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Ovulation induction with luteinizing hormone--releasing hormone in amenorrheic, infertile women.

Abstract：

:Thirteen women with infertility thought due to anovulation were treated with LRH. Etiologic diagnoses of amenorrhea included hypothalamic or "idiopathic" and PCOD. All patients had normal gonadotropins and otherwise normal endocrinologic and infertility evaluations; none had ovulated with clomiphene. Patients were studied for six 35 day cycles, single blind, and received LRH or placebo by subcutaneous injections for 28 days/cycle (LRH dosage 1.0 mg 2 or 3 times each day). Frequent assessments of physical status, cervical mucus, vaginal cytology, and serum LH, FSH, estrogen, and progesterone were performed. Ovulation was documented by basal temperature, serum progesterone and, on occasion, endometrial biopsy. Follow-up was continued for 6 months after therapy. Of the 13 patients treated, eight have ovulated and five have conceived. There were no complications of therapy.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Hammond CB,Wiebe RH,Haney AF,Yancy SG

doi

10.1016/0002-9378(79)90819-6

subject

Has Abstract

pub_date

1979-12-01 00:00:00

pages

924-39

issue

7

eissn

0002-9378

issn

1097-6868

pii

0002-9378(79)90819-6

journal_volume

135

pub_type

临床试验,杂志文章

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