Abstract：
:The hallmark of IgA nephropathy (IgAN) is macroscopic hematuria coinciding with, or immediately following, a mucosal infection, usually of the upper respiratory airways. The role of mucosal pathogens has been proven in different experimental models. Mucosal (or innate) immunity acts through the recognition of pathogen-associated molecular patterns by macrophages, dendritic cells, leukocytes and other cells, and favors opsonization and phagocytosis. Then, mature dendritic cells interact with lymphocytes leading to activation of specific T cell and antibody synthesis. A dysregulation of innate immunity in IgAN is likely to result in failure of mucosal antigen elimination and/or altered IgA synthesis as well as inflammation. Complement system activation is a relevant arm of the innate immunity armamentarium and is associated with IgAN activity and progression. Other powerful mediators of mucosal immunity, Toll-like receptors (TLRs), were reported to modulate the severity of IgAN in ddy mice spontaneously developing IgA deposits, while some new data in peripheral lymphomonocytes of patients with IgAN show TLR hyperexpression particularly during phases of clinical activity. The involvement of innate immunity in IgAN represents a new, exciting field of research.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Coppo R,Amore A,Peruzzi L,Vergano L,Camilla Rsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
626-32issue
6eissn
1121-8428issn
1724-6059pii
10776002-1E8C-4D42-973D-87AD2BB910E0journal_volume
23pub_type
杂志文章,评审abstract：:Membranous glomerulopathy (MGN) is a frequent cause for nephrotic syndrome in adults. In this overview, the basic pathogenic features of Heymann nephritis, a "classical" model of MGN in rats, are compared with those of human MGN. While the pathogenic antigen(s) of rat Heymann nephritis (the polyspecific receptor prote...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:The recent multicenter, randomized, open-label INDEPENDENT study demonstrated that sevelamer improves survival in new to hemodialysis (HD) patients compared with calcium carbonate. The objective of this study was to determine the cost-effectiveness of sevelamer versus calcium carbonate for patients new to HD...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s40620-014-0122-8
更新日期：2015-10-01 00:00:00
abstract：:Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifact...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/JN.2011.8481
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:The aim of this work was to investigate the benefit of basiliximab induction therapy in living-related-donor kidney transplantation. METHODS:One hundred adult recipients of a first kidney allograft were randomized into two treatment groups, one to receive basiliximab and the second as a control. All patient...
journal_title：Journal of nephrology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-05-01 00:00:00
abstract：:Influenza is a commonly encountered and serious pathogen. Patients with end-stage renal disease are more susceptible to serious morbidity and mortality associated with influenza infection. Proper management of patients includes: vaccination, monitoring for symptoms and isolation of potentially infected patients as wel...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-017-0407-9
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.5000193
更新日期：2013-07-01 00:00:00
abstract：:With increasingly accurate non-invasive tests, the clinician frequently discovers obstruction of the renal arteries by atherosclerosis. The decision to reverse this obstruction is not straightforward, particularly when blood pressure can be easily controlled with medications. Proper management of this problem requires...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
abstract：:Inherited distal renal tubular acidosis (dRTA) is caused by impaired urinary acid excretion resulting in hyperchloremic metabolic acidosis. Although the glomerular filtration rate (GFR) is usually preserved, and hypertension and overt proteinuria are absent, it has to be considered that patients with dRTA also suffer ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0370-x
更新日期：2017-06-01 00:00:00
abstract：:Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger 4 and Sodium-dependent Chloride-Bicarbonate Exchanger). Except for AE4 which does not transport Na, all are presumed to mediate the cotransport of Na+ an...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:This study is part of a 3-country study testing whether normal levels of hemoglobin (Hgb) delay the progression of left ventricular (LV) growth in chronic kidney disease (CKD) patients not on dialysis. METHODS:This was an open-label, randomized, multicenter, controlled trial conducted in 27 tertiary-care ho...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:There is growing evidence of the potential properties of nitrate-rich foods against development of hypertension (HTN) and vascular disease. In this study, we investigated the association of nitrate-containing vegetables (NCVs) with risk of HTN after 3 years of follow-up. METHODS:This prospective study was c...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-015-0229-6
更新日期：2016-06-01 00:00:00
abstract：:IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphom...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-018-0544-9
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Peritonitis is the major cause of peritoneal dialysis (PD) technique failure. Prophylactic topical antibiotics have been reported to reduce peritoneal dialysis catheter exit site infections (ESI) and peritonitis rates. METHODS:We audited the effect of different exit site practices in the 12 P...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.5301/jn.5000071
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:No study has evaluated the efficacy of non-calcium-containing phosphate binders in slowing progression of cardiac valve calcification or deterioration of kidney function in patients with chronic kidney disease not on dialysis. This study addressed these issues. METHODS:Outpatients (n = 170) with stage 3-4 c...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.5000290
更新日期：2013-07-01 00:00:00
abstract：:A 59 year-old woman showed rapidly progressive glomerulonephritis during immunotherapy for metastatic renal cell carcinoma. She received unilateral nephrectomy and cytotoxic T lymphocyte (CTL) therapy for the treatment of retroperitoneal lymph node metastasis of renal cell carcinoma. With CTL therapy, her retroperiton...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：:Organ transplantation has proven to be an effective therapeutic for a wide variety of disease states, but the chronic immunosuppression required for allograft survival increases the risk for infection and neoplasia. In the past 50 years, a wealth of experimental data has been accumulated relating to strategies to pres...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2010-05-01 00:00:00
abstract：:Appropriate timing of starting chronic dialysis in patients with advanced chronic kidney disease (CKD) under nephrology care still is undefined. We systematically reviewed the most recent studies that have compared outcomes of stage 5-CKD under conservative versus substitutive treatment. Eleven studies, most in elderl...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-015-0243-8
更新日期：2016-04-01 00:00:00
abstract：:The Liber medicine orinalibus (codex 69 Montecassino) of Hermogenes is the first known manuscript to have a Latin translation from the original Greek work of Magnus of Emesa (or Nisibis). The particular text here translated, from the so-called Commentatio, mentions direct transliteration of Greek concepts such as chym...
journal_title：Journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.5301/JN.2011.6461
更新日期：2011-05-01 00:00:00
abstract：:Urine samples can be readily obtained from patients in everyday clinical practice. Therefore, the availability of urine allows physicians to obtain relevant clinical information in a timely manner. Since the measurement of urinary protein levels is essential in diagnosing and treating a host of diseases, the potential...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-020-00735-y
更新日期：2020-04-23 00:00:00
abstract：:Cyclosporine (CsA) is among the most widely used immunosuppressants for preventing graft rejection and autoimmune diseases. However, its clinical use is hampered by its significant nephrotoxicity and effects as a cause of hypertension. The proximal tubular Na+-H+ exchanger (NHE3) is responsible for transcellular reabs...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2010-11-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is now considered a systemic disease due to the occurrence of extra-hepatic manifestations. Among these, the renal involvement is frequent. HCV infection, in fact, is strongly associated with proteinuria and chronic kidney disease (CKD) and negatively affects the prognosis of renal pa...
journal_title：Journal of nephrology
pub_type： 杂志文章,实务指引
doi：10.1007/s40620-018-0523-1
更新日期：2018-10-01 00:00:00
abstract：:Glomerulonephritis rarely appears associated with Hodgkin's disease or non-Hodgkin's lymphoma (NHL). We present a patient with a relapse of a non-Hodgkin's lymphoma which first presented as nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS). This case report discusses the unusual association of non-Ho...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Rituximab (RTX) is approved for remission induction in ANCA associated vasculitis (AAV). However, data on use of RTX in patients with severe renal disease is lacking. METHODS:We conducted a retrospective multi-center study to evaluate the efficacy and safety of RTX with glucocorticoids (GC) with and without...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.1007/s40620-015-0208-y
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Stenoses of vascular accesses are leading factors limiting access survival. Besides physical examination, screening of access stenoses is based mainly on the "dysfunction hypothesis", which states that progressive stenosis causes graft dysfunction, such as decreased flow. We tested whether Doppler ultrasonog...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:Patients (pts) with primary Membranous nephropathy (MN) have an autoimmune disease caused by autoantibodies against podocyte antigens and 60-80% of them have antibodies directed against the M-type phospholipase A2 receptor (PLA2R). Immunosuppressive treatment is recommended in high-medium risk pts. Recently ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-020-00781-6
更新日期：2020-06-27 00:00:00
abstract：BACKGROUND:The most frequent cause of death in hemodialysis (HD) patients is cardiovascular disease (CVD), and chronic inflammation has been identified as an epidemiologically important risk factor for CVD. Elevated levels of minor acute phase reactants, such as ceruloplasmin (Cp) and transferrin, have been related to ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:Bisphosphonates inhibit bone resorption and are widely used to treat osteolytic metastases and osteoporosis. Renal osteodystrophy patients have continuous bone loss due to chronically elevated parathyroid hormone (PTH). In this open-label study, ibandronate was evaluated for the treatment of reduced bone density in re...
journal_title：Journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:The detailed mechanisms and treatment methods of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) are not fully understood. We conducted a prospective study in CHF patients manifesting CKD to examine if AST-120 (Kremezin) improves cardiac and renal functions. METHODS:Twenty outpatie...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:This review focuses on a series of risk factors involved in the pathogenesis of cardiovascular complications in patients undergoing Regular Dialysis Treatment (RDT). Many of them are not modifiable by any pharmacological strategies or dialysis therapy, others - such as phosphate overload - can be corrected successfull...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:Thales was born into a noble family of Phoenician origin at the time of the 25th Olympiad (floruit 585 bc; he was 40 in the year of the solar eclipse. He had no teachers but had occasion to learn from Egyptian priests. He developed into a scholar and politician very much appreciated by Heraclitus, Herodotus and Democr...
journal_title：Journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2009-11-01 00:00:00
