Abstract:
:Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) that cause a severe reduction in bouton numbers at neuromuscular junctions (NMJs). In accord with reduced synapse numbers, these NMJs show reduced synaptic transmission. Moreover, lack of postsynaptic DNlg1 leads to deficits in the accumulation of postsynaptic glutamate receptors, scaffold proteins, and subsynaptic membranes, while increased DNlg1 triggers ectopic postsynaptic differentiation via its cytoplasmic domain. DNlg1 forms discrete clusters adjacent to postsynaptic densities. Formation of these clusters depends on presynaptic Drosophila Neurexin (DNrx). However, DNrx binding is not an absolute requirement for DNlg1 function. Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain.
journal_name
Neuronjournal_title
Neuronauthors
Banovic D,Khorramshahi O,Owald D,Wichmann C,Riedt T,Fouquet W,Tian R,Sigrist SJ,Aberle Hdoi
10.1016/j.neuron.2010.05.020subject
Has Abstractpub_date
2010-06-10 00:00:00pages
724-38issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00416-2journal_volume
66pub_type
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