β-Lactam and glycopeptide antibiotics: first and last line of defense?

abstract：:Here, we discuss recent advances in the development of artificial red blood cell (RBC) substitutes, illustrating lessons learned from initial attempts using perfluorocarbon (PFC) emulsions and acellular hemoglobin-based oxygen carriers (HBOCs). We also highlight novel oxygen-containing microparticles, nanoparticles, a...

journal_title：Trends in biotechnology

authors： Tao Z,Ghoroghchian PP

更新日期：2014-09-01 00:00:00

abstract：:Phytoremediation holds promise for in situ treatment of heavy metal contaminated soils. Recently, the benefits of combining siderophore-producing bacteria (SPB) with plants for metal removal from contaminated soils have been demonstrated. Metal-resistant SPB play an important role in the successful survival and growth...

journal_title：Trends in biotechnology

authors： Rajkumar M,Ae N,Prasad MN,Freitas H

更新日期：2010-03-01 00:00:00

abstract：:Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

journal_title：Trends in biotechnology

authors： Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

更新日期：2016-11-01 00:00:00

abstract：:Precise control of transgene expression is pivotal to the engineering of plants with increased disease resistance. Many early attempts to boost disease resistance used constitutive overexpression of defence components but frequently this resulted in poor quality plants. It is now clear that the extensive cellular repr...

journal_title：Trends in biotechnology

authors： Gurr SJ,Rushton PJ

更新日期：2005-06-01 00:00:00

abstract：:Neurodegenerative diseases are of major socioeconomic importance and represent an enormous challenge for the scientific and medical communities. Advances in molecular genetics during the past decade have begun to provide approaches for the establishment of animal models for these disorders using transgenic technology....

journal_title：Trends in biotechnology

authors： Theuring F,Thunecke M,Kosciessa U,Turner JD

更新日期：1997-08-01 00:00:00

abstract：:Bacteriorhodopsin (BR) is the photoactive proton pump found in the purple membrane of the salt marsh archaeon Halobacterium salinarum. Evolution has optimized this protein for high photochemical efficiency, thermal stability and cyclicity, as the organism must be able to function in a hot, stagnant and resource-limite...

journal_title：Trends in biotechnology

authors： Wise KJ,Gillespie NB,Stuart JA,Krebs MP,Birge RR

更新日期：2002-09-01 00:00:00

abstract：:Microbial contamination of polymer surfaces has become a significant challenge in domestic, industrial, and biomedical applications. Recent progress in our understanding of how topographical features of different length scales can be used to effectively and selectively control the attachment and proliferation of diffe...

journal_title：Trends in biotechnology

authors： Nguyen DHK,Bazaka O,Bazaka K,Crawford RJ,Ivanova EP

更新日期：2020-05-01 00:00:00

abstract：:There are many aims associated with the optimization of fermentation processes. Optimization is expected to increase the yield of the final product but the process must be compliant with good manufacturing practices, the available equipment and the expected final scale of operation. Dealing with genetically modified m...

journal_title：Trends in biotechnology

authors： Thiry M,Cingolani D

更新日期：2002-03-01 00:00:00

abstract：:Along with the development of metabolic engineering and synthetic biology tools, various microbes are being used to produce aromatic chemicals. In microbes, aromatics are mainly produced via a common important precursor, chorismate, in the shikimate pathway. Natural or non-natural aromatics have been produced by engin...

journal_title：Trends in biotechnology

authors： Noda S,Kondo A

更新日期：2017-08-01 00:00:00

abstract：:The genetic code is the manual that cells use to incorporate amino acids into proteins. It is possible to artificially expand this manual through cellular, molecular, and chemical manipulations to improve protein functionality. Strategies for in vivo genetic code expansion are under the same functional constraints as ...

journal_title：Trends in biotechnology

authors： Ros E,Torres AG,Ribas de Pouplana L

更新日期：2020-09-04 00:00:00

abstract：:Plant-based environmental remediation, or phytoremediation, has been widely pursued in recent years as a favorable clean-up technology and is an area of intensive scientific investigation. For the vast majority of field applications, vegetative 'phyto-crops' are selected specifically for their capacity for site decont...

journal_title：Trends in biotechnology

authors： Rugh CL

更新日期：2004-10-01 00:00:00

abstract：:The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both ele...

journal_title：Trends in biotechnology

authors： Fan C,Plaxco KW,Heeger AJ

更新日期：2005-04-01 00:00:00

abstract：:The availability of the human genome sequence has enabled the exploration and exploitation of the human genome and proteome to begin. Research has now focussed on the annotation of the genome and in particular of the proteome. With expert annotation extracted from the literature by biologists as the foundation, it has...

journal_title：Trends in biotechnology

authors： O'Donovan C,Apweiler R,Bairoch A

更新日期：2001-05-01 00:00:00

abstract：:The best long-term prospects for the reduction in the number of deaths due to cancer lie with screening and prevention rather than with therapy of the advanced disease. Screening efficiency will be improved by the identification of individuals at inherited high risk of cancer. Understanding the mechanism of predisposi...

journal_title：Trends in biotechnology

authors： Ponder BA

更新日期：1990-04-01 00:00:00

abstract：:Attempts through somatic cell nuclear transfer to expand wild populations that have shrunk to critical numbers is a logical extension of the successful cloning of mammals. However, although the first mammal was cloned 10 years ago, nuclear reprogramming remains phenomenological, with abnormal gene expression and epige...

journal_title：Trends in biotechnology

authors： Loi P,Galli C,Ptak G

更新日期：2007-05-01 00:00:00

abstract：:Adsorption in stable expanded beds enables proteins to be recovered directly from particulate-containing feedstocks, such as fermentation broths and preparations of disrupted cells, without the need for prior removal of the suspended solids, which would normally result in the blockage of packed beds. The adoption of t...

journal_title：Trends in biotechnology

authors： Chase HA

更新日期：1994-08-01 00:00:00

abstract：:Many organisms have the ability to form spores, a remarkable phase in their life cycles. Compared with vegetative cells, spores have several advantages (e.g. resistance to toxic compounds, temperature, desiccation and radiation) making them well suited to various applications. The applications of spores that first spr...

journal_title：Trends in biotechnology

authors： Wolken WA,Tramper J,van der Werf MJ

更新日期：2003-08-01 00:00:00

abstract：:Microbial exopolysaccharides such as xanthan and dextran have been commercial products for many years; the search for new gelling agents has yielded gellan. Exopolysaccharides have many other novel properties to offer, and the discovery of immune modulation and tumouristasis by beta-D-glucans, and the use of bacterial...

journal_title：Trends in biotechnology

authors： Sutherland IW

更新日期：1998-01-01 00:00:00

abstract：:The unicellular alga Dunaliella salina is the most interesting cell factory for the commercial production of beta-carotene because this species accumulates carotenoids to high concentrations. Nevertheless, little is known about the underlying mechanisms of carotenoid accumulation. Here, we review the regulatory mechan...

journal_title：Trends in biotechnology

authors： Lamers PP,Janssen M,De Vos RC,Bino RJ,Wijffels RH

更新日期：2008-11-01 00:00:00

abstract：:The global movement of people and goods has increased the risk of biosecurity threats and their potential to incur large economic, social, and environmental costs. Conventional manual biosecurity surveillance methods are limited by their scalability in space and time. This article focuses on autonomous surveillance sy...

journal_title：Trends in biotechnology

authors： Jurdak R,Elfes A,Kusy B,Tews A,Hu W,Hernandez E,Kottege N,Sikka P

更新日期：2015-04-01 00:00:00

abstract：:The tricarboxylic acid (TCA) cycle has been used for decades in the microbial production of chemicals such as citrate, L-glutamate, and succinate. Maximizing yield is key for cost-competitive production. However, for most TCA cycle products, the maximum pathway yield is lower than the theoretical maximum yield (Y(E))....

journal_title：Trends in biotechnology

authors： Vuoristo KS,Mars AE,Sanders JPM,Eggink G,Weusthuis RA

更新日期：2016-03-01 00:00:00

abstract：:Atherosclerosis and heart disease are still the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts but the patency of such grafts is limited compared to natural materials. Tissue engineering, whereby living tissue replacements can be co...

journal_title：Trends in biotechnology

authors： Sales KM,Salacinski HJ,Alobaid N,Mikhail M,Balakrishnan V,Seifalian AM

更新日期：2005-09-01 00:00:00

abstract：:Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biological potential, it w...

journal_title：Trends in biotechnology

authors： Sadowski MI,Grant C,Fell TS

更新日期：2016-03-01 00:00:00

abstract：:The ability to detect single-base changes is of fundamental importance in molecular genetics. This is particularly true in human genetics, where interest in linking mutations of identified genes to particular disease phenotypes is most intense, and where a demand exists for clinical diagnosis of defined mutations. In ...

journal_title：Trends in biotechnology

authors： Prosser J

更新日期：1993-06-01 00:00:00

abstract：:Microalgal production technologies are seen as increasingly attractive for bioenergy production to improve fuel security and reduce CO(2) emissions. Photosynthetically derived fuels are a renewable, potentially carbon-neutral and scalable alternative reserve. Microalgae have particular promise because they can be prod...

journal_title：Trends in biotechnology

authors： Larkum AW,Ross IL,Kruse O,Hankamer B

更新日期：2012-04-01 00:00:00

abstract：:Chronic diseases, particularly malignancies and immune-mediated inflammatory diseases (IMIDs), are a challenging frontier for clinical diagnosis and treatment, as well as for biomedical research. Current treatment regimens are frequently insufficient and thus new treatment strategies are needed. Novel therapies for di...

journal_title：Trends in biotechnology

authors： Tarner IH,Müller-Ladner U,Fathman CG

更新日期：2004-06-01 00:00:00

abstract：:Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma t...

journal_title：Trends in biotechnology

authors： Dai X,Bazaka K,Richard DJ,Thompson ERW,Ostrikov KK

更新日期：2018-11-01 00:00:00

abstract：:Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP®s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membran...

journal_title：Trends in biotechnology

authors： Wyatt LC,Lewis JS,Andreev OA,Reshetnyak YK,Engelman DM

更新日期：2017-07-01 00:00:00

abstract：:Two of the primary responses in a cell when perturbed are modulation of the dynamics of its constituent gene expression and protein abundance to restore steady-state homeostasis. To obtain a detailed model of the restoration of this balance, it is necessary to examine the kinetics of transcription and translation, thu...

journal_title：Trends in biotechnology

authors： Hughes C,Krijgsveld J

更新日期：2012-12-01 00:00:00

abstract：:Biosensor technology can offer the livestock industry new types of monitoring and measuring devices of which the specificity, sensitivity, reproducibility, speed and ease of use exceed the current technology. Biosensors can be applied to the detection and identification of infectious diseases in livestock, contaminant...

journal_title：Trends in biotechnology

authors： Velasco-Garcia MN,Mottram T

更新日期：2001-11-01 00:00:00