Lysosome-associated membrane protein 1 is a major SSEA-1-carrier protein in mouse neural stem cells.

abstract：:Affinities of the human blood group glycosyltransferases, alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) for their common acceptor substrate alpha-l-Fucp-(1-->2)-beta-d-Galp-O(CH2)(7)CH3 (1), in the absence and presence of bound uridine 5'-diphosphate (UDP) and Mn2+...

journal_title：Glycobiology

authors： Shoemaker GK,Soya N,Palcic MM,Klassen JS

更新日期：2008-08-01 00:00:00

abstract：:The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence. We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4...

journal_title：Glycobiology

authors： Souady J,Hülsewig M,Distler U,Haier J,Denz A,Pilarsky C,Senninger N,Dreisewerd K,Peter-Katalinic J,Müthing J

更新日期：2011-05-01 00:00:00

abstract：:Bifidobacteria are predominant in the intestines of breast-fed infants and offer health benefits to the host. Human milk oligosaccharides (HMOs) are considered to be one of the most important growth factors for intestinal bifidobacteria. HMOs contain two major structures of core tetrasaccharide: lacto-N-tetraose (Galβ...

journal_title：Glycobiology

authors： Miwa M,Horimoto T,Kiyohara M,Katayama T,Kitaoka M,Ashida H,Yamamoto K

更新日期：2010-11-01 00:00:00

abstract：:The transcriptional regulation mechanisms involved in the up-regulation of Fas-induced GD3 synthase gene have not yet been elucidated. 5'-Rapid amplification of cDNA end (5'-RACE) using mRNA prepared from Fas-induced Jurkat T cells revealed the presence of multiple transcription start sites of human GD3 synthase gene,...

journal_title：Glycobiology

authors： Kang NY,Kang SK,Lee YC,Choi HJ,Lee YS,Cho SY,Kim YS,Ko JH,Kim CH

更新日期：2006-05-01 00:00:00

abstract：:The glycobiology of Schistosoma mansoni is dominated by developmentally regulated expression of various fucosylated structures, most notably the Lewis X epitope and a multifucosylated sequence, Fuc alpha1-->2Fuc alpha1-->, in its various forms. For the infective cercarial stage, Lewis X has been structurally identifie...

journal_title：Glycobiology

authors： Huang HH,Tsai PL,Khoo KH

更新日期：2001-05-01 00:00:00

abstract：:The interaction of heparan sulfate (HS) (and the closely related molecule heparin) with FGF-1 is a requirement for enabling the growth factor to activate its cell surface tyrosine kinase receptor. However, little is known about the regulatory role of naturally occurring cell surface HS in FGF-1 activation. We have add...

journal_title：Glycobiology

authors： Pye DA,Vivès RR,Hyde P,Gallagher JT

更新日期：2000-11-01 00:00:00

abstract：:We have recently demonstrated that the mannose-binding lectins, namely banana lectin (BL) and garlic lectin (GL), interacted with the insulin receptors on M210B4 cells--an established mesenchymal cell line of murine marrow origin--and initiate mitogen-activated protein kinase kinase (MEK)-dependent extracellular signa...

journal_title：Glycobiology

authors： Bajaj M,Hinge A,Limaye LS,Gupta RK,Surolia A,Kale VP

更新日期：2011-04-01 00:00:00

abstract：:We have employed fast atom bombardment mass spectrometry (FAB-MS) to screen the N-linked oligosaccharides of Bowes melanoma tissue plasminogen activator (mt-PA), and recombinant t-PAs produced by Chinese hamster ovary cells (rt-PA) and by a gene-enriched melanoma cell line (rmt-PA). These studies have confirmed the pu...

journal_title：Glycobiology

authors： Chan AL,Morris HR,Panico M,Etienne AT,Rogers ME,Gaffney P,Creighton-Kempsford L,Dell A

更新日期：1991-03-01 00:00:00

abstract：:The common O-glycan core structure in animal glycoproteins is the core 1 disaccharide Galbeta1-3GalNAcalpha1-Ser/Thr, which is generated by the addition of Gal to GalNAcalpha1-Ser/Thr by core 1 UDP-alpha-galactose (UDP-Gal):GalNAcalpha1-Ser/Thr beta1,3-galactosyltransferase (core 1 beta3-Gal-T or T-synthase, EC2.4.1.1...

journal_title：Glycobiology

authors： Ju T,Zheng Q,Cummings RD

更新日期：2006-10-01 00:00:00

abstract：:Asparagine-linked (N-linked) protein glycosylation has been observed in all domains of life, including most recently in bacteria and is now widely considered a universal post-translational modification. However, cell-based production of homogeneous glycoproteins for laboratory and preparative purposes remains a signif...

journal_title：Glycobiology

authors： Guarino C,DeLisa MP

更新日期：2012-05-01 00:00:00

abstract：:We tested the importance of the aspartate-any residue-aspartate (DXD) motif for the enzymatic activity and nucleotide binding capacity of the Golgi glycosyltransferase GM2 synthase. We prepared point mutations of the motif, which is found in the sequence 352-VLWVDDDFV, and analyzed cells that stably expressed the muta...

journal_title：Glycobiology

authors： Li J,Rancour DM,Allende ML,Worth CA,Darling DS,Gilbert JB,Menon AK,Young WW Jr

更新日期：2001-03-01 00:00:00

abstract：:The γ-aminobutyric acid (GABA) transporters (GATs) have long been recognized for their key role in the uptake of neurotransmitters. The GAT1 belongs to the family of Na(+)- and Cl(-)-coupled transport proteins, which possess 12 putative transmembrane (TM) domains and three N-glycosylation sites on the extracellular lo...

journal_title：Glycobiology

authors： Hu J,Fei J,Reutter W,Fan H

更新日期：2011-03-01 00:00:00

abstract：:Mammalian alpha1,6-fucosyltransferase (FUT8) catalyses the transfer of a fucose residue from a donor substrate, guanosine 5'-diphosphate-beta-L-fucose to the reducing terminal N-acetylglucosamine (GlcNAc) of the core structure of an asparagine-linked oligosaccharide. Alpha1,6-fucosylation, also referred to as core fuc...

journal_title：Glycobiology

authors： Ihara H,Ikeda Y,Toma S,Wang X,Suzuki T,Gu J,Miyoshi E,Tsukihara T,Honke K,Matsumoto A,Nakagawa A,Taniguchi N

更新日期：2007-05-01 00:00:00

abstract：:Diabetes mellitus was induced in one group of rats by a single injection of streptozotocin. The glycemia, the body weight, and the blood systolic pressure were measured every week, and the 24 h urine volume and urinary excretions of creatinine, albumin and glycosaminoglycans were measured every 2 weeks. At the end of ...

journal_title：Glycobiology

authors： Cadaval RA,Kohlman O,Michelacci YM

更新日期：2000-02-01 00:00:00

abstract：:We have isolated beta-trace protein from cerebrospinal fluid, serum, plasma, and urine samples of normal volunteers and sera and hemofiltrate of patients with chronic renal failure. Blood-derived and urinary beta-trace have significantly higher molecular weights than their cerebrospinal fluid counterpart, the amino ac...

journal_title：Glycobiology

authors： Hoffmann A,Nimtz M,Conradt HS

更新日期：1997-06-01 00:00:00

abstract：:Endolysins are bacteriophage enzymes that lyse their bacterial host for phage progeny release. They commonly contain an N-terminal catalytic domain that hydrolyzes bacterial peptidoglycan (PG) and a C-terminal cell wall-binding domain (CBD) that confers enzyme localization to the PG substrate. Two endolysins, phage ly...

journal_title：Glycobiology

authors： Ganguly J,Low LY,Kamal N,Saile E,Forsberg LS,Gutierrez-Sanchez G,Hoffmaster AR,Liddington R,Quinn CP,Carlson RW,Kannenberg EL

更新日期：2013-07-01 00:00:00

abstract：:We report the production of biologically active hyaluronan (HA) oligosaccharides labeled with the fluorophore 2-aminobenzoic acid (2AA). Oligosaccharides from 4 to 40 residues in length were purified to homogeneity by ion exchange chromatography using a logarithmic gradient. Molecular weight and purity characterizatio...

journal_title：Glycobiology

authors： Seyfried NT,Blundell CD,Day AJ,Almond A

更新日期：2005-03-01 00:00:00

abstract：:The evolutionarily conserved Notch signaling pathway plays broad and important roles during embryonic development and in adult tissue homeostasis. Unlike most other pathways used during animal development, Notch signaling does not rely on second messengers and intracellular signaling cascades. Instead, pathway activat...

journal_title：Glycobiology

authors： Jafar-Nejad H,Leonardi J,Fernandez-Valdivia R

更新日期：2010-08-01 00:00:00

abstract：:The content of sulfated glycans having 6-O-sulfated GlcNAc residues alters in the course of colonic carcinogenesis. We previously characterized two GlcNAc 6-O-sulfotransferases (SulTs), SulT-a and -b, expressed in colonic normal tissues and adenocarcinomas [Seko et al. (2000) Glycobiology, 10, 919-929]. Levels of the ...

journal_title：Glycobiology

authors： Seko A,Nagata K,Yonezawa S,Yamashita K

更新日期：2002-06-01 00:00:00

abstract：:A number of unusual and rare carbohydrates were tested as potential inhibitors of various glycosidases, as well as inhibitors of N-linked oligosaccharide processing. The best inhibitors of several arylglycosidases and of glucosidase I were L-xylulose and L-fructose. Both of these sugars showed some inhibitory activity...

journal_title：Glycobiology

authors： Muniruzzaman S,Pan YT,Zeng Y,Atkins B,Izumori K,Elbein AD

更新日期：1996-12-01 00:00:00

abstract：:The endoplasmic reticulum (ER) quality control system ensures that newly synthesized proteins in the early secretory pathway are in the correct conformation. Polypeptides that have failed to fold into native conformers are subsequently retrotranslocated and degraded by the cytosolic ubiquitin-proteasome system, a proc...

journal_title：Glycobiology

authors： Hosokawa N,Kamiya Y,Kato K

更新日期：2010-06-01 00:00:00

abstract：:Many mannose-binding proteins inhibit divergent strains of human immunodeficiency virus type 1 (HIV-1) in in vitro models of viral infectivity, suggesting that targeting mannose residues in vaccine applications might offset the strain restriction typically observed in antibody responses to HIV vaccine preparations. Co...

journal_title：Glycobiology

authors： Pashov A,MacLeod S,Saha R,Perry M,VanCott TC,Kieber-Emmons T

更新日期：2005-10-01 00:00:00

abstract：:Vesicular integral protein of 36 kDa (VIP36) is an intracellular lectin recognizing high-mannose type glycans and is highly expressed in salivary glands, especially the parotid gland, which secretes alpha-amylase in large quantities. Here immunoelectron microscopy demonstrated that VIP36 was primarily localized to sec...

journal_title：Glycobiology

authors： Hara-Kuge S,Seko A,Shimada O,Tosaka-Shimada H,Yamashita K

更新日期：2004-08-01 00:00:00

abstract：:We investigated the localization of major gangliosides in adult rat brain by an immunofluorescence technique with mouse monoclonal antibodies (MAbs). Five MAbs (GMB16, GMR17, GGR12, GMR5 and GMR13) that specifically recognize gangliosides GM1, GD1a, GD1b, GT1b and GQ1b, respectively, were used. We have found that ther...

journal_title：Glycobiology

authors： Kotani M,Kawashima I,Ozawa H,Terashima T,Tai T

更新日期：1993-04-01 00:00:00

abstract：:Exciting discoveries in many diverse fields of hyaluronan (HA) biology over the last 40 years have centered around the ability of HA to bind cell surface HA receptors (e.g., CD44, Layilin, LYVE-1, HARE/Stab2 and RHAMM) and sometimes also to activate intracellular signal transduction pathways, frequently involving ERK1...

journal_title：Glycobiology

authors： Weigel PH

更新日期：2017-09-01 00:00:00

abstract：:Cancer-associated glycan structures can be both tumor markers and engines of disease progression. The structure Siaα2,6Galβ1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan. Although ST6GAL1/Sia6LacNAc are often overexpressed in colorectal cancer (CRC), their biological an...

journal_title：Glycobiology

authors： Venturi G,Gomes Ferreira I,Pucci M,Ferracin M,Malagolini N,Chiricolo M,Dall'Olio F

更新日期：2019-09-20 00:00:00

abstract：:In this study, a sensitive, straightforward technique is developed for the analysis of glycoprotein O-linked oligosaccharides. Specifically, O-linked oligosaccharides of granulocyte colony-stimulating factor (G-CSF) are analysed by separating charged glycoforms using isoelectric focusing, electroblotting to polyvinyli...

journal_title：Glycobiology

authors： Andersen DC,Goochee CF,Cooper G,Weitzhandler M

更新日期：1994-08-01 00:00:00

abstract：:Trehalose synthase (TreS) catalyzes the reversible conversion of maltose into trehalose in mycobacteria as one of three biosynthetic pathways to this nonreducing disaccharide. Given the importance of trehalose to survival of mycobacteria, there has been considerable interest in understanding the enzymes involved in it...

journal_title：Glycobiology

authors： Caner S,Nguyen N,Aguda A,Zhang R,Pan YT,Withers SG,Brayer GD

更新日期：2013-09-01 00:00:00

abstract：:We developed a new in vitro assay for oligosaccharyltransferase (OST), which catalyzes the transfer of preassembled oligosaccharides on lipid carriers onto asparagine residues in polypeptide chains. The asparagine residues reside in the sequon, Asn-X-Thr/Ser, where X can be any amino acid residue except Pro. We demons...

journal_title：Glycobiology

authors： Kohda D,Yamada M,Igura M,Kamishikiryo J,Maenaka K

更新日期：2007-11-01 00:00:00

abstract：:Glycans mediate a wide variety of biological roles via recognition by glycan-binding proteins (GBPs). Comprehensive knowledge of such interaction is thus fundamental to glycobiology. While the primary binding feature of GBPs can be easily uncovered by using a simple glycan microarray harboring limited numbers of glyca...

journal_title：Glycobiology

authors： Li L,Guan W,Zhang G,Wu Z,Yu H,Chen X,Wang PG

更新日期：2020-04-20 00:00:00