Dkk-1-mediated expansion of adult stem cells.

abstract：:Nitrous oxide (N(2)O), the third most abundant greenhouse gas (GHG), is highly stable and plays a significant role in stratospheric ozone destruction. The primary anthropogenic source of N(2)O stems from use of nitrogen fertilizers in soil. The bacterial enzyme nitrous oxide reductase (N(2)OR), naturally found in some...

journal_title：Trends in biotechnology

authors： Wan S,Ward TL,Altosaar I

更新日期：2012-08-01 00:00:00

abstract：:Small molecules are defined as low molecular weight organic compounds (typically <1000 Da), which could be either natural or artificial. Because established imaging methods are not able to selectively detect the positions, concentrations and structures of small molecules in biological samples, new methods have been de...

journal_title：Trends in biotechnology

authors： Svatos A

更新日期：2010-08-01 00:00:00

abstract：:Predicting the future use of biocatalysts for the transformation of organic compounds--both natural substrates and other compounds--needs to take many factors into account. To date, relatively few biotransformations have been developed to the industrial scale, primarily because there has been little economic incentive...

journal_title：Trends in biotechnology

authors： Faber K,Franssen MC

更新日期：1993-11-01 00:00:00

abstract：:Luminescence has assumed an important role in analytical biochemistry and molecular biology as an extremely sensitive method for determining the concentration of specific ions and molecules. The luminescent system of the jellyfish Aequorea victoria consists of the photoprotein aequorin, which contains the molecule coe...

journal_title：Trends in biotechnology

authors： Jones K,Hibbert F,Keenan M

更新日期：1999-12-01 00:00:00

abstract：:Atherosclerosis and heart disease are still the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts but the patency of such grafts is limited compared to natural materials. Tissue engineering, whereby living tissue replacements can be co...

journal_title：Trends in biotechnology

authors： Sales KM,Salacinski HJ,Alobaid N,Mikhail M,Balakrishnan V,Seifalian AM

更新日期：2005-09-01 00:00:00

abstract：:The tricarboxylic acid (TCA) cycle has been used for decades in the microbial production of chemicals such as citrate, L-glutamate, and succinate. Maximizing yield is key for cost-competitive production. However, for most TCA cycle products, the maximum pathway yield is lower than the theoretical maximum yield (Y(E))....

journal_title：Trends in biotechnology

authors： Vuoristo KS,Mars AE,Sanders JPM,Eggink G,Weusthuis RA

更新日期：2016-03-01 00:00:00

abstract：:The announcement that the European Union (EU) had reached an agreement allowing Member States (MS) to ban genetically modified (GM) crops confirms that the EU has chosen to ignore the food security challenge issued to the world by the Food and Agriculture Organization of the United Nations (FAO) in 2009. The FAO sugge...

journal_title：Trends in biotechnology

authors： Smyth SJ,Phillips PWB,Kerr WA

更新日期：2016-07-01 00:00:00

abstract：:Since its inception a decade ago, sol-gel encapsulation has opened up an intriguing new way to immobilize biological materials. An array of substances, including catalytic antibodies, DNA, RNA, antigens, live bacterial, fungal, plant and animal cells and whole protozoa, have been encapsulated in silica, metal-oxide, o...

journal_title：Trends in biotechnology

authors： Gill I,Ballesteros A

更新日期：2000-07-01 00:00:00

abstract：:The best long-term prospects for the reduction in the number of deaths due to cancer lie with screening and prevention rather than with therapy of the advanced disease. Screening efficiency will be improved by the identification of individuals at inherited high risk of cancer. Understanding the mechanism of predisposi...

journal_title：Trends in biotechnology

authors： Ponder BA

更新日期：1990-04-01 00:00:00

abstract：:Unbalanced production of atmospheric CO(2) constitutes a major challenge to global sustainability. Technologies have thus been developed for enhanced biological carbon fixation (also referred to as CO(2) mitigation), and one of the most promising capitalizes on microalgae. However, the "best bioreactor", which would b...

journal_title：Trends in biotechnology

authors： Kumar A,Ergas S,Yuan X,Sahu A,Zhang Q,Dewulf J,Malcata FX,van Langenhove H

更新日期：2010-07-01 00:00:00

abstract：:The ascomycete Trichoderma reesei is one of the most well studied cellulolytic microorganisms. This fungus is widely used in the biotechnology industry, mainly in the production of biofuels. Due to its importance, its genome was sequenced in 2008, opening new avenues to study this microorganism. In this 'post-genomic'...

journal_title：Trends in biotechnology

authors： Gupta VK,Steindorff AS,de Paula RG,Silva-Rocha R,Mach-Aigner AR,Mach RL,Silva RN

更新日期：2016-12-01 00:00:00

abstract：:Novel therapeutic strategies that promote wound healing seek to mimic the response of the body to wounding, to regenerate rather than repair injured tissues. Many synthetic or natural biomaterials have been developed for this purpose and are used to deliver wound therapeutics in a controlled manner that prevents unwan...

journal_title：Trends in biotechnology

authors： Andreadis ST,Geer DJ

更新日期：2006-07-01 00:00:00

abstract：:In vitro antibody generation technologies have now been available for two decades. Research reagents prepared via phage display are becoming available and several recent studies have demonstrated that these technologies are now sufficiently advanced to facilitate generation of a comprehensive renewable resource of ant...

journal_title：Trends in biotechnology

authors： Dübel S,Stoevesandt O,Taussig MJ,Hust M

更新日期：2010-07-01 00:00:00

abstract：:Bioremediation differs from other industrial biotechnologies in that, although bioremediation contractors must profit from the activity, the primary driver is regulatory compliance rather than manufacturing profit. It is an attractive technology in the context of a bioeconomy but currently has limitations at the field...

journal_title：Trends in biotechnology

authors： Gillespie IM,Philp JC

更新日期：2013-06-01 00:00:00

abstract：:We review published data on cell/gamete lyophilization. Most studies have utilized the same established protocols for cryopreservation (storage in liquid nitrogen) as for cell lyophilization (dehydration of frozen samples by water sublimation). Surveying natural lyoprotectants, we suggest trehalose and late embryogene...

journal_title：Trends in biotechnology

authors： Loi P,Iuso D,Czernik M,Zacchini F,Ptak G

更新日期：2013-12-01 00:00:00

abstract：:Infrared spectroscopy and microscopy have heralded a period of rapid advances in tissue and cellular characterization during the past decade. However, vibrational spectroscopy is still an analytical tool that is neither familiar nor understood in the medical environment. For many years this field has been mainly drive...

journal_title：Trends in biotechnology

authors： Dumas P,Sockalingum GD,Sulé-Suso J

更新日期：2007-01-01 00:00:00

abstract：:Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of consumables. Although microfluidics has the potential to reduce turnaround times and costs for analytical devices, particularly in medical, veterinary, and environmental sciences, this enabling technology has had limited...

journal_title：Trends in biotechnology

authors： Volpatti LR,Yetisen AK

更新日期：2014-07-01 00:00:00

abstract：:Cyanobacteria promise to be an important industrial platform for the production of a variety of biobased products such as fuels, plastics, and isoprenoids. Recent advances in synthetic biology have resulted in various cyanobacterial strain improvements. Nevertheless, these new strains are still hampered by product inh...

journal_title：Trends in biotechnology

authors： van den Berg C,Eppink MHM,Wijffels RH

更新日期：2019-05-01 00:00:00

abstract：:Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome ...

journal_title：Trends in biotechnology

authors： Kanchiswamy CN,Malnoy M,Velasco R,Kim JS,Viola R

更新日期：2015-09-01 00:00:00

abstract：:Rapid prototyping (RP) technologies are a set of manufacturing processes that can produce very complex structures directly from computer-aided design models without structure-specific tools or knowledge. These technologies might eventually enable the manufacture of human livers to create functional substitutes for tre...

journal_title：Trends in biotechnology

authors： Wang X,Yan Y,Zhang R

更新日期：2007-11-01 00:00:00

abstract：:Molecularly imprinted polymers (MIPs) are prepared by creating a three-dimensional polymeric matrix around a template molecule. After the matrix is removed, complementary cavities with respect to shape and functional groups remain. MIPs have been produced for applications in in vitro diagnostics, therapeutics and sepa...

journal_title：Trends in biotechnology

authors： Poma A,Turner AP,Piletsky SA

更新日期：2010-12-01 00:00:00

abstract：:The field of regenerative medicine has blossomed in recent decades. However, the ultimate goal of tissue regeneration - replacing damaged or aged cells with healthy functioning cells - still faces a number of challenges. In particular, better understanding of the role of the cellular niche in shaping stem cell phenoty...

journal_title：Trends in biotechnology

authors： Del Sol A,Okawa S,Ravichandran S

更新日期：2019-07-01 00:00:00

abstract：:A key aspect of the genomics revolution is the transformation of large amounts of biological information into an electronic format, leading to an information-based approach to biomedical problems. Large-scale RNA assays and gene-expression-microarray studies, in particular, represent the second wave of the genomics re...

journal_title：Trends in biotechnology

authors： Zweiger G

更新日期：1999-11-01 00:00:00

abstract：:There are many aims associated with the optimization of fermentation processes. Optimization is expected to increase the yield of the final product but the process must be compliant with good manufacturing practices, the available equipment and the expected final scale of operation. Dealing with genetically modified m...

journal_title：Trends in biotechnology

authors： Thiry M,Cingolani D

更新日期：2002-03-01 00:00:00

abstract：:N-linked glycoproteins include such biologically important molecules as cell-surface receptors, cell-adhesion molecules, immunoglobulins and other serum proteins, and tumor antigens. Investigating the role of carbohydrate in glycoprotein function has included the use of glycosylation inhibitors or site-directed mutage...

journal_title：Trends in biotechnology

authors： Elbein AD

更新日期：1991-10-01 00:00:00

abstract：:Many of the demands in the production of microalgae at a technical scale cannot presently be met by state-of-the-art cultivation technologies based on suspensions. Immobilized cultivation using porous substrate bioreactors (PSBRs) is characterized by a reduction of liquid reaction volumes by several orders of magnitud...

journal_title：Trends in biotechnology

authors： Podola B,Li T,Melkonian M

更新日期：2017-02-01 00:00:00

abstract：:Cytokine research has yielded a range of products which have now reached the stage of clinical trials and a plethora of novel therapeutics may be expected. Recently, cytokine receptors have also become an area of intensive research. Preliminary results indicate that recombinant soluble receptors can interfere with the...

journal_title：Trends in biotechnology

authors： Maliszewski CR,Fanslow WC

更新日期：1990-11-01 00:00:00

abstract：:Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to...

journal_title：Trends in biotechnology

authors： Gordon RE,Nemeth JF,Singh S,Lingham RB,Grewal IS

更新日期：2020-08-14 00:00:00

abstract：:There is a need for techniques that ensure antibiotic removal in anaerobic digesters for robust methane production. In this article, we discuss recent strategies for enhanced antibiotic removal from swine wastewater and offer insights on anaerobic digestion (AD) process design for improved antibiotic removal. ...

journal_title：Trends in biotechnology

authors： Zhou Q,Li X,Wu S,Zhong Y,Yang C

更新日期：2021-01-01 00:00:00

abstract：:Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recen...

journal_title：Trends in biotechnology

authors： Cormode DP,Gao L,Koo H

更新日期：2018-01-01 00:00:00