Kiorpes L,Movshon JA

    更新日期:2004-11-01 00:00:00

  • Pharmacological inactivation of pretectal nuclei reveals different modulatory effects on retino-geniculate transmission by X and Y cells in the cat.

    abstract::The modulatory influence of pretectal neurons on retino-geniculate transmission in the cat was studied by cross-correlation analysis of single-unit activity simultaneously recorded from the dorsal lateral geniculate nucleus (dLGN) and the pretectum (PT) and with reversible inactivation of the PT by GABA microiontophor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800007288

    authors: Funke K,Eysel UT

    更新日期:1995-01-01 00:00:00

  • Topographic analysis of the ganglion cell layer in the retina of the four-eyed fish Anableps anableps.

    abstract::Fish of the genus Anableps (Anablepidae, Cyprinodontiformes) have eyes that are adapted for simultaneous aerial and aquatic vision. In this study we investigate some of the corresponding retinal specializations of the adult Anableps anableps eye using retinal transverse sections and wholemounts. The linear dimensions ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806230232

    authors: Oliveira FG,Coimbra JP,Yamada ES,Montag LF,Nascimento FL,Oliveira VA,da Mota DL,Bittencourt AM,da Silva VL,da Costa BL

    更新日期:2006-11-01 00:00:00

  • Peripheral shift reduces visual sensitivity in cat geniculate neurones.

    abstract::The sudden displacement of the retinal image during a saccade raises the visual threshold of human observers to foveal stimuli. The fall in visual sensitivity observed during this phenomenon, known as saccadic suppression, seems to occur very early in the visual processing chain. The lateral geniculate nucleus (LGN) i...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523898155128

    authors: Derrington AM,Felisberti F

    更新日期:1998-09-01 00:00:00

  • Contrast discrimination: a model and a hypothesis concerning the role of cholinergic modulation in contrast perception.

    abstract::A model of contrast discrimination performance in human observers is developed and then extended to cover effects on performance of anticholinergic drugs. It is shown that it is necessary to assume that neural noise increases at high spatial frequencies in order to provide a satisfactory model of variations in discrim...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800009123

    authors: Smith AT

    更新日期:1996-09-01 00:00:00

  • Regenerating axons from adult chick retinal ganglion cells recognize topographic cues from embryonic central targets.

    abstract::We investigated whether regenerating mature axons recapitulate embryonic features essential to successful reconnectivity within the injured nervous system. Strips from embryonic and adult chick retinae were cultured, and outgrowing axons were examined morphometrically and immunohistochemically. In addition, the target...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800002558

    authors: Vanselow J,Müller B,Thanos S

    更新日期:1991-06-01 00:00:00

  • VEP and PERG acuity in anesthetized young adult rhesus monkeys.

    abstract::This study used the swept spatial-frequency method to compare retinal and cortical acuity in anesthetized young adult rhesus monkeys. Visual evoked potentials (VEPs) and pattern electroretinographic responses (PERGs) were recorded from 25 monkeys (age range: 4-12 years) anesthetized with a continuous infusion of propo...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899164010

    authors: Ver Hoeve JN,Danilov YP,Kim CB,Spear PD

    更新日期:1999-07-01 00:00:00

  • Intact "biological motion" and "structure from motion" perception in a patient with impaired motion mechanisms: a case study.

    abstract::A series of psychophysical tests examining early and later aspects of image-motion processing were conducted in a patient with bilateral lesions involving the posterior visual pathways, affecting the lateral parietal-temporal-occipital cortex and the underlying white matter (as shown by magnetic resonance imaging stud...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800000444

    authors: Vaina LM,Lemay M,Bienfang DC,Choi AY,Nakayama K

    更新日期:1990-10-01 00:00:00

  • Spatio-temporal characterization of retinal opsin gene expression during thyroid hormone-induced and natural development of rainbow trout.

    abstract::The abundance and spatial distribution of retinal cone photoreceptors change during thyroid hormone (TH)-induced and natural development of rainbow trout (Oncorhynchus mykiss). These changes are thought to allow the fish to adapt to different photic environments throughout its life history. To date, the ontogeny of ra...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806232139

    authors: Veldhoen K,Allison WT,Veldhoen N,Anholt BR,Helbing CC,Hawryshyn CW

    更新日期:2006-03-01 00:00:00

  • A phenomenological model of visually evoked spike trains in cat geniculate nonlagged X-cells.

    abstract::The visual information that first-order cortical cells receive is contained in the visually evoked spike trains of geniculate relay cells. To address functional issues such as the ON/OFF structure of visual cortical receptive fields with modelling studies, a geniculate cell model is needed where the spatial and tempor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523898156158

    authors: Gazères N,Borg-Graham LJ,Frégnac Y

    更新日期:1998-11-01 00:00:00

  • Contrast processing by ON and OFF bipolar cells.

    abstract::Much of what is currently known about the visual response of retinal bipolar cells is based on studies of rod-dominant responses to flashes in the dark in the isolated retina. This minireview summarizes quantitative findings on contrast processing in the intact light-adapted retina based on intracellular recording fro...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/S0952523810000313

    authors: Burkhardt DA

    更新日期:2011-01-01 00:00:00

  • Space-time spectra of complex cell filters in the macaque monkey: a comparison of results obtained with pseudowhite noise and grating stimuli.

    abstract::White noise stimuli were used to estimate second-order kernels for complex cells in cortical area V1 of the macaque monkey, and drifting grating stimuli were presented to the sample of neurons to obtain orientation and spatial-frequency tuning curves. Using these data, we quantified how well second-order kernels predi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800003102

    authors: Gaska JP,Jacobson LD,Chen HW,Pollen DA

    更新日期:1994-07-01 00:00:00

  • Mechanisms of early visual processing in the medulla of the locust optic lobe: how self-inhibition, spatial-pooling, and signal rectification contribute to the properties of transient cells.

    abstract::In the arthropod medulla, which is the second ganglion on the afferent visual pathway, a column of about 40 cells represents each point in space (i.e. compound eye facet). Some stages of visual processing underlying the responses of one class of cells in the locust medulla have been identified. These transient cells g...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800004831

    authors: Osorio D

    更新日期:1991-10-01 00:00:00

  • The morphology of the dorsal eye of the hydrothermal vent shrimp, Rimicaris exoculata.

    abstract::The bresiliid shrimp, Rimicaris exoculata, lives in large masses on the sides of hydrothermal vent chimneys at two sites on the Mid-Atlantic Ridge. Although essentially no daylight penetrates to depths of 3500 m, very dim light is emitted from the hydrothermal vents themselves. To exploit this light, R. exoculata has ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800009421

    authors: O'Neill PJ,Jinks RN,Herzog ED,Battelle BA,Kass L,Renninger GH,Chamberlain SC

    更新日期:1995-09-01 00:00:00

  • Mapping photoreceptor and postreceptoral labelling patterns using a channel permeable probe (agmatine) during development in the normal and RCS rat retina.

    abstract::The aim of this study was to determine whether agmatine, a channel permeable probe, can identify photoreceptor dysfunction in the Royal College of Surgeons (RCS) retina at an earlier stage to that shown by apoptosis or anatomical markers, and also characterize the neurochemical development of the inner retina in the n...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523801191066

    authors: Kalloniatis M,Tomisich G,Wellard JW,Foster LE

    更新日期:2002-01-01 00:00:00