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Altered gene expression patterns in intrauterine growth restriction: potential role of hypoxia.

Abstract：

OBJECTIVE:Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). In our study, microarray technology was used to identify genes, which may impair placentation resulting in IUGR. STUDY DESIGN:The RNA was isolated from both IUGR term placentas and normal term placentas. Microarray experiments were used to identify differentially expressed genes between the 2 cohorts. Real-time quantitative reverse transcriptase polymerase chain reaction and immunohistochemistry were used in follow-up experiments. RESULTS:Microarray experiments identified increased expression of certain genes including leptin, soluble vascular endothelial growth factor receptor, human chorionic gonadotropin, follistatin-like 3, and hypoxia-inducible factor 2alpha in the IUGR. Real-time quantitative polymerase chain reaction confirmed these results. CONCLUSION:The upregulation of soluble vascular endothelial growth factor receptor and hypoxia-inducible factor 2alpha at this period in pregnancy indicate that placental angiogenesis is altered in IUGR and that hypoxia is a major contributor to maldevelopment of the placental vasculature.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

McCarthy C,Cotter FE,McElwaine S,Twomey A,Mooney EE,Ryan F,Vaughan J

doi

10.1016/j.ajog.2006.08.027

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

70.e1-6

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(06)01165-3

journal_volume

196

pub_type

杂志文章

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