Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.

abstract：:Shigella flexneri is a gram-negative bacterium responsible for serious enteric infections that occur mainly in the terminal ileum and colon. High interest in Shigella, as a human pathogen, is driven by its antibiotic resistance and the necessity to develop a vaccine against its infections. Vaccines of the last generat...

journal_title：Glycobiology

authors： Molinaro A,Silipo A,Castro CD,Sturiale L,Nigro G,Garozzo D,Bernardini ML,Lanzetta R,Parrilli M

更新日期：2008-03-01 00:00:00

abstract：:Protozoan parasites of the genus Leishmania have a glycoconjugate surface coat (the glycocalyx) that acts as the interface between the parasite and its external environment. The principal components of the glycocalyx, the lipophosphoglycans and the glycoinositolphospholipids, have a variety of functions that facilitat...

journal_title：Glycobiology

authors： Smith DF,Rangarajan D

更新日期：1995-03-01 00:00:00

abstract：:Heparan sulfates (HSs) exert critical regulatory actions on many proteins, including growth factors, and are essential for normal development. Variations in their specific sulfation patterns are known to regulate binding and signaling of fibroblast growth factors (FGFs) via tyrosine kinase receptors (FGFRs). We previo...

journal_title：Glycobiology

authors： Ford-Perriss M,Guimond SE,Greferath U,Kita M,Grobe K,Habuchi H,Kimata K,Esko JD,Murphy M,Turnbull JE

更新日期：2002-11-01 00:00:00

abstract：:Galectin 1 (GAL1) is a beta-galactoside-binding lectin involved in cell cycle progression. GAL1 overexpression is associated with neoplastic transformation and loss of differentiation. The gene encoding for human GAL1 resides on chromosome 22(q12; q13), and its expression is developmentally regulated. Although devoid ...

journal_title：Glycobiology

authors： Lutomski D,Fouillit M,Bourin P,Mellottée D,Denize N,Pontet M,Bladier D,Caron M,Joubert-Caron R

更新日期：1997-12-01 00:00:00

abstract：:Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we d...

journal_title：Glycobiology

authors： Troncoso MF,Ferragut F,Bacigalupo ML,Cárdenas Delgado VM,Nugnes LG,Gentilini L,Laderach D,Wolfenstein-Todel C,Compagno D,Rabinovich GA,Elola MT

更新日期：2014-10-01 00:00:00

abstract：:Fucosylation of glycans on glycoproteins and -lipids requires the enzymatic activity of relevant fucosyltransferases and GDP-L-fucose as the donor. Due to the biological importance of fucosylated glycans, a readily accessible source of GDP-L-fucose would be required. Here we describe the construction of a stable recom...

journal_title：Glycobiology

authors： Mattila P,Räbinä J,Hortling S,Helin J,Renkonen R

更新日期：2000-10-01 00:00:00

abstract：:Apicomplexan protozoa are a phylum of parasites that includes pathogens such as Plasmodium, the causative agent of the most severe form of malaria responsible for almost 1 million deaths per year and Toxoplasma gondii causing toxoplasmosis, a disease leading to cerebral meningitis in immunocompromised individuals or t...

journal_title：Glycobiology

authors： Debierre-Grockiego F,Schwarz RT

更新日期：2010-07-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells recognize glycolipid antigens bound to CD1d molecules on antigen-presenting cells. Therapeutic activation of iNKT cells with the xenogeneic glycolipid α-galactosylceramide (α-GalCer) can prevent and reverse tumor growth in murine models, but clinical trials using α-GalCer-stimul...

journal_title：Glycobiology

authors： Melo AM,Zhang L,Dockry ÉF,Petrasca A,Ghnewa YG,Breen EP,Morrissey ME,O'Reilly C,Bruen R,O'Meara A,Lysaght J,Zhu X,Doherty DG

更新日期：2018-07-01 00:00:00

abstract：:N-Glycanase 1, encoded by NGLY1, catalyzes the deglycosylation of misfolded N-linked glycoproteins retrotranslocated into the cytosol. We identified nine cases with mutations in NGLY1. The patients show developmental delay, seizures, peripheral neuropathy, abnormal liver function and alacrima (absence of tears). The m...

journal_title：Glycobiology

authors： He P,Grotzke JE,Ng BG,Gunel M,Jafar-Nejad H,Cresswell P,Enns GM,Freeze HH

更新日期：2015-08-01 00:00:00

abstract：:The transcriptional regulation mechanisms involved in the up-regulation of Fas-induced GD3 synthase gene have not yet been elucidated. 5'-Rapid amplification of cDNA end (5'-RACE) using mRNA prepared from Fas-induced Jurkat T cells revealed the presence of multiple transcription start sites of human GD3 synthase gene,...

journal_title：Glycobiology

authors： Kang NY,Kang SK,Lee YC,Choi HJ,Lee YS,Cho SY,Kim YS,Ko JH,Kim CH

更新日期：2006-05-01 00:00:00

abstract：:The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be disialylated. In contrast, a disialy...

journal_title：Glycobiology

authors： Wang SH,Tsai CM,Lin KI,Khoo KH

更新日期：2013-06-01 00:00:00

abstract：:The transplantation of organs from lower animals such as pigs into humans is prevented by a severe rejection reaction initiated by complement fixing xenoreactive natural antibodies. Most anti-pig xenoreactive natural antibodies in humans are thought to recognize Gal alpha 1-3Gal beta 1-4GlcNAc and are also thought to ...

journal_title：Glycobiology

authors： Parker W,Lateef J,Everett ML,Platt JL

更新日期：1996-07-01 00:00:00

abstract：:Streptococcus macedonicus is a Gram positive lactic acid bacterium that is part of the starter flora present in Greek sheep and goat cheeses. The S. macedonicus Sc136 strain produces a high-molecular-mass, highly texturizing exopolysaccharide composed of D-glucose, D-galactose, and N-acetyl-D-glucosamine in the molar ...

journal_title：Glycobiology

authors： Vincent SJ,Faber EJ,Neeser JR,Stingele F,Kamerling JP

更新日期：2001-02-01 00:00:00

abstract：:N-Acetylglucosaminlyltransferase-V (GnT-V) synthesizes GlcNAcbeta1,6Man branched N-glycans both in vitro and in vivo. A paralog, GnT-Vb (or GnT-IX), has also been shown to synthesize both GlcNAcbeta1,6Man branched N- and O-glycans. GnT-V is expressed in most human and rodent tissues while GnT-Vb expression is limited ...

journal_title：Glycobiology

authors： Alvarez-Manilla G,Troupe K,Fleming M,Martinez-Uribe E,Pierce M

更新日期：2010-02-01 00:00:00

abstract：:A rapid and reproducible method was developed to detect and quantify carbohydrate-mediated cell adhesion to glycans arrayed on glass slides. Monosaccharides and oligosaccharides were covalently attached to glass slides in 1.7-mm-diameter spots (200 spots/slide) separated by a Teflon gasket. Primary chicken hepatocytes...

journal_title：Glycobiology

authors： Nimrichter L,Gargir A,Gortler M,Altstock RT,Shtevi A,Weisshaus O,Fire E,Dotan N,Schnaar RL

更新日期：2004-02-01 00:00:00

abstract：:Heparan sulfate 3-O-sulfotransferase transfers sulfate to the 3-OH position of a glucosamine to generate 3-O-sulfated heparan sulfate (HS), which is a rare component in HS from natural sources. We previously reported that 3-O- sulfotransferase isoform 5 (3-OST-5) generates both an antithrombin-binding site to exhibit ...

journal_title：Glycobiology

authors： Chen J,Duncan MB,Carrick K,Pope RM,Liu J

更新日期：2003-11-01 00:00:00

abstract：:Protein N- and O-glycosylation are well known co- and post-translational modifications of immunoglobulins. Antibody glycosylation on the Fab and Fc portion is known to influence antigen binding and effector functions, respectively. To study associations between antibody glycosylation profiles and (patho) physiological...

journal_title：Glycobiology

authors： de Haan N,Falck D,Wuhrer M

更新日期：2020-03-20 00:00:00

abstract：:Trichomonad species are widespread unicellular flagellated parasites of vertebrates which interact with their hosts through carbohydrate-lectin interactions. In the past, some data have been accumulated regarding their lipo(phospho)glycans, a major glycoconjugate on their cell surfaces; on the other hand, other than b...

journal_title：Glycobiology

authors： Paschinger K,Hykollari A,Razzazi-Fazeli E,Greenwell P,Leitsch D,Walochnik J,Wilson IB

更新日期：2012-02-01 00:00:00

abstract：:The biosynthesis of the Lewis X determinant (Gal beta 1-4 [Fuc alpha 1-3]GlcNAc beta-) in three strains of Helicobacter pylori has been investigated. Strains UA 861, UA 802 and UA 1182 contain alpha 1,3 fucosyltransferase and beta 1,4 galactosyltransferase activities that synthesize the Lewis X structure by the transf...

journal_title：Glycobiology

authors： Chan NW,Stangier K,Sherburne R,Taylor DE,Zhang Y,Dovichi NJ,Palcic MM

更新日期：1995-10-01 00:00:00

abstract：:A rat pheochromocytoma cell line (PC12), when transfected with beta1,4-N-acetylglucosaminyltransferase III (GnT-III), which catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulted in the suppression of neurite outgrowth induced by costimulation of epidermal growth factor (EGF) and integrins. The...

journal_title：Glycobiology

authors： Gu J,Zhao Y,Isaji T,Shibukawa Y,Ihara H,Takahashi M,Ikeda Y,Miyoshi E,Honke K,Taniguchi N

更新日期：2004-02-01 00:00:00

abstract：:Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intrav...

journal_title：Glycobiology

authors： Ogura A,Kurbangalieva A,Tanaka K

更新日期：2016-08-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, the alg2 mutation causes temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol (Jackson et al., Arch. Biochem. Biophys., 272, 203-209, 1989; Huffaker and Robbins, Proc. Natl. Acad. Sci. USA, 80, 7466-7470, 1983). A gene havi...

journal_title：Glycobiology

authors： Jackson BJ,Kukuruzinska MA,Robbins P

更新日期：1993-08-01 00:00:00

abstract：:Tarin, the Colocasia esculenta lectin from the superfamily of α-d-mannose-specific plant bulb lectins, is a tetramer of 47 kDa composed of two heterodimers. Each heterodimer possesses homologous monomers of ~11.9 (A chain) and ~12.7 (B chain) kDa. The structures of apo and carbohydrate-bound tarin were solved to 1.7 Å...

journal_title：Glycobiology

authors： Pereira PR,Meagher JL,Winter HC,Goldstein IJ,Paschoalin VM,Silva JT,Stuckey JA

更新日期：2017-01-01 00:00:00

abstract：:Glycoside hydrolases are particularly abundant in all areas of metabolism as they are involved in the degradation of natural polysaccharides and glycoconjugates. These enzymes are classified into 133 families (CAZy server, http://www.cazy.org) in which members of each family have a similar structure and catalytic mech...

journal_title：Glycobiology

authors： André-Miral C,Koné FM,Solleux C,Grandjean C,Dion M,Tran V,Tellier C

更新日期：2015-04-01 00:00:00

abstract：:We have examined the time course of the neuronal death and regeneration of rat axotomized hypoglossal nerve with various conditions of the nerve resection, and established a useful system to measure neurotrophic activities of bioactive substances. In this system, neuronal death can be evaluated by counting surviving n...

journal_title：Glycobiology

authors： Itoh M,Fukumoto S,Baba N,Kuga Y,Mizuno A,Furukawa K

更新日期：1999-11-01 00:00:00

abstract：:The γ-aminobutyric acid (GABA) transporters (GATs) have long been recognized for their key role in the uptake of neurotransmitters. The GAT1 belongs to the family of Na(+)- and Cl(-)-coupled transport proteins, which possess 12 putative transmembrane (TM) domains and three N-glycosylation sites on the extracellular lo...

journal_title：Glycobiology

authors： Hu J,Fei J,Reutter W,Fan H

更新日期：2011-03-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy which can cause acute quadriplegia. Infection with micro-organisms, including Campylobacter jejuni (C. jejuni), Haemophilus influenzae, and Cytomegalovirus (CMV), is recognized as a main triggering event for the disease. Lipooligosacchari...

journal_title：Glycobiology

authors： Kaida K,Ariga T,Yu RK

更新日期：2009-07-01 00:00:00

abstract：:Asparagine-linked (N-linked) protein glycosylation has been observed in all domains of life, including most recently in bacteria and is now widely considered a universal post-translational modification. However, cell-based production of homogeneous glycoproteins for laboratory and preparative purposes remains a signif...

journal_title：Glycobiology

authors： Guarino C,DeLisa MP

更新日期：2012-05-01 00:00:00

abstract：:Viscumin of mistletoe (Viscum album L.) has a concentration-dependent activity profile unique to plant AB-toxins. It starts with lectin-dependent mitogenicity and then covers toxicity and cell agglutination, associated with shifts in the monomer/dimer equilibrium. Each lectin subunit harbors two sections for ligand co...

journal_title：Glycobiology

authors： Jiménez M,André S,Siebert HC,Gabius HJ,Solís D

更新日期：2006-10-01 00:00:00

abstract：:It is widely reported that derivatives of sugar moieties can be used to metabolically label cell surface carbohydrates or inhibit a particular glycosylation. However, few studies address the effect of substitution of the cytidylmonophosphate (CMP) portion on sialyltransferase activities. Here we first synthesized 2'-O...

journal_title：Glycobiology

authors： Miyazaki T,Angata K,Seeberger PH,Hindsgaul O,Fukuda M

更新日期：2008-02-01 00:00:00