Abstract:
:Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in vivo. Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)). Retinal vascular images were captured with a fundus camera system for small animals, and the diameter of retinal blood vessels was measured. Ibudilast (0.1 and 1 mg/kg, intravenously (i.v.)) elicited a sustained increase in the diameter of retinal blood vessels and heart rate without altering systemic blood pressure. The effects of ibudilast were significantly reduced by treatment with the nonselective cyclooxygenase inhibitor indomethacin (5 mg/kg, i.p.). These results suggest that ibudilast dilates retinal blood vessels through cyclooxygenase-dependent mechanisms in rats in vivo.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Noguchi M,Mori A,Sakamoto K,Nakahara T,Ishii Kdoi
10.1248/bpb.32.1924subject
Has Abstractpub_date
2009-11-01 00:00:00pages
1924-7issue
11eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/32.1924journal_volume
32pub_type
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