Effect of conjugated estrogens on vaginal blood flow in surgically menopausal women.

Abstract:

:The effect of an intravenous bolus of 25 mg of conjugated estrogen (Premarin) on vaginal blood flow in seven surgically menopausal women was measured by a thermal conductance probe. Electrical power (0.8 W) was supplied to a resistance wire incorporated in the surface of the probe, and its surface temperature was monitored continuously for 30 minutes six times daily for 3 days. The mean temperature difference (delta T) between the heated probe surface and the vagina remained unchanged during a preinjection control day. While there were individual differences in response, analysis of mean delta T during the first day following the injection of the estrogen revealed a significant linear downward trend at delta T, indicating a rise in vaginal blood flow. Delta T plateaued on day 2 and showed a slight rise in the morning of day 3. It may be concluded that estrogen administered in this dose and form markedly increases vaginal blood flow.

journal_name

Am J Obstet Gynecol

authors

Abrams RM,Stanley H,Carter R,Notelovitz M

doi

10.1016/0002-9378(82)90075-8

subject

Has Abstract

pub_date

1982-06-15 00:00:00

pages

375-8

issue

4

eissn

0002-9378

issn

1097-6868

pii

0002-9378(82)90075-8

journal_volume

143

pub_type

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