Blood protein profiles of infants born before 28 weeks differ by pregnancy complication.

Abstract:

OBJECTIVE:Disorders that lead to preterm delivery influence the fetal inflammatory response. STUDY DESIGN:We calculated odds ratios of elevated concentrations of 25 blood proteins on the first postnatal day in 798 infants born before the 28th week and classified by the pregnancy disorder that lead to preterm delivery. RESULTS:Concentrations of cytokines (IL-1β, IL-6, TNFα), cytokine receptors (IL-6R, TNF-R1, TNF-R2), systemic inflammatory proteins (CRP, SAA, MPO), chemokines (IL-8, MCP-1, MCP-4, MIP-1β, RANTES, I-TAC), adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin), and metalloproteinases (MMP-1, MMP-9) were elevated in children delivered after preterm labor, membrane rupture, abruption, and cervical insufficiency, whereas such a pattern was not seen after preeclampsia or fetal indication/growth restriction. Inflammatory profiles were also associated with maternal vaginitis. CONCLUSION:The patterns of blood proteins in the newborn support the division of pregnancy disorders that lead to preterm delivery into those associated, and those not associated, with inflammation.

journal_name

Am J Obstet Gynecol

authors

McElrath TF,Fichorova RN,Allred EN,Hecht JL,Ismail MA,Yuan H,Leviton A,ELGAN Study Investigators.

doi

10.1016/j.ajog.2010.12.010

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

418.e1-418.e12

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)02426-9

journal_volume

204

pub_type

杂志文章
  • Medical and obstetric outcomes among pregnant women with tuberculosis: a population-based study of 7.8 million births.

    abstract:BACKGROUND:Worldwide, tuberculosis remains a major health concern, with an estimated 9.6 million people infected in the year 2014, of which one-third were women. Tuberculosis is estimated to be even more prevalent in pregnant women than the general population. To date there has been conflicting evidence on the maternal...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2016.08.009

    authors: El-Messidi A,Czuzoj-Shulman N,Spence AR,Abenhaim HA

    更新日期:2016-12-01 00:00:00

  • Interrelationship and clinical significance of increased resistance in the uterine arteries in patients with hypertension or preeclampsia or both.

    abstract:OBJECTIVES:This study was designed to evaluate the clinical significance of the Doppler flow velocity waveform analysis of the two uterine arteries on an individual basis and in combination expressed as the mean uterine artery. STUDY DESIGN:We evaluated uterine artery resistance by means of continuous wave Doppler ult...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(92)91683-2

    authors: Kofinas AD,Penry M,Simon NV,Swain M

    更新日期:1992-02-01 00:00:00

  • Symptomatic and anatomic 1-year outcomes after robotic and abdominal sacrocolpopexy.

    abstract:OBJECTIVE:The purpose of this study was to compare symptomatic and anatomic outcomes 1 year after robotic vs abdominal sacrocolpopexy. STUDY DESIGN:Our retrospective cohort study compared women who underwent robotic sacrocolpopexy (RSC) with 1 surgeon to those who underwent abdominal sacrocolpopexy (ASC) as part of th...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ajog.2012.01.035

    authors: Siddiqui NY,Geller EJ,Visco AG

    更新日期:2012-05-01 00:00:00

  • Characteristics of sexual assault in women with a major psychiatric diagnosis.

    abstract:OBJECTIVE:In a previous study of women who had been sexually assaulted, we reported a 26% prevalence of a major psychiatric diagnosis. The purpose of this study was to better characterize sexual assaults in women with a major psychiatric diagnosis. STUDY DESIGN:All female patients >or=15 years old with a complaint of ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2002.123731

    authors: Eckert LO,Sugar N,Fine D

    更新日期:2002-06-01 00:00:00

  • Safe prevention of the primary cesarean delivery.

    abstract::In 2011, 1 in 3 women who gave birth in the United States did so by cesarean delivery. Cesarean birth can be lifesaving for the fetus, the mother, or both in certain cases. However, the rapid increase in cesarean birth rates from 1996 through 2011 without clear evidence of concomitant decreases in maternal or neonatal...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2014.01.026

    authors: American College of Obstetricians and Gynecologists (College).,Society for Maternal-Fetal Medicine.,Caughey AB,Cahill AG,Guise JM,Rouse DJ

    更新日期:2014-03-01 00:00:00

  • Betamethasone and the rhesus fetus: multisystemic effects.

    abstract::In this controlled study of betamethasone administration to pregnant rhesus monkeys, using dosages per gram of fetal body weight similar to those reported in several human clinical studies, the most significant fetal pulmonary changes observed were increases in maximum lung volumes. The fact that comparable increases ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(79)90018-8

    authors: Johnson JW,Mitzner W,London WT,Palmer AE,Scott R

    更新日期:1979-03-15 00:00:00

  • Mode of delivery for the morbidly obese with prior cesarean delivery: vaginal versus repeat cesarean section.

    abstract:OBJECTIVE:We sought to describe the peripartum outcome of women weighing >300 pounds (135 kg) who were candidates for trial of labor after a prior cesarean delivery. STUDY DESIGN:All pregnant women who weighed in excess of 300 pounds and had a prior cesarean delivery were included in this prospective investigation. St...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2001.116729

    authors: Chauhan SP,Magann EF,Carroll CS,Barrilleaux PS,Scardo JA,Martin JN Jr

    更新日期:2001-08-01 00:00:00

  • Evaluation of an impedance measurement technique for uterine contraction recording.

    abstract::An electronic system for the detection of uterine contractions by impedance measurement was evaluated in 30 subjects during the first stage of labor. The advantage of the system was patient comfort and ease of application of the recording electrodes. Simultaneous recordings of uterine contraction activity with convent...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(77)90586-5

    authors: Moss PL,Dmytrus KC,Roux JF

    更新日期:1977-10-15 00:00:00

  • Rape: sexual assault.

    abstract::The Rape Treatment Center at Jackson Memorial Hospital, Miami, Florida, has cared for more than 5,000 victims of sexual assault since January, 1974. Forcible rape is a violent crime, and it is now generally accepted that rapists are sexual deviants. Few of the victims have serious physical injuries, but they all suffe...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(16)32834-4

    authors: Hicks DJ

    更新日期:1980-08-15 00:00:00

  • Amniotic fluid intercellular adhesion molecule-1 is a marker for Ureaplasma infection in women with preterm labor.

    abstract:OBJECTIVE:The objective of the study was to determine the amniotic fluid soluble intercellular adhesion molecule-1 concentrations in women with preterm labor in relation to intra-amniotic infection. STUDY DESIGN:Amniotic fluids from 125 women with preterm labor (78 with preterm delivery and 47 with term deliveries) we...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2006.05.020

    authors: Hadar A,Ytzhaki O,Shani-Shrem N,Horowitz S,Mazor M,Horowitz S

    更新日期:2006-12-01 00:00:00

  • The effect of low-dose 3-keto-desogestrel added to a copper-releasing intrauterine contraceptive device on menstrual blood loss: a double-blind, dose-finding, placebo-controlled study.

    abstract:OBJECTIVE:We sought to establish the lowest dose of 3-keto-desogestrel, when added to a copper-releasing intrauterine contraceptive device, that is needed to reduce menstrual blood loss to a very low level and to treat (essential) menorrhagia successfully. STUDY DESIGN:A double-blind group comparative study was design...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mob.2000.104805

    authors: Janssen CA,Scholten PC,Heintz AP

    更新日期:2000-03-01 00:00:00

  • Pelvic girdle pain in pregnancy: the impact of parity.

    abstract:OBJECTIVE:The purpose of this study was to estimate the association of parity with pelvic girdle syndrome (PGS; pain in anterior and bilateral posterior pelvis). STUDY DESIGN:We included 75,939 pregnant women in the Norwegian Mother and Child Cohort Study. Data were obtained by self-administered questionnaires. RESUL...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2010.03.040

    authors: Bjelland EK,Eskild A,Johansen R,Eberhard-Gran M

    更新日期:2010-08-01 00:00:00

  • Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN:A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administer...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mob.2003.41

    authors: da Fonseca EB,Bittar RE,Carvalho MH,Zugaib M

    更新日期:2003-02-01 00:00:00

  • Diagnostic accuracy of fetal choroid plexus length to head biometry ratio at 11 to 13 weeks for open spina bifida.

    abstract:BACKGROUND:Open spina bifida is a major congenital anomaly with an estimated incidence of <1 in 1000. The diagnosis of open spina bifida is usually made during the second trimester, but first-trimester detection rate of spina bifida is increasingly reported. Recently, the mean choroid plexus length to occipitofrontal d...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2020.08.058

    authors: Kalafat E,Ting L,Thilaganathan B,Papageorghiou AT,Khalil A

    更新日期:2020-08-22 00:00:00

  • Paraaortic lymph node sampling by means of an extraperitoneal approach with a supraumbilical transverse "sunrise" incision.

    abstract:OBJECTIVES:Extraperitoneal approaches to removal of lymph nodes for staging in cervical cancer patients are numerous, and each has disadvantages. We developed a supraumbilical transverse incision to initiate irradiation within days of cervical cancer staging. STUDY DESIGN:Twenty patients with advanced stage IIB or III...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(93)90080-3

    authors: Gallup DG,King LA,Messing MJ,Talledo OE

    更新日期:1993-08-01 00:00:00

  • Diagnostic procedures in female urology.

    abstract::Diagnostic procedures in gynecologic urology are no longer limited to the medical history, physical examination, and Marshall test. Newer diagnostic procedures include urethroscopy, urodynamics with cystometry, urethral closure pressure profiles, uroflowmetry, electromyography of the pelvic floor musculature, and radi...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(80)91119-9

    authors: Ostergard DR,McCarthy TA

    更新日期:1980-06-15 00:00:00

  • Vaginal birth after cesarean among women with gestational diabetes.

    abstract:OBJECTIVE:We sought to determine the pregnancy and infant outcomes of women with gestational diabetes who attempted vaginal birth after previous cesarean delivery. STUDY DESIGN:We conducted a retrospective cohort study to compare women with gestational diabetes with matched control subjects without diabetes who attemp...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2001.115176

    authors: Coleman TL,Randall H,Graves W,Lindsay M

    更新日期:2001-05-01 00:00:00

  • Landmarks during the first forty-two days of gestation demonstrated by the beta-subunit of human chorionic gonadotropin and ultrasound.

    abstract::Prospective pregnancy evaluation through the combined use of a radioimmunoassay (RIA) for the beta-subunit of human chorionic gonadotropin (beta-hCG) and ultrasound during the first 42 days of gestation after ovulation was performed on a population asymptomatic for first-trimester spontaneous abortion. One hundred for...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(83)90977-8

    authors: Batzer FR,Weiner S,Corson SL,Schlaff S,Otis C

    更新日期:1983-08-15 00:00:00

  • Distinguishing lymph node metastases from benign glandular inclusions in low-grade ovarian carcinoma.

    abstract::In order to properly stage patients with ovarian carcinoma, we are routinely removing and microscopically examining sample aortic lymph nodes in these patients, since aortic lymph node metastases may affect long-term survival. Inasmuch as benign glandular inclusions can be found in pelvic and aortic lymph nodes, we ha...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(80)90450-0

    authors: Ehrmann RL,Federschneider JM,Knapp RC

    更新日期:1980-03-15 00:00:00

  • Ethnic differences at risk for gestational trophoblastic disease in New Mexico: A 25-year population-based study.

    abstract:OBJECTIVE:The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data. STUDY DESIGN:All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2003.39

    authors: Smith HO,Hilgers RD,Bedrick EJ,Qualls CR,Wiggins CL,Rayburn WF,Waxman AG,Stephens ND,Cole LW,Swanson M,Key CR

    更新日期:2003-02-01 00:00:00

  • Stress urinary incontinence after delayed primary closure of genitourinary fistula: a technique for surgical management.

    abstract:OBJECTIVES:Our purpose was to evaluate the anatomic pathology of severe incontinence after fistula closure and assess a surgical technique for correction of this problem. STUDY DESIGN:Twenty-two women with severe urinary incontinence after fistula closure were recruited, and clinical and urodynamic assessment was perf...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2002.122247

    authors: Carey MP,Goh JT,Fynes MM,Murray CJ

    更新日期:2002-05-01 00:00:00

  • Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses.

    abstract:OBJECTIVE:Our purpose was to evaluate which factors regulate insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses. STUDY DESIGN:We studied 76 singleton births between 25 and 36 weeks of gestation. Forty-nine pregnancies were complicated by hypertensive disease...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2003.26

    authors: Verhaeghe J,Van Herck E,Billen J,Moerman P,Van Assche FA,Giudice LC

    更新日期:2003-02-01 00:00:00

  • Survival after multimodality treatment for stage IIIC endometrial cancer.

    abstract:OBJECTIVE:Our purpose was to review our results of multimodality treatment of lymph node metastasis in endometrial cancer (stage IIIC). STUDY DESIGN:All patients underwent surgical staging for endometrial cancer with complete pelvic and aortic lymphadenectomy. All macroscopic nodal metastases were resected. Patients w...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2001.115225

    authors: Katz LA,Andrews SJ,Fanning J

    更新日期:2001-05-01 00:00:00

  • Women and smoking: an update for the 1990s.

    abstract::Cigarette smoking is associated with many health hazards, ranging from lung cancer to low infant birth weight. In the United States in 1994, 23.1% of all women and 14.6% of pregnant women smoked. Few physicians ask their patients about smoking, although minimal effort by physicians could help many smokers to quit. Thi...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1053/ob.1996.v175.a74919

    authors: Kendrick JS,Merritt RK

    更新日期:1996-09-01 00:00:00

  • Amniocentesis and mother-to-child human immunodeficiency virus transmission in the Agence Nationale de Recherches sur le SIDA et les Hépatites Virales French Perinatal Cohort.

    abstract:OBJECTIVE:The objective of the study was to investigate whether performing an amniocentesis increased mother-to-child transmission of human immunodeficiency virus (HIV)-1 (MTCT). STUDY DESIGN:We studied HIV -1 infected mothers and their children enrolled in the multicenter French Perinatal HIV Cohort from 1985 to 2006...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2008.08.049

    authors: Mandelbrot L,Jasseron C,Ekoukou D,Batallan A,Bongain A,Pannier E,Blanche S,Tubiana R,Rouzioux C,Warszawski J,ANRS French Perinatal Cohort (EPF).

    更新日期:2009-02-01 00:00:00

  • Laminaria versus extra-amniotic saline solution infusion for cervical ripening in second-trimester labor inductions.

    abstract:OBJECTIVE:The aim of this study was to determine which cervical ripening method, laminaria placement or extra-amniotic saline solution infusion, was associated with the shorter interval from induction to delivery in the second trimester. STUDY DESIGN:Women admitted for indicated second-trimester labor induction with a...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mob.2001.112903

    authors: Hogg BB,Owen J

    更新日期:2001-05-01 00:00:00

  • Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use.

    abstract:OBJECTIVE:The objective of this study was to determine whether indomethacin is associated with an increased incidence of constriction of the human fetal ductus arteriosus with advancing gestational age. STUDY DESIGN:A retrospective analysis of fetal echocardiograms performed in 44 patients with premature labor or hydr...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(11)90763-7

    authors: Moise KJ Jr

    更新日期:1993-05-01 00:00:00

  • Effect of a cholesterol-lowering diet during pregnancy on maternal and fetal Doppler velocimetry: the CARRDIP study.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effect of a low-cholesterol low-saturated fat diet on Doppler indices in the fetus and mother. STUDY DESIGN:Two hundred ninety nonsmoking white women, aged 21-38 years, without previous pregnancy complications and carrying a single fetus were assigned randomly to...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ajog.2007.01.017

    authors: Khoury J,Haugen G,Tonstad S,Frøslie KF,Henriksen T

    更新日期:2007-06-01 00:00:00

  • A new look at uterine muscle contraction.

    abstract::Recent progress in our understanding of uterine smooth muscle contraction is reviewed. We no longer believe that actin-myosin interaction in the myometrium occurs through activation of the thin filament; but it is triggered by calcium-dependent phosphorylation of myosin in the thick filament. Calcium is now thought to...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-9378(87)80320-4

    authors: Carsten ME,Miller JD

    更新日期:1987-11-01 00:00:00

  • Transvaginal electrical stimulation for female urinary incontinence.

    abstract:OBJECTIVE:Our purpose was to determine the objective and subjective efficacy of transvaginal electrical stimulation for treatment of common forms of urinary incontinence in women. STUDY DESIGN:A prospective, double-blind, randomized clinical trial included 121 women with either urinary incontinence caused by detrusor ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-9378(97)70142-x

    authors: Brubaker L,Benson JT,Bent A,Clark A,Shott S

    更新日期:1997-09-01 00:00:00