Relationship of maternal vitamin D level with maternal and infant respiratory disease.

Abstract:

OBJECTIVE:The objective of the study was to investigate the association of maternal vitamin D and maternal asthma and infant respiratory infection severity. STUDY DESIGN:The study included cross-sectional analyses of 340 mother-infant dyads enrolled from September to May 2004-2008 during an infant viral respiratory infection. Maternal vitamin D levels were determined from enrollment blood specimens. At enrollment, we determined self-reported maternal asthma and infant respiratory infection severity using a bronchiolitis score. We assessed the association of maternal vitamin D levels and maternal asthma and infant bronchiolitis score in race-stratified multivariable regression models. RESULTS:The cohort was 70% white, 19% African American, and 21% had asthma. Overall, the median maternal vitamin D level was 20 ng/mL (interquartile range, 14-28). Among white women, a 14 ng/mL increase in vitamin D was associated with a decreased odds of asthma (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86). Maternal vitamin D was not associated with infant bronchiolitis score. CONCLUSION:Higher maternal vitamin D levels were associated with decreased odds of asthma.

journal_name

Am J Obstet Gynecol

authors

Carroll KN,Gebretsadik T,Larkin EK,Dupont WD,Liu Z,Van Driest S,Hartert TV

doi

10.1016/j.ajog.2011.04.002

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

215.e1-7

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)00448-0

journal_volume

205

pub_type

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