Abstract：
BACKGROUNDS:Meningococcal disease remains a serious public health problem worldwide. In Catalonia, after implementing the vaccination program, there has been a significant decrease in cases caused by meningococcus C. METHODS:Reported cases of meningococcal disease between 1997 and 2008 were analyzed to determine the evolution after the introduction of a conjugated vaccine in Catalonia. RESULTS:In < 6 years, the incidence rate of serogroup C fell from 7.6 to 0.6 per 100,000 persons/year in the periods before (1997-2000) and after (2001-2007) the introduction of the conjugate vaccine. In serogroup B, the reduction was from 15.4 to 11.1. In < 20 years case-fatality-rate increased only in serogroup B (3% and 7.4%). Serosubtype P1.15was the most frequent in serogroup B (31%), mainly associated with serotype 4 (80%), and in serogroup C subtype P1.5 (36%), with serotype 2a (86%). During 2008, 5 apparently unrelated cases of B:2a:P1.5 were identified in the same geographic area, with a case-fatality-rate of 80%. CONCLUSIONS:Exhaustive surveillance of circulating meningococcal strains is essential.
journal_name
Rev Esp Salud Publicajournal_title
Revista espanola de salud publicaauthors
Martínez AI,Domínguez A,Oviedo M,Minguell S,Jansà JM,Codina G,Vázquez JA,Grupo de Trabajo sobre Enfermedad Meningocócica de Cataluña.doi
10.1590/s1135-57272009000500013subject
Has Abstractpub_date
2009-09-01 00:00:00pages
725-35issue
5eissn
1135-5727issn
2173-9110pii
S1135-57272009000500013journal_volume
83pub_type
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