Abstract：
:Linear growth in fetuses with trisomy 18 has not been systematically described. We studied the relationship between long-bone, crown-rump, and foot length and gestational age in 17 postmortem fetal specimens with this syndrome. Long-bone and crown-rump lengths were compared with normal regression lines and foot length was compared with gestational age determined on the basis of menstrual dates. Correlation between foot length and menstrual dates was weak in trisomy 18. Gestational age predicted by crown-rump length was significantly lower than gestational age by menstrual dates. All long bones were significantly shortened and fell below normal regression lines for gestational age. The fetal femur/foot length ratio was reduced. Thus no endogenous measure of gestational age appears to exist in this aneuploidy, forcing reliance on menstrual dates. The observed pattern of growth alterations will likely preclude the development of a gestational age-dependent biometric screen for the prenatal detection of this syndrome.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Droste S,FitzSimmons J,Pascoe-Mason J,Shepard THdoi
10.1016/s0002-9378(11)90691-7subject
Has Abstractpub_date
1990-07-01 00:00:00pages
158-61issue
1 Pt 1eissn
0002-9378issn
1097-6868pii
S0002-9378(11)90691-7journal_volume
163pub_type
杂志文章abstract：:Studies on mouse sperm-egg binding and fertilization have been suggested to involve the interaction of sperm-associated beta 1-4 galactosyltransferase with egg zona pellucida glycoproteins. A population of human males, whose sperm demonstrated an inability to penetrate ovulated zona pellucida-free hamster eggs in vitr...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90180-4
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:Hemolytic disease of the fetus and newborn infant (HDFN) can be associated with bilirubin encephalopathy, which is usually averted through neonatal exchange transfusions (EXT). However, EXT can be associated with significant procedure-related morbidity. We hypothesized that maternal oral administration of phe...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2004.08.016
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the role of previous term delivery on the rate of recurrent preterm birth in women with previous spontaneous preterm delivery (SPTD) who receive 17-alphahydroxyprogesterone caproate (17P) therapy. STUDY DESIGN:Women with singleton gestations who were receiving 17P t...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2011.06.039
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:Our purpose was to determine the adequacy of oxygenation, particularly cranial and cardiac oxygenation, in exteriorized fetal lambs on right atrium to artery extracorporeal membrane oxygenation. STUDY DESIGN:Thirteen fetal lambs were placed on right atrium to artery extracorporeal membrane oxygenation betwee...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(96)70423-4
更新日期：1996-02-01 00:00:00
abstract：:Chromosomal studies in patients with polycystic ovary disease have produced contradictory findings. Whereas some patients showed various sex-chromosome anomalies, the majority had a normal karyotype. However, banding techniques were not employed in any of those studies. This report presents the result of cytogenetic s...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(15)33238-5
更新日期：1980-07-15 00:00:00
abstract：OBJECTIVE:We sought to determine whether the transfer of enzyme-encoding genes in utero can be detected after birth. STUDY DESIGN:An adenoviral vector carrying the gene for beta-galactosidase was injected under ultrasonographic guidance into the livers of 4 rabbit fetuses per litter (3 litters total) at 27 days' gesta...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(99)70312-1
更新日期：1999-10-01 00:00:00
abstract：:To study the relationship between endometriosis and ovulatory dysfunction, we induced ovarian endometriosis in the rabbit model Adipose tissue was placed in the contralateral ovary as a control. Ovulation was induced with human chorionic gonadotropin, and ovulation points were counted before and after induction of end...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90083-5
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:In a previous report, we described the results of a randomized, controlled trial that evaluated the potential of raloxifene to induce or exacerbate hot flushes. Here, we provide additional analyses that were undertaken to identify potential predictors of hot flushes and to assess the clinical usefulness of va...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajog.2004.04.042
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to test the hypothesis that cocaine alters placental prostaglandin production in vitro. STUDY DESIGN:Placentas were obtained from healthy women (n = 6) after normal vaginal delivery at term. Placental explants (300 mg) were incubated in duplicate at 37 degrees C in the presenc...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(94)90015-9
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVE:Our purpose was to measure the transfer of lamivudine ([-]-2'-deoxy-3'-thiacytidine) across the human placenta both alone and in the presence of zidovudine. STUDY DESIGN:Nine placentas from term, elective cesarean deliveries were analyzed with use of the ex vivo single cotyledon perfusion system. Antipyrine ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(97)70487-3
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVE:Our purpose was to demonstrate the clinical efficacy and effect of hormone replacement therapy in menopause on quality of life. STUDY DESIGN:A randomized, open, 6-month comparison of hormone replacement therapy (estradiol transdermal system [Estraderm TTS] plus chlormadinone) and symptomatic treatment (verap...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0002-9378(94)70239-x
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:Our purpose was to compare the estimated maternal cerebral perfusion pressure and an index of vascular resistance, the resistance area product, in nonpregnant women with hypertensive pregnant women. STUDY DESIGN:The maternal middle cerebral artery was evaluated by transcranial Doppler ultrasonography in 17 n...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(98)70131-0
更新日期：1998-11-01 00:00:00
abstract：:To clarify the possible immunologic functions of the endometrium before implantation, supernatants from explant cultures of human endometrial tissues were examined for effects on mixed lymphocyte reaction and phytohemagglutinin M-stimulated cultures. Supernatants obtained from both proliferative and secretory phase en...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(87)80095-9
更新日期：1987-10-01 00:00:00
abstract：:One or more infants of a multifetal pregnancy occasionally require delivery selectively because of in utero risk of fetal death in circumstances in which the sibling fetus appears well. At 26 weeks 5 days of gestation a small fundally placed twin in a dichorionic gestation had an estimated fetal weight of 650 g with d...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(98)70285-6
更新日期：1998-07-01 00:00:00
abstract：:One hundred randomly selected nulliparous, normotensive women were subjected to the roll-over test between 28 and 32 weeks' gestation. Twenty-five women had a positive test. Thirteen of those 25 women developed pre-eclampsia requiring magnesium sulfate therapy. Eight had transient hypertension during labor requiring n...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(77)90362-3
更新日期：1977-03-15 00:00:00
abstract：OBJECTIVES:Our purpose was to develop a method to induce premature delivery in rats and to use this method to identify biochemical changes that are critical to cervical dilatation by comparison to changes that occur during term delivery. STUDY DESIGN:Rats were treated with antiprogestational agents onapristone or lilo...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1053/ob.1996.v175.a74254
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate the use of the Lens culinaris agglutinin-reactive alpha-fetoprotein ratio for the detection of fetal Down syndrome in combination with traditional serum markers. STUDY DESIGN:We obtained maternal serum from 530 women with unaffected pregnancies and 31 women who were ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2002.123201
更新日期：2002-07-01 00:00:00
abstract：:Leiomyomas most frequently occur in the genitourinary and gastrointestinal system. This report discusses clinical and pathologic findings of 2 leiomyomas in the pubovesical space, a location that has not been described before. Different operative approaches were used for excision. Immunohistochemical examination for t...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2001.114503
更新日期：2001-07-01 00:00:00
abstract：:Available information suggests that some instances of preterm birth or premature rupture of membranes are associated with clinically unrecognized infection and inflammation of the lower uterine segment, decidua, and fetal membranes. Various cervicovaginal microorganisms have been recovered from these sites. Many of th...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9378(90)90632-h
更新日期：1990-11-01 00:00:00
abstract：:The purpose of this study was to determine the activity and toxicity of hexamethylmelamine chemotherapy in patients with persistent or recurrent epithelial ovarian cancer. Forty-nine women received hexamethylmelamine 100 to 150 mg/day for 14 days, repeated at 4-week intervals. All patients had previously received at l...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9378(91)90287-2
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:Our purpose was to compare the effects of the Burch colposuspension with those of the modified Marshall-Marchetti-Krantz urethropexy. STUDY DESIGN:Eighty women underwent the two types of operation. A full urodynamic investigation was repeated 6 months after surgery. RESULTS:Clinical follow-up continued for ...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-9378(94)90404-9
更新日期：1994-12-01 00:00:00
abstract：:The aim of this study was to observe the sequential effects of oxygenation, umbilical cord occlusion, and finally cooling on circulating catecholamines and nonshivering thermogenesis in fetal sheep. We studied five fetal sheep at 132 +/- 3 days' gestation. The fetuses were first ventilated with oxygen; PaO2 levels wer...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(91)90655-b
更新日期：1991-01-01 00:00:00
abstract：:In a multicenter comparative trial, 15-methyl prostaglandin F2alpha(PGF2alpha), 0.92 mg., was administered by extra-amniotic injection to 660 patients. Abortion of the fetus occurred within 24 hours in 479 patients (72.6 per cent) and within 36 hours in 530 patient (80.3 per cent). Abortion was complete in 31 per cent...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1977-11-15 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the reported diagnostic accuracy, the validity, and the current limitations of fetal Rh genotyping from peripheral maternal blood based on the existing English-written publications. STUDY DESIGN:A search of the English literature describing fetal RhD determination f...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ajog.2006.07.033
更新日期：2006-10-01 00:00:00
abstract：:Partial colpocleisis, in comparison with complete colpocleisis, offers several advantages. The most obvious advantage is the avoidance of recurrent prolapse in sexually nonactive, older patients. Historically, colpocleisis has been reported to produce stress incontinence, which may be avoided by partial colpocleisis. ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(86)90699-x
更新日期：1986-06-01 00:00:00
abstract：:Chlamydia trachomatis is a bacterium that causes both symptomatic and asymptomatic infection. This infection has been associated with severe infections of the upper genital tract, such as salpingitis, which may be responsible for a significant number of cases of ectopic pregnancy and infertility. An unsettled question...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/0002-9378(91)90558-9
更新日期：1991-06-01 00:00:00
abstract：:The Reproductive Sciences Branch of the National Institutes of Child Health and Human Development has created pioneering new research and research training programs that address the impending shortage of physician-scientists in obstetrics, gynecology, and women's health and the need to bolster translational and clinic...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2002.125896
更新日期：2002-10-01 00:00:00
abstract：:We have studied the effects of magnesium sulfate (MgSO4) administration in chronically instrumented normotensive and hypertensive pregnant sheep. Animals of 90 to 144 days' gestation were divided in two groups; those with normotensive arterial pressure and those in which renovascular hypertension had been produced. Ou...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(77)90255-1
更新日期：1977-04-01 00:00:00
abstract：:The present investigation was designed to reassess the fractional postcoital test (PCT). Specifically, the study addressed the question of whether the internal cervical mucus sperm count is significantly different from the sperm counts at other cervical levels. By means of standardized methodology, 25 normal postcoita...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(79)90056-5
更新日期：1979-02-15 00:00:00
abstract：:A randomized prospective trial was performed to compare the efficacy and safety of ritodrine and indomethacin in the long-term treatment of preterm labor. Forty patients with intact membranes in preterm labor at 23 to 34 weeks' gestation were randomized to receive either intravenous ritodrine or oral indomethacin as t...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-9378(91)90569-d
更新日期：1991-04-01 00:00:00
