Validation of serum biomarkers for detection of early- and late-stage endometrial cancer.

Abstract:

OBJECTIVE:The objective of this study was to determine the efficacy of 3 previously described ovarian cancer serum biomarkers (apolipoprotein-1 [ApoA-I], prealbumin [TTR], transferrin [TF]) in the detection of endometrioid and papillary serous adenocarcinoma of the endometrium. STUDY DESIGN:ApoA-I, TTR, and TF levels were measured in serum samples that were obtained from 433 individuals that included 90 women with normal endometrium, 210 women with early-stage endometrial cancer, and 133 women with late-stage endometrial cancer. Multivariate regression models were constructed to evaluate the usefulness of the biomarkers in the detection of endometrial cancer. RESULTS:ApoA-I, TTR, and TF distinguished normal samples from early-stage endometrial cancer with a sensitivity of 71% (specificity, 88%) and normal samples from late stage endometrial cancer with a sensitivity of 82% (specificity, 86%). CONCLUSION:The biomarker panel that consists of ApoA-I, TTR, and TF may prove to be a useful clinical tool for the detection of endometrial cancer.

journal_name

Am J Obstet Gynecol

authors

Farias-Eisner G,Su F,Robbins T,Kotlerman J,Reddy S,Farias-Eisner R

doi

10.1016/j.ajog.2009.07.049

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

73.e1-5

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(09)00837-0

journal_volume

202

pub_type

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