Prospects for genetic diagnosis of inherited predisposition to cancer.

abstract：:Room temperature ionic liquids are non-volatile, thermally stable and highly polar; they are also moderately hydrophilic solvents. Here, we discuss their use as reaction media for biocatalysis. Enzymes of widely diverging types are catalytically active in ionic liquids or aqueous biphasic ionic liquid systems. Lipases...

journal_title：Trends in biotechnology

authors： van Rantwijk F,Madeira Lau R,Sheldon RA

更新日期：2003-03-01 00:00:00

abstract：:Bioelectrochemical power-to-gas (BEP2G) is considered a potentially convenient way of storing renewable surplus electricity in the form of methane. In methane-producing bioelectrochemical systems (BESs), carbon dioxide and electrical energy are converted into methane, using electrodes that supply either electrons or h...

journal_title：Trends in biotechnology

authors： Geppert F,Liu D,van Eerten-Jansen M,Weidner E,Buisman C,Ter Heijne A

更新日期：2016-11-01 00:00:00

abstract：:A major goal of material science is to produce hierarchical materials that are ordered on all length scales, from the molecular (1-100 A) via the nano (10-100 nm) to the meso (1-100 microm). In these materials, the larger-scale properties can be controlled by choosing molecular characteristics. Methods developed to pr...

journal_title：Trends in biotechnology

authors： Dan N

更新日期：2000-09-01 00:00:00

abstract：:Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome ...

journal_title：Trends in biotechnology

authors： Kanchiswamy CN,Malnoy M,Velasco R,Kim JS,Viola R

更新日期：2015-09-01 00:00:00

abstract：:There is a need for techniques that ensure antibiotic removal in anaerobic digesters for robust methane production. In this article, we discuss recent strategies for enhanced antibiotic removal from swine wastewater and offer insights on anaerobic digestion (AD) process design for improved antibiotic removal. ...

journal_title：Trends in biotechnology

authors： Zhou Q,Li X,Wu S,Zhong Y,Yang C

更新日期：2021-01-01 00:00:00

abstract：:Integrated biorefineries have the potential to contribute towards sustainable production of transportation fuels, energy, and chemicals. However, because there are currently no commercial biorefining plants in operation, it is not clear how sustainable they really are. This paper sets out to examine key issues associa...

journal_title：Trends in biotechnology

authors： Azapagic A

更新日期：2014-01-01 00:00:00

abstract：:Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recen...

journal_title：Trends in biotechnology

authors： Cormode DP,Gao L,Koo H

更新日期：2018-01-01 00:00:00

abstract：:Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which relies on the use of nanotechnologies to fight disease, was envisaged to fulfill this coveted goal. Despite substantial progress, the struc...

journal_title：Trends in biotechnology

authors： Lussier F,Staufer O,Platzman I,Spatz JP

更新日期：2020-09-07 00:00:00

abstract：:In this article, the current status of membrane bioreactor (MBR) technology for wastewater treatment is reviewed. Fundamental facets of the MBR process and membrane and process configurations are outlined and the advantages and disadvantages over conventional suspended growth-based biotreatment are briefly identified....

journal_title：Trends in biotechnology

authors： Judd S

更新日期：2008-02-01 00:00:00

abstract：:Microalgal production technologies are seen as increasingly attractive for bioenergy production to improve fuel security and reduce CO(2) emissions. Photosynthetically derived fuels are a renewable, potentially carbon-neutral and scalable alternative reserve. Microalgae have particular promise because they can be prod...

journal_title：Trends in biotechnology

authors： Larkum AW,Ross IL,Kruse O,Hankamer B

更新日期：2012-04-01 00:00:00

abstract：:Precise control of transgene expression is pivotal to the engineering of plants with increased disease resistance. Many early attempts to boost disease resistance used constitutive overexpression of defence components but frequently this resulted in poor quality plants. It is now clear that the extensive cellular repr...

journal_title：Trends in biotechnology

authors： Gurr SJ,Rushton PJ

更新日期：2005-06-01 00:00:00

abstract：:The generation of genetically engineered (GE) foods has been raising several concerns and controversies that divide not only the general public but also the scientific community. The fear and importance of the new technology, as well as commercial interests, have supported many of the ongoing discussions. The recent i...

journal_title：Trends in biotechnology

authors： Batista R,Oliveira MM

更新日期：2009-05-01 00:00:00

abstract：:Despite the wealth of research on stem-cell biology and therapy, there have been few advances in the ex vivo expansion of adult stem cells. Fetal bovine serum, which can elicit an immune reaction in hosts receiving cellular products, remains essential to the culture methods. Recent work by Prockop et al. suggests that...

journal_title：Trends in biotechnology

authors： Horwitz EM

更新日期：2004-08-01 00:00:00

abstract：:The genetic code is the manual that cells use to incorporate amino acids into proteins. It is possible to artificially expand this manual through cellular, molecular, and chemical manipulations to improve protein functionality. Strategies for in vivo genetic code expansion are under the same functional constraints as ...

journal_title：Trends in biotechnology

authors： Ros E,Torres AG,Ribas de Pouplana L

更新日期：2020-09-04 00:00:00

abstract：:Benzylisoquinoline alkaloids (BIAs) are a family of ∼2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to m...

journal_title：Trends in biotechnology

authors： Narcross L,Fossati E,Bourgeois L,Dueber JE,Martin VJJ

更新日期：2016-03-01 00:00:00

abstract：:Antibodies are able to both bind antigens and trigger the responses that eliminate them from circulation. All antibodies are glycosylated at conserved positions in their constant regions, and the presence of carbohydrate can be critical for antigen clearance functions such as complement activation. The structure of th...

journal_title：Trends in biotechnology

authors： Wright A,Morrison SL

更新日期：1997-01-01 00:00:00

abstract：:Traditionally, biotechnology design has focused on the manufacture of chemicals and biologics. Still, a majority of biotechnology products that appear on the market today is the result of mechanical-electric (mechatronic) construction. For these, the biological components play decisive roles in the design solution; th...

journal_title：Trends in biotechnology

authors： Mandenius CF,Björkman M

更新日期：2010-05-01 00:00:00

abstract：:The extensive use of chemical insecticides for insect pest management has resulted in insecticide resistance now being recorded in >500 species of insects and mites. Although gut-active toxins such as those derived from Bacillus thuringiensis (Bt) have been successfully used for insect pest management, a diverse range...

journal_title：Trends in biotechnology

authors： Bonning BC,Chougule NP

更新日期：2014-02-01 00:00:00

abstract：:Bacteriorhodopsin (BR) is the photoactive proton pump found in the purple membrane of the salt marsh archaeon Halobacterium salinarum. Evolution has optimized this protein for high photochemical efficiency, thermal stability and cyclicity, as the organism must be able to function in a hot, stagnant and resource-limite...

journal_title：Trends in biotechnology

authors： Wise KJ,Gillespie NB,Stuart JA,Krebs MP,Birge RR

更新日期：2002-09-01 00:00:00

abstract：:Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to...

journal_title：Trends in biotechnology

authors： Gordon RE,Nemeth JF,Singh S,Lingham RB,Grewal IS

更新日期：2020-08-14 00:00:00

abstract：:Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascularised tissue engineering chamber originates from surgical concepts in tissue prefabrication and microsurgery. It serves as an in vivo bioreactor in the form of a closed, protected space sur...

journal_title：Trends in biotechnology

authors： Yap KK,Yeoh GC,Morrison WA,Mitchell GM

更新日期：2018-10-01 00:00:00

abstract：:It is possible to improve the sensitivity of immunoassays by several orders of magnitude by exploiting nanoenvironmental effects. This approach can detect trace amounts of compounds and will better illuminate the presence of signal substances in biological systems. Here we describe a method for ultrasensitive immunoas...

journal_title：Trends in biotechnology

authors： Mattiasson B,Teeparuksapun K,Lebogang L,Hedström M

更新日期：2017-11-01 00:00:00

abstract：:Targeting apoptotic cell death pathways provides wide-ranging opportunities for the discovery and development of novel drugs. Some targeted therapies that selectively induce apoptosis in cancer cells are already marketed, and numerous pro-apoptotic drugs for treating cancer are currently being developed. The anti-apop...

journal_title：Trends in biotechnology

authors： Alam JJ

更新日期：2003-11-01 00:00:00

abstract：:Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is crit...

journal_title：Trends in biotechnology

authors： Potjewyd G,Moxon S,Wang T,Domingos M,Hooper NM

更新日期：2018-04-01 00:00:00

abstract：:Molecular systems in which fluorescence switches between 'on' and 'off' states when driven by chemical stimuli can be designed according to a few principles. The photochemical mechanisms examined are photoinduced electron transfer, internal charge transfer and excimer formation, with emphasis on the first category. Th...

journal_title：Trends in biotechnology

authors： de Silva AP,Fox DB,Moody TS,Weir SM

更新日期：2001-01-01 00:00:00

abstract：:The therapeutic and commercial success of monoclonal antibodies (mAbs) has inspired innovative approaches aimed at increasing their potency and broadening their applicability. Among these, cocktails of recombinant human mAbs are a logical next step because they combine the technological advances made in the field of a...

journal_title：Trends in biotechnology

authors： Logtenberg T

更新日期：2007-09-01 00:00:00

abstract：:The free-radical gas nitric oxide (NO) plays an important role in a wide and diverse range of physiological processes. As progress is made in understanding the biological function of NO, there is growing interest in the possibility that inhibitors of NO synthase (NOS) may be of clinical use in the therapy of certain d...

journal_title：Trends in biotechnology

authors： Ogden JE,Moore PK

更新日期：1995-02-01 00:00:00

abstract：:The expression 'crystal clear' stems from the science of crystallography, which determines the detailed atomic structures of materials by exposing crystals to X-rays. Protein structures are pivotal to the success of rational drug design and other biotechnology applications; however, obtaining high quality crystals pos...

journal_title：Trends in biotechnology

authors： Saridakis E,Chayen NE

更新日期：2009-02-01 00:00:00

abstract：:Bioremediation differs from other industrial biotechnologies in that, although bioremediation contractors must profit from the activity, the primary driver is regulatory compliance rather than manufacturing profit. It is an attractive technology in the context of a bioeconomy but currently has limitations at the field...

journal_title：Trends in biotechnology

authors： Gillespie IM,Philp JC

更新日期：2013-06-01 00:00:00

abstract：:Chronic diseases, particularly malignancies and immune-mediated inflammatory diseases (IMIDs), are a challenging frontier for clinical diagnosis and treatment, as well as for biomedical research. Current treatment regimens are frequently insufficient and thus new treatment strategies are needed. Novel therapies for di...

journal_title：Trends in biotechnology

authors： Tarner IH,Müller-Ladner U,Fathman CG

更新日期：2004-06-01 00:00:00