Abstract:
:We have investigated sensillum development in Drosophila embryos homozygous for mutations in the locus string (stg). In these embryos, cell division is blocked following blastoderm formation. This permits a study of the differentiative fate of undivided precursor cells, in particular those giving rise to the larval sensory organs (sensilla). Of the different cell fates normally represented in the sensilla (i.e., sensory neuron, thecogen cell, trichogen cell, tormogen cell, glia cell), only the phenotype of sensory neurons is expressed morphologically in stg embryos, suggesting that the neuronal fate predominates over the fates of the nonneuronal accessory cells. Consistent with this finding, the P element-lacZ insertion A1-2nd-29, which is a marker for trichogen and tormogen cells in the wild-type embryo, is not expressed in the body wall of the stg embryo. Some sensillum precursor cells appear to express a mixed fate in stg mutants: They express antigens (recognized by the monoclonal antibodies 22C10 and 21A6) which in the wild-type appear in separate cells (sensory neurons and thecogen cell, respectively). The differentiation of undivided cells in stg embryos is not restricted to the peripheral nervous system; in all types of tissues analyzed in this study (e.g., epidermis, intestine, muscle, CNS), precursor cells express characteristics normally exhibited by their progeny.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Hartenstein V,Posakony JWdoi
10.1016/0012-1606(90)90184-ksubject
Has Abstractpub_date
1990-03-01 00:00:00pages
147-58issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(90)90184-Kjournal_volume
138pub_type
杂志文章abstract::Previous attempts to study sorting out of Drosophila imaginal disc cells have been hampered by an inability to thoroughly dissociate these cells and the need to use cuticular markers which require several days of in vivo culture. This study overcomes these limitations by using a new dissociation procedure and a geneti...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90049-1
更新日期:1985-04-01 00:00:00
abstract::Epithelial planar cell polarity (PCP) allows epithelial cells to coordinate their development to that of the tissue in which they reside. The mechanisms that impart PCP as well as effectors that execute the polarizing instructions are being sought in many tissues. We report that the epidermal epithelium of Drosophila ...
journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2006-09-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90086-9
更新日期:1989-07-01 00:00:00
abstract::Previous studies from this laboratory (M. Bronner-Fraser (1985). J. Cell Biol. 101, 610) have demonstrated that an antibody to a cell surface receptor complex caused alterations in avian neural crest cell migration. Here, these observations are extended to examine the distribution and persistency of injected antibody,...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90320-9
更新日期:1986-10-01 00:00:00
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journal_title:Developmental biology
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doi:10.1016/j.ydbio.2020.12.022
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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更新日期:1999-07-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2017.01.021
更新日期:2017-12-01 00:00:00
abstract::Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of w...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(02)00046-5
更新日期:2003-03-01 00:00:00
abstract::The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.12.005
更新日期:2010-02-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0254
更新日期:2001-06-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90066-0
更新日期:1983-05-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90277-x
更新日期:1984-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9271
更新日期:1999-06-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90075-e
更新日期:1991-02-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.08.017
更新日期:2015-10-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0096
更新日期:1996-04-10 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90092-4
更新日期:1989-07-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.07.017
更新日期:2013-10-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.0113
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1985-07-01 00:00:00
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更新日期:2017-12-15 00:00:00
abstract::cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90268-0
更新日期:1988-07-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2001-02-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2003.07.016
更新日期:2003-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8663
更新日期:1997-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9460
更新日期:1999-12-01 00:00:00
abstract:FOREWORD:The neural crest has been the main object of my investigations during my career in science, up to now. It is a fascinating topic for an embryologist because of its two unique characteristics: its large degree of multipotency and the fact that its development involves a phase during which its component cells mi...
journal_title:Developmental biology
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.05.500
更新日期:2010-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9894
更新日期:2000-12-01 00:00:00