解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The gut microbiota plays a major role in human health and an alteration in gut microbiota structure and function has been implicated in several diseases. In the colon, mucus covering the epithelium is critical to maintain a homeostatic relationship with the gut microbiota by harbouring a microbial community at safe di...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwaa097
更新日期:2020-10-09 00:00:00
abstract::In the present study, we studied anti-Alzheimer's disease (AD) activities of chondroitin sulfate (CS) oligosaccharides with different molecular weights. CS from shark cartilage was degraded by a recombinant CS endolyase, chondroitinase ABC I (CHSase ABC I), and CS disaccharide (DP2), tetrasaccharide (DP4), hexasacchar...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwaa096
更新日期:2020-10-09 00:00:00
abstract::Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs). Strikingly, HMOs are not digested by the infant but function as prebiotics for bacterial strains associated with numerous benef...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwaa028
更新日期:2020-09-28 00:00:00
abstract::β-Trefoil lectins are galactose/N-acetyl galactosamine specific lectins, which are widely distributed across all kingdoms of life and are known to perform several important functions. However, there is no report available on the characterization of these lectins from protozoans. We have performed structural and biophy...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwaa001
更新日期:2020-07-20 00:00:00
abstract::Heparin/heparan sulfates (H/HS) are ubiquitous biopolymers that interact with many proteins to induce a range of biological functions. Unfortunately, how these biopolymers recognize their preferred protein targets remain poorly understood. It is suggested that computational simulations offer attractive avenues but a n...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwaa015
更新日期:2020-07-16 00:00:00
abstract::Circulatory protein glycosylation is a biomarker of multiple disease and inflammatory states and has been applied in the clinic for liver dysfunction, heart disease and diabetes. With the notable exception of antibodies, the liver produces most of the circulatory glycoproteins, including the acute phase proteins relea...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz096
更新日期:2020-04-20 00:00:00
abstract::N-acetylneuraminic acid (5-acetamido-3,5-dideoxy-d-glycero-d-galacto-non-2-ulosonic acid), which is the principal sialic acid family member of the non-2-ulosonic acids and their various derivatives, is often found at the terminal position on the glycan chains that adorn all vertebrate cells. This terminal position com...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz099
更新日期:2020-04-20 00:00:00
abstract::Glycans mediate a wide variety of biological roles via recognition by glycan-binding proteins (GBPs). Comprehensive knowledge of such interaction is thus fundamental to glycobiology. While the primary binding feature of GBPs can be easily uncovered by using a simple glycan microarray harboring limited numbers of glyca...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz100
更新日期:2020-04-20 00:00:00
abstract::Protein N- and O-glycosylation are well known co- and post-translational modifications of immunoglobulins. Antibody glycosylation on the Fab and Fc portion is known to influence antigen binding and effector functions, respectively. To study associations between antibody glycosylation profiles and (patho) physiological...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwz048
更新日期:2020-03-20 00:00:00
abstract::Coccidioides spp. are important pneumonia-causing pathogens of the American southwest, but little is known about their glycobiology and how their glycosylations differ from other pneumonia-causing fungi. There is mounting preliminary evidence to suggest genus or even species-specific glycosylations in the fungal kingd...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz092
更新日期:2020-02-19 00:00:00
abstract::Immunoglobulin G (IgG) glycans are emerging as a new putative biomarker for biological age and different diseases, requiring a robust workflow for IgG glycome analysis, ideally beginning with a simple and undemanding sampling procedure. Here, we report the first comprehensive study on total N-glycans of IgG isolated f...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz061
更新日期:2019-11-20 00:00:00
abstract::Glycosylation is a common modification found on numerous proteins and lipids. However, direct detection of glycans on these intact biomolecules has been challenge. Here, utilizing enzymatic incorporation of fluorophore-conjugated sialic acids, dubbed as direct fluorescent glycan labeling, we report the labeling and de...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz058
更新日期:2019-10-21 00:00:00
abstract::Cancer-associated glycan structures can be both tumor markers and engines of disease progression. The structure Siaα2,6Galβ1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan. Although ST6GAL1/Sia6LacNAc are often overexpressed in colorectal cancer (CRC), their biological an...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz053
更新日期:2019-09-20 00:00:00
abstract::Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes and aberrant sialic acid expression is associated with several pathologies. Sialic acids modulate the characteristics and functions of glycoproteins and regulate cell-cell as well as cel...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz026
更新日期:2019-06-01 00:00:00
abstract::The Minimum Information Required for a Glycomics Experiment (MIRAGE) is an initiative created by experts in the fields of glycobiology, glycoanalytics and glycoinformatics to design guidelines that improve the reporting and reproducibility of glycoanalytical methods. Previously, the MIRAGE Commission has published gui...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz009
更新日期:2019-05-01 00:00:00
abstract::Despite the controversy regarding the importance of protein N-linked glycosylation in species of the genus Plasmodium, genes potentially encoding core subunits of the oligosaccharyltransferase (OST) complex have already been characterized in completely sequenced genomes of malaria parasites. Nevertheless, the currentl...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwz011
更新日期:2019-05-01 00:00:00
abstract::The structure of the O-antigen polysaccharide (PS) from the Shiga-toxin producing Escherichia coli O63 has been elucidated using a combination of bioinformatics, component analyses and NMR spectroscopy. The O-antigen is comprised of tetrasaccharide repeating units with the following structure: →2)-β-d-Quip3N(d-allo-Th...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwy098
更新日期:2019-02-01 00:00:00
abstract::Galactans are linear polysaccharides of β(1→4)-linked galactose residues. Although they can antagonize galectin function, the nature of their binding to galectins needs to be better defined to develop them as drugs. Here, we investigated interactions between galectin-3 (Gal-3) and a series of galactans ranging in weig...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwy085
更新日期:2019-01-01 00:00:00
abstract::Glycosylation is the most common post-translational modification of serum proteins, and changes in the type and abundance of glycans in human serum have been correlated with a growing number of human diseases. While the glycosylation pattern of human serum is well studied, little is known about the profiles of other m...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwy070
更新日期:2018-11-01 00:00:00
abstract::Heparan sulfate (HS) is a sulfated polysaccharide that plays a key role in morphogenesis, physiology and pathogenesis. The biosynthesis of HS takes place in the Golgi apparatus by a group of enzymes that polymerize, epimerize and sulfate the sugar chain. This biosynthetic process introduces varying degrees of sulfate ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwy055
更新日期:2018-11-01 00:00:00
abstract::Since the turn of the century, cancer therapy has undergone a transformation in terms of new treatment modalities and renewed optimism in achieving long-lived tumor control and even cure. This is, in large part, thanks to the widespread incorporation of monoclonal antibodies (mAbs) into standard treatment regimens. Th...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwy043
更新日期:2018-09-01 00:00:00
abstract::Blood dendritic cell antigen 2 (BDCA-2) is a C-type lectin found on the surface of plasmacytoid dendritic cells. It functions as a glycan-binding receptor that downregulates the production of type I interferons and thus plays a role in oligosaccharide-mediated immunomodulation. The carbohydrate recognition domain in B...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwy050
更新日期:2018-08-01 00:00:00
abstract::The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCI...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwy032
更新日期:2018-07-01 00:00:00
abstract::Invariant natural killer T (iNKT) cells recognize glycolipid antigens bound to CD1d molecules on antigen-presenting cells. Therapeutic activation of iNKT cells with the xenogeneic glycolipid α-galactosylceramide (α-GalCer) can prevent and reverse tumor growth in murine models, but clinical trials using α-GalCer-stimul...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwy035
更新日期:2018-07-01 00:00:00
abstract::Human noroviruses (HuNoV), members of the family Caliciviridae, are the major cause of acute viral gastroenteritis worldwide. Successful infection is linked to the ability of the protruding (P) domain of the viral capsid to bind histo-blood group antigens (HBGA). Binding to gangliosides plays a major role for many non...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwx078
更新日期:2017-11-01 00:00:00
abstract::In Campylobacter jejuni, the PglB oligosaccharyltransferase catalyzes the transfer of a heptasaccharide from a lipid donor to asparagine within the D/E-X1-N-X2-S/T sequon (X1,2 ≠ P) or releases this heptasaccharide as free oligosaccharides (fOS). Using available crystal structures and sequence alignments, we identifie...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwx067
更新日期:2017-10-01 00:00:00
abstract::The post-translational glycosylation of select proteins by O-linked mannose (O-mannose or O-man) is a conserved modification from yeast to humans and has been shown to be necessary for proper development and growth. The most well studied O-mannosylated mammalian protein is α-dystroglycan (α-DG). Hypoglycosylation of α...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwx062
更新日期:2017-09-01 00:00:00
abstract::Epithelial cells in the lining of the intestines play critical roles in maintaining homeostasis while challenged by dynamic and sudden changes in luminal contents. Given the high density of glycosylation that encompasses their extracellular surface, environmental changes may lead to extensive reorganization of membran...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwx041
更新日期:2017-09-01 00:00:00
abstract::The polydispersity of hyaluronan (HA) presents challenges for analyzing its solution properties, such as the relationship between mass and particle size. The broad mass range of natural HA (≤50-fold) makes molecular characterization difficult and ambiguous compared to molecules with known molecular weights (e.g., prot...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cwx039
更新日期:2017-09-01 00:00:00
abstract::Exciting discoveries in many diverse fields of hyaluronan (HA) biology over the last 40 years have centered around the ability of HA to bind cell surface HA receptors (e.g., CD44, Layilin, LYVE-1, HARE/Stab2 and RHAMM) and sometimes also to activate intracellular signal transduction pathways, frequently involving ERK1...
journal_title:Glycobiology
pub_type: 杂志文章,评审
doi:10.1093/glycob/cwx056
更新日期:2017-09-01 00:00:00
abstract::In cancer cells, the glycoprotein Mucin 1 (MUC1) undergoes abnormal, truncated glycosylation. The truncated glycosylation exposes cryptic peptide epitopes that can be recognized by antibodies. Since these immunogenic regions are cancer specific, they represent ideal targets for therapeutic antibodies. We investigated ...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww131
更新日期:2017-07-01 00:00:00
abstract::Lectins are used as defense effector proteins against predators, parasites and pathogens by animal, plant and fungal innate defense systems. These proteins bind to specific glycoepitopes on the cell surfaces and thereby interfere with the proper cellular functions of the various antagonists. The exact cellular toxicit...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww113
更新日期:2017-05-01 00:00:00
abstract::The Gram-negative bacterium Campylobacter jejuni 81116 (Penner serotype HS:6) has a class E lipooligosaccharide (LOS) biosynthesis locus containing 19 genes, which encode for 11 putative glycosyltransferases, 1 lipid A acyltransferase and 7 enzymes thought to be involved in the biosynthesis of dideoxyhexosamine (ddHex...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww136
更新日期:2017-04-01 00:00:00
abstract::Xanthomonas translucens pv. translucens (Xtt) is a Gram-negative pathogen of crops from the plant family Poaceae. The lipopolysaccharide (LPS) of Xtt was isolated and chemically characterized. The analyses revealed the presence of rhamnose, xylose, mannose, glucose, galacturonic acid, phosphates, 3-deoxy-D-manno-oct-2...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww093
更新日期:2017-03-15 00:00:00
abstract::Sialyltransferases are a family of 20 gene products in mice and humans that transfer sialic acid from its activated precursor, CMP-sialic acid, to the terminus of glycoprotein and glycolipid acceptors. ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww098
更新日期:2017-01-01 00:00:00
abstract::Glycosyltransferases, usually residing within the intracellular secretory apparatus, also circulate in the blood. Many of these blood-borne glycosyltransferases are associated with pathological states, including malignancies and inflammatory conditions. Despite the potential for dynamic modifications of glycans on dis...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww108
更新日期:2017-01-01 00:00:00
abstract::Tarin, the Colocasia esculenta lectin from the superfamily of α-d-mannose-specific plant bulb lectins, is a tetramer of 47 kDa composed of two heterodimers. Each heterodimer possesses homologous monomers of ~11.9 (A chain) and ~12.7 (B chain) kDa. The structures of apo and carbohydrate-bound tarin were solved to 1.7 Å...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww083
更新日期:2017-01-01 00:00:00
abstract::Polypeptide GalNAc-transferases (GalNAc-Ts) constitute a family of 20 human glycosyltransferases (comprising 9 subfamilies), which initiate mucin-type O-glycosylation. The O-glycoproteome is thought to be differentially regulated via the different substrate specificities and expression patterns of each GalNAc-T isofor...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww111
更新日期:2017-01-01 00:00:00
abstract::Cryptococcus neoformans, an opportunistic fungal pathogen, produces a glycan capsule to evade the immune system during infection. This definitive virulence factor is composed mainly of complex polysaccharides, which are made in the secretory pathway by reactions that utilize activated nucleotide sugar precursors. Alth...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww078
更新日期:2017-01-01 00:00:00
abstract::Endogenous lectins can control critical biological responses, including cell communication, signaling, angiogenesis and immunity by decoding glycan-containing information on a variety of cellular receptors and the extracellular matrix. Galectin-1 (Gal-1), a prototype member of the galectin family, displays only one ca...
journal_title:Glycobiology
pub_type: 杂志文章
doi:10.1093/glycob/cww052
更新日期:2016-12-01 00:00:00