Blood protein profiles of infants born before 28 weeks differ by pregnancy complication.


OBJECTIVE:Disorders that lead to preterm delivery influence the fetal inflammatory response. STUDY DESIGN:We calculated odds ratios of elevated concentrations of 25 blood proteins on the first postnatal day in 798 infants born before the 28th week and classified by the pregnancy disorder that lead to preterm delivery. RESULTS:Concentrations of cytokines (IL-1β, IL-6, TNFα), cytokine receptors (IL-6R, TNF-R1, TNF-R2), systemic inflammatory proteins (CRP, SAA, MPO), chemokines (IL-8, MCP-1, MCP-4, MIP-1β, RANTES, I-TAC), adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin), and metalloproteinases (MMP-1, MMP-9) were elevated in children delivered after preterm labor, membrane rupture, abruption, and cervical insufficiency, whereas such a pattern was not seen after preeclampsia or fetal indication/growth restriction. Inflammatory profiles were also associated with maternal vaginitis. CONCLUSION:The patterns of blood proteins in the newborn support the division of pregnancy disorders that lead to preterm delivery into those associated, and those not associated, with inflammation.


Am J Obstet Gynecol


McElrath TF,Fichorova RN,Allred EN,Hecht JL,Ismail MA,Yuan H,Leviton A,ELGAN Study Investigators.




Has Abstract


2011-05-01 00:00:00














  • Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding: is it always necessary to perform an endometrial biopsy?

    abstract:OBJECTIVE:This study was undertaken to evaluate whether it was possible to abstain from performing an endometrial biopsy when endometrial thickness according to transvaginal ultrasonography was

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章


    authors: Gull B,Carlsson S,Karlsson B,Ylöstalo P,Milsom I,Granberg S

    更新日期:2000-03-01 00:00:00

  • Oxytocin augmentation of dysfunctional labor. II. Uterine activity data.

    abstract::The intrauterine pressure data obtained from oxytocin-treated patients in dysfunctional labor, managed by a specific oxytocin regimen and a computer-defined goal of uterine activity, are analyzed. Questions asked concern the efficacy of the computer diagnosis of hypocontractility, the quantity of uterine activity need...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Seitchik J,Castillo M

    更新日期:1983-03-01 00:00:00

  • Concurrence of mouthing movement and rapid eye movement/non-rapid eye movement phases with advance in gestation of the human fetus.

    abstract::To evaluate whether mouthing movement in the human fetus is related to advance in gestational age and whether such movement is concurrent with rapid eye movement or non-rapid eye movement phases, 26 fetuses from 28 to 41 weeks' gestation were observed for 60 continuous minutes with real-time ultrasonography. It was ev...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Horimoto N,Koyanagi T,Nagata S,Nakahara H,Nakano H

    更新日期:1989-08-01 00:00:00

  • Power over parity: intimate partner violence and issues of fertility control.

    abstract:OBJECTIVE:The purpose of this study was to examine the association between intimate partner violence (IPV), abortion, parity, and contraception use. STUDY DESIGN:We recruited 1463 women for this written questionnaire study of IPV. Patient demographics, contraceptive history, and reproductive history were obtained in t...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gee RE,Mitra N,Wan F,Chavkin DE,Long JA

    更新日期:2009-08-01 00:00:00

  • An evaluation of the sensitivity of five home pregnancy tests to known concentrations of human chorionic gonadotropin.

    abstract::A study was conducted to evaluate the sensitivity of the five commercially available home pregnancy testing kits. Known amounts of human chorionic gonadotropin (hCG) were diluted in pooled, sterile male urine. Varying concentrations of hCG were randomly assigned to 100 kits of each of the five brands. The test results...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hanlon JT,Caiola SM,Muhlbaier LH,Dennis BH,Edelman DA,Dingfelder JR

    更新日期:1982-12-01 00:00:00

  • The gonadotropin-releasing hormone antagonist (Nal-Glu) acutely blocks the luteinizing hormone surge but allows for resumption of folliculogenesis in normal women.

    abstract::The gonadotropin-releasing hormone antagonist offers several advantages over the use of the agonist and allows several physiologic questions to be addressed. In this study, we evaluated the ability of Nal-Glu to acutely inhibit the luteinizing hormone surge and prevent ovulation. We also assessed whether recovery of t...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ditkoff EC,Cassidenti DL,Paulson RJ,Sauer MV,Paul WL,Rivier J,Yen SS,Lobo RA

    更新日期:1991-12-01 00:00:00

  • The impact of prenatal care in different social groups.

    abstract::An analysis of United States birth certificate records for the calendar year 1977 indicated that women who failed to seek prenatal care were at increased risk of delivery of a low-birth weight infant, even after social factors were considered. However, the strength of association, as well as the population impact, bet...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Greenberg RS

    更新日期:1983-04-01 00:00:00

  • Production and origin of estrogen in two true hermaphrodites.

    abstract::Two 46,XX true hermaphrodites with genital ambiguity since birth and gynecomastia were studied. The production rates of estradiol in these subjects, 77 and 71 microgram per 24 hours, and of estrone, 82 and 136 microgram per 24 hours, were approximately twice those of normal adult men. In one of these subjects the plas...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Aiman J,Hemsell DL,MacDonald PC

    更新日期:1978-10-15 00:00:00

  • Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of recombinant human relaxin on the uterine artery and myometrial contractility in pregnant rats. STUDY DESIGN:Uterine artery and myometrial rings from mid and term pregnant rats were used. Relaxin effect was studied on phenylephrine-induced contraction i...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Longo M,Jain V,Vedernikov YP,Garfield RE,Saade GR

    更新日期:2003-06-01 00:00:00

  • Benefits, risks, costs, and patient satisfaction associated with insulin pump therapy for the pregnancy complicated by type 1 diabetes mellitus.

    abstract:OBJECTIVE:Glycemic control, perinatal outcome, and health care costs were evaluated among women with type 1 diabetes mellitus who began insulin pump therapy during pregnancy (group 1, n = 24), were treated with multiple insulin injections (group 2, n = 24), or were already using an insulin pump before pregnancy (group ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gabbe SG,Holing E,Temple P,Brown ZA

    更新日期:2000-06-01 00:00:00

  • Vaginal birth after cesarean (VBAC) attempt in twin pregnancies: is it safe?

    abstract:OBJECTIVE:The purpose of this study was to compare the rate of vaginal birth after cesarean (VBAC) attempt, VBAC failure, and major maternal adverse outcomes in women with a previous cesarean with twin or singleton pregnancies. STUDY DESIGN:This was a multicenter retrospective cohort study between the years 1996 and 2...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Cahill A,Stamilio DM,Paré E,Peipert JP,Stevens EJ,Nelson DB,Macones GA

    更新日期:2005-09-01 00:00:00

  • Perinatal observations in a high-risk population managed without intrapartum fetal pH studies.

    abstract::Intrapartum fetal scalp blood pH studies remain controversial in obstetrics. Electronic fetal monitoring, by contrast, has achieved nearly uniform acceptance. Controlled comparative studies from one institution are unlikely to provide adequate numbers. Intrapartum fetal monitoring is used consistently at our instituti...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Perkins RP

    更新日期:1984-06-01 00:00:00

  • Second-look operations in ovarian cancer.

    abstract::One hundred eighty-six patients with epithelial tumors of the ovary who were managed at the M. D. Anderson Hospital and Tumor Institute underwent an exploratory operation ("second-look" operation) to assess the status of the cancer. Fifty-eight patients were found to have no evidence of disease (NED) and chemotherapy ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Schwartz PE,Smith JP

    更新日期:1980-12-15 00:00:00

  • Are you a lumper or a splitter?

    abstract::The current goal of evidence-based medicine, prospective therapeutic interventions in large numbers of patients, may not always reach an accurate conclusion. Individual variations in genetic characteristics need to be acknowledged and taken into account in the analysis. Some women with recurrent vulvo-vaginal candiosi...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审


    authors: Ledger WJ,Witkin SS

    更新日期:2006-11-01 00:00:00

  • Differences in practice patterns between obstetricians and family physicians: use of serum screening.

    abstract:OBJECTIVE:Our purpose was to compare the use of the Iowa Expanded Serum Screening program (maternal serum alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol) by obstetricians and family physicians. STUDY DESIGN:A registry was used to identify all obstetricians (160) and family physicians (404) w...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Yankowitz J,Howser DM,Ely JW

    更新日期:1996-04-01 00:00:00

  • Intrauterine administration of methyl cyanoacrylate as an outpatient method of permanent female sterilization.

    abstract::Results are presented of multicenter studies on the intrauterine delivery of 0.6 ml methyl cyanoacrylate with the FEMCEPT device (BioNexus Inc., Raleigh, North Carolina) for the purpose of causing permanent obstruction of the fallopian tubes. The studies included 1279 women and were conducted under several different p...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Richart RM,Neuwirth RS,Goldsmith A,Edelman DA

    更新日期:1987-04-01 00:00:00

  • Adherence to practice guidelines is associated with reduced referral times for patients with ovarian cancer.

    abstract:BACKGROUND:Patients with ovarian cancer tend to receive the highest quality of care at high-volume cancer centers with gynecological oncologists. However, the care that they receive prior to gynecological oncology consult has not been examined. We investigated the quantity and quality of care given to patients with ova...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Boac BM,Xiong Y,Apte SM,Wenham RM,Shahzad MM,Munroe DG,Lancaster JM,Chon HS

    更新日期:2018-04-01 00:00:00

  • Seventy-one quadruplet pregnancies: management and outcome.

    abstract::This article reviews the epidemiology, management, and outcome of 71 quadruplet pregnancies that occurred between 1980 and 1989. A study of detailed medical questionnaires and medical records revealed that 67 (94%) of the pregnancies followed ovulation induction therapy. A majority of the pregnancies were diagnosed by...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Collins MS,Bleyl JA

    更新日期:1990-06-01 00:00:00

  • Variations in red blood cell proton T1 relaxation times that correspond to menstrual cycle changes.

    abstract::A study was made of the relationship of proton T1 relaxation times and stage of the menstrual cycle. Preliminary data show that these indicators of red blood cell hydration status may be useful as objective markers of premenstrual tension. ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Rosenthal JS,Strauss A,Minkoff LA,Winston A

    更新日期:1985-12-01 00:00:00

  • Multiplexed analysis of circulating cell-free fetal nucleic acids for noninvasive prenatal diagnostic RHD testing.

    abstract:OBJECTIVE:The objective of the study was the evaluation of a novel multiplex assay to detect fetal Rh blood group D-antigen gene (RHD) loci in maternal plasma from RhD-negative, pregnant women. STUDY DESIGN:An RHD genotyping assay was designed to detect exons 4, 5, 7, and 10 and RHDΨ (pseudogene) of the RHD gene along...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Tynan JA,Angkachatchai V,Ehrich M,Paladino T,van den Boom D,Oeth P

    更新日期:2011-03-01 00:00:00

  • Cefotetan-induced anaphylaxis.

    abstract::Three cases of anaphylactic reactions associated with the use of intravenous cefotetan as surgical prophylaxis for cesarean section (two cases) and transabdominal hysterectomy (one case) are presented. Comprehensive review of these cases revealed no evidence of lot-specific association, drug-drug interaction, or metho...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Bloomberg RJ

    更新日期:1988-07-01 00:00:00

  • Cigarette smoking, use of oral contraceptives, and myocardial infarction.

    abstract::The excess risk of nonfatal myocardial infarction among users of oral contraceptives observed in England and Wales can be explained in terms of the high proportion of smokers in the study population. Among nonsmokers, the relative risk associated with the use of oral contraceptives is estimated to be 2 to 1, which is ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Jain AK

    更新日期:1976-10-01 00:00:00

  • Profet, profits, and proof: do nausea and vomiting of early pregnancy protect women from "harmful" vegetables?

    abstract:OBJECTIVE:The purpose of this research was to test a widely publicized theory that nausea and vomiting of pregnancy protects women from ingesting certain vegetables and other foods that produce congenital anomalies and other adverse outcomes of pregnancy. STUDY DESIGN:The theory was tested with use of data on dietary ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章


    authors: Brown JE,Kahn ES,Hartman TJ

    更新日期:1997-01-01 00:00:00

  • The preterm prediction study: failure of midtrimester cervical sialidase level elevation to predict subsequent spontaneous preterm birth.

    abstract:OBJECTIVE:Our objective was to determine any associations among midtrimester cervical fluid sialidase activity, bacterial vaginosis, and subsequent spontaneous preterm birth. STUDY DESIGN:In this nested case-control study all patients (n = 126) with spontaneous preterm birth at <35 weeks' gestation and selected contro...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Andrews WW,Tsao J,Goldenberg RL,Hauth JC,Mercer B,Iams J,Meis P,Moawad A,Das A,Van Dorsten PJ,Caritis SN,Thurnau G,Miodovnik M,Roberts J,McNellis D

    更新日期:1999-05-01 00:00:00

  • Adherence to hormonal contraception among women veterans: differences by race/ethnicity and contraceptive supply.

    abstract:OBJECTIVE:The objective of the study was to assess the adherence to hormonal contraception (pill, patch, ring, or injectable) among women veterans and examine the relationships between race/ethnicity and the months of contraceptive supply dispensed with contraceptive adherence. STUDY DESIGN:We conducted a retrospectiv...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Borrero S,Zhao X,Mor MK,Schwarz EB,Good CB,Gellad WF

    更新日期:2013-08-01 00:00:00

  • Effect of oxytocin antagonists on the activation of human myometrium in vitro: atosiban prevents oxytocin-induced desensitization.

    abstract:OBJECTIVE:Our purpose was to investigate whether the sensitivity of myometrial cells to oxytocin is affected by prolonged exposure to oxytocin antagonists. STUDY DESIGN:Tissue slices or cultured myometrial cells were exposed to peptides in vitro. Myometrial activation was studied by measuring the formation of inositol...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Phaneuf S,Asbóth G,MacKenzie IZ,Melin P,López Bernal A

    更新日期:1994-12-01 00:00:00

  • Vaginal birth after cesarean among women with gestational diabetes.

    abstract:OBJECTIVE:We sought to determine the pregnancy and infant outcomes of women with gestational diabetes who attempted vaginal birth after previous cesarean delivery. STUDY DESIGN:We conducted a retrospective cohort study to compare women with gestational diabetes with matched control subjects without diabetes who attemp...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Coleman TL,Randall H,Graves W,Lindsay M

    更新日期:2001-05-01 00:00:00

  • Rapid presumptive diagnosis of gonococcal cervicitis by the limulus lysate assay.

    abstract::In an evaluation of the limulus lysate assay (LLA) as a method for detecting gonococcal endotoxin in cervical exudates diluted 1:800, positive LLA results were obtained from 17 of 18 patients (94%) with culture-proved gonococcal cervicitis, and negative results were obtained from 22 of 22 patients (100%) with culture-...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Spagna VA,Prior RB,Perkins RL

    更新日期:1980-07-01 00:00:00

  • Predictors of occult neoplasia in women undergoing risk-reducing salpingo-oophorectomy.

    abstract:OBJECTIVE:The purpose of this study was to define the rate of neoplasia in prophylactic surgical specimens with the use of a careful surgical and pathologic protocol in a prospective study of high-risk women who were undergoing risk-reducing salpingo-oophorectomy. Outcomes of interest were neoplasia that was identified...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Lamb JD,Garcia RL,Goff BA,Paley PJ,Swisher EM

    更新日期:2006-06-01 00:00:00

  • The effect of magnesium sulfate tocolysis on the fetal biophysical profile.

    abstract::The biophysical profile has proved to be a valuable tool for the assessment of fetal well-being, independent of gestational age. Magnesium sulfate is commonly used as a tocolytic agent, yet relatively little is known about its effects on the biophysical activities of the fetus. To investigate the effects of magnesium ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章


    authors: Peaceman AM,Meyer BA,Thorp JA,Parisi VM,Creasy RK

    更新日期:1989-09-01 00:00:00