Abstract:
:Myocardial infarction leads to structural remodeling of the myocardium, in particular to the loss of cardiomyocytes due to necrosis and an increase in collagen with scar formation. Stem cell regenerative treatments have been shown to alter this remodeling process, resulting in improved cardiac function. As healthy myocardial tissue is highly fibrous and anisotropic, it exhibits optical linear birefringence due to the different refractive indices parallel and perpendicular to the fibers. Accordingly, changes in myocardial structure associated with infarction and treatment-induced remodeling will alter the anisotropy exhibited by the tissue. Polarization-based linear birefringence is measured on the myocardium of adult rat hearts after myocardial infarction and compared with hearts that had received mesenchymal stem cell treatment. Both point measurement and imaging data show a decrease in birefringence in the region of infarction, with a partial rebound back toward the healthy values following regenerative treatment with stem cells. These results demonstrate the ability of optical polarimetry to characterize the micro-organizational state of the myocardium via its measured anisotropy, and the potential of this approach for monitoring regenerative treatments of myocardial infarction.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Wood MF,Ghosh N,Wallenburg MA,Li SH,Weisel RD,Wilson BC,Li RK,Vitkin IAdoi
10.1117/1.3469844subject
Has Abstractpub_date
2010-07-01 00:00:00pages
047009issue
4eissn
1083-3668issn
1560-2281journal_volume
15pub_type
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