Abstract:
:Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis.
journal_name
Glycobiologyjournal_title
Glycobiologyauthors
Troncoso MF,Ferragut F,Bacigalupo ML,Cárdenas Delgado VM,Nugnes LG,Gentilini L,Laderach D,Wolfenstein-Todel C,Compagno D,Rabinovich GA,Elola MTdoi
10.1093/glycob/cwu054subject
Has Abstractpub_date
2014-10-01 00:00:00pages
907-14issue
10eissn
0959-6658issn
1460-2423pii
cwu054journal_volume
24pub_type
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