Abstract:
:Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intravenous injections, have been analyzed using conventional dissection studies as well as noninvasive methods such as single photon emission computed tomography, positron emission tomography and fluorescence imaging. These studies suggest that glycan-dependent protein distribution kinetics may be useful for pharmacological and diagnostic applications.
journal_name
Glycobiologyjournal_title
Glycobiologyauthors
Ogura A,Kurbangalieva A,Tanaka Kdoi
10.1093/glycob/cww038subject
Has Abstractpub_date
2016-08-01 00:00:00pages
804-12issue
8eissn
0959-6658issn
1460-2423pii
cww038journal_volume
26pub_type
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