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Placental angiogenesis markers sFlt-1 and PlGF: response to cigarette smoke.

Abstract：

OBJECTIVE:Excess soluble vascular endothelial growth factor receptor, fms-like tyrosine kinase-1 (sFlt-1), and reduced placental growth factor (PlGF) mediate the genesis of preeclampsia. Cigarette smoking reduces the risk of preeclampsia. We hypothesized that placental secretion of sFlt-1 and PlGF was affected by exposure to cigarette smoke extract. STUDY DESIGN:Term placental villous explants were cultured with cigarette smoke extract. Media were analyzed for sFlt-1 and PlGF. Apoptosis was measured by TUNEL staining. Results are reported as sFlt-1 or PlGF picogram/milliliter/milligram wet weight of explant. RESULTS:Exposure to cigarette smoke extract reduced secretion of sFlt-1 in a dose-dependent manner. There was no difference in apoptosis. In contrast with sFlt-1, PlGF did not decline when incubated with cigarette smoke extract. CONCLUSION:Exposure of placental villous explants to cigarette smoke extract results in a proangiogenic state with reduced sFlt-1 and relative abundance of PlGF. This is the reverse of changes that are seen in preeclampsia and may explain the reduction of preeclampsia in smokers.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Mehendale R,Hibbard J,Fazleabas A,Leach R

doi

10.1016/j.ajog.2007.06.025

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

363.e1-5

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(07)00754-5

journal_volume

197

pub_type

杂志文章

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