Abstract：
:This study was undertaken to evaluate the catecholamine response of the fetal rat to insulin-induced hypoglycemia in the mother. Twenty-four Sprague-Dawley rats at day 21 of gestation were used. Hypoglycemia was induced with regular insulin; then at timed intervals, the rats were anesthetized with pentobarbital. When the rats were completely unresponsive, the abdomen was opened, the fetuses were exteriorized, and fetal blood was obtained by sectioning the axillary vessels. Maternal blood was obtained from the vena cava. Plasma glucose was measured by the glucose oxidase technique. Norepinephrine, epinephrine, and dopamine were measured by radioenzymatic assay. Maternal animals demonstrated a fall in glucose to a nadir of 23 +/- 0.7 mg/dl (mean +/- SEM) and a significant rise in plasma epinephrine to a maximum of 2,548.0 +/- 1,071.2 pg/ml. Fetal glucose fell to a nadir of 23.8 +/- 3.3 mg/dl (mean +/- SEM) and fetal catecholamines demonstrated a rapid significant rise: norepinephrine rose to a maximum of 5,077.3 +/- 932.6 pg/ml; epinephrine rose to a maximum of 4,295.8 +/- 538.9 pg/ml; dopamine rose to a maximum of 869 +/- 203.3 pg/ml. The fetal correlation coefficients were r = -0.56 (p less than 0.01) for plasma glucose compared to norepinephrine and r = -0.58 (p less than 0.01) for plasma glucose compared to epinephrine. The maternal correlation coefficient for plasma glucose compared to epinephrine was r = -0.54 (p less than 0.01). These data demonstrate that the near-term fetal rat is able to respond significantly to hypoglycemia with a rapid output of catecholamines.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Phillippe M,Kitzmiller JLdoi
10.1016/0002-9378(81)90317-3subject
Has Abstractpub_date
1981-02-15 00:00:00pages
407-15issue
4eissn
0002-9378issn
1097-6868pii
0002-9378(81)90317-3journal_volume
139pub_type
杂志文章abstract：BACKGROUND:Epithelial ovarian cancer prognosis is improved by the presence of intratumoral CD3 + T cells, which are known to produce interferon-gamma. We therefore speculated that interferon-gamma expression in ovarian cancer-infiltrating T-lymphocytes might cause better prognosis. PATIENTS AND METHODS:Reverse transcr...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2004.05.007
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:Women in the postpartum period are at high risk for complications from influenza. Pharmacokinetic data of oseltamivir phosphate in postpartum women, however, are lacking. STUDY DESIGN:Seven healthy patients within 48 hours of delivery were recruited. Each woman received 75 mg of oseltamivir phosphate. Plasma...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2011.01.056
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:This study investigates the association of allelic variation in angiogenic pathway genes and preeclampsia. STUDY DESIGN:Data for cases with preeclampsia and term control subjects were collected prospectively. Maternal DNA was extracted, and 124 tagging single nucleotide polymorphisms in 6 genes (vascular end...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2010.01.040
更新日期：2010-05-01 00:00:00
abstract：:Cigarette smoking is associated with many health hazards, ranging from lung cancer to low infant birth weight. In the United States in 1994, 23.1% of all women and 14.6% of pregnant women smoked. Few physicians ask their patients about smoking, although minimal effort by physicians could help many smokers to quit. Thi...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1053/ob.1996.v175.a74919
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVES:This study aimed to determine whether administration of lamivudine to pregnant women with chronic hepatitis B in the third trimester is a cost-effective strategy in preventing perinatal transmission. STUDY DESIGN:We developed a decision analysis model to compare the cost-effectiveness of 2 management strate...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2012.06.001
更新日期：2012-09-01 00:00:00
abstract：:Pregnancy and peripartum/perinatal periods are characterized by significant biologic as well as psychosocial processes and changes that influence the 2 individuals at focus (mother and fetus), as well as their interactions with the immediate environment. Multiple intertwined pathologic pregnancy processes (hormonal, b...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.ajog.2005.02.103
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:The purposes of this study were to examine endothelial nitric oxide synthase expression in endothelial cells and to determine whether the inhibition of endothelial nitric oxide synthase could impair endothelial barrier function in preeclampsia. STUDY DESIGN:Messenger RNA and protein expression for endothelia...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2003.09.049
更新日期：2004-03-01 00:00:00
abstract：:There is a widespread recrudescence of venereal disease. The possible reasons for this are discussed. Each disease is then considered from the viewpoints of clinical course, diagnosis, and treatment. Treatment failures are discussed in detail, immunity is covered, and recommendations for the future conclude the presen...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(76)90905-4
更新日期：1976-05-01 00:00:00
abstract：:We report a case of splenic rupture after cesarean delivery for abruptio placentae. The diagnosis was not suspected until a laparotomy was performed. Diagnosis and management were complicated by disseminated intravascular coagulation and renal failure. The importance of early diagnosis and management modalities are di...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(95)90199-x
更新日期：1995-07-01 00:00:00
abstract：:Our subjects were 32 patients whose old complete perineal lacerations were repaired in the 10 hospitals in the South Hampton Roads Metropolitan area over a 20-year period. The layer technique of repair (26 patients) and the Warren flap procedure (6 patients) were used. Function improved in 24 of 26 patients (92%) with...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(88)80053-x
更新日期：1988-09-01 00:00:00
abstract：:Retrospective review of 457 breech deliveries failed to reveal a significant improvement in neonatal mortality and morbidity rates for those delivered by cesarean section vs. vaginal delivery. A slight but insignificant improvement in salvage was found for the 1,000 to 1,500 gram weight category when delivery was by c...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(79)90638-0
更新日期：1979-07-15 00:00:00
abstract：OBJECTIVE:Our purpose was to study the effects of long-term treatment with magnesium sulfate on hypoxic-ischemic brain damage in newborn rats. STUDY DESIGN:Seven-day-old rat pups (n = 120) were exposed to unilateral carotid artery ligation and 2 hours of hypoxia (8% oxygen in 92% nitrogen). Neuronal loss was evaluated...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2001.108343
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:Closure of the fetal ductus arteriosus, which is usually due to nonsteroidal antiinflammatory agents, may be detrimental. Therefore prenatal and postnatal clinical and echocardiographic findings in four human fetuses with spontaneous ductus arteriosus occlusion are reported. STUDY DESIGN:Echocardiographic an...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(96)70317-4
更新日期：1996-03-01 00:00:00
abstract：:Since late 1979 to early 1980, when toxic shock syndrome achieved notoriety, a substantial body of data has demonstrated that vaginal Staphylococcus aureus infections, particularly those occurring during menstruation, account for most cases of toxic shock syndrome in women of reproductive age. Among those patients wit...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9378(12)90734-6
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:Intra-amniotic infection or inflammation (IAI) is common in early preterm birth and associated with significant neonatal lung morbidity due to fetal exposure to pro-inflammatory cytokines and infectious organisms. Amniotic fluid interleukin-8 (IL-8), a pro-inflammatory cytokine, was previously correlated wit...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2020.12.1214
更新日期：2021-01-04 00:00:00
abstract：:To determine whether hormone analysis could be used for accurate determination of fetal sex, we measured testosterone (T) and follicle-stimulating hormone (FSH) in 130 amniotic fluid samples at midgestation. The mean unconjugated T in amniotic fluid of 73 patients carrying male fetuses was 202 pg. per milliliter (95 p...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(77)90034-5
更新日期：1977-07-01 00:00:00
abstract：:Peripheral blood mononuclear cells from patients with preeclampsia were enumerated by means of monoclonal anti-T-cell antibodies. The percentage of total T cells was significantly decreased in this group of patients, as compared with normal term pregnant women. The low proportion of T cells was due to a proportional r...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(83)90018-2
更新日期：1983-11-01 00:00:00
abstract：:Experiments were conducted with 11 chronically catheterized fetal sheep to determine the effects of norepinephrine on the distribution of umbilical venous blood through the ductus venosus, and within the fetal liver. An intraumbilical infusion of 1.1 microgram/kg/min of norepinephrine increased placental blood flow bu...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(80)90388-9
更新日期：1980-05-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to test the hypothesis that cocaine alters placental prostaglandin production in vitro. STUDY DESIGN:Placentas were obtained from healthy women (n = 6) after normal vaginal delivery at term. Placental explants (300 mg) were incubated in duplicate at 37 degrees C in the presenc...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(94)90015-9
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:The integrity of the pelvic autonomic nervous system is essential for proper bowel, bladder, and sexual function. OBJECTIVE:The purpose of this study was to characterize the anatomic path of the pelvic autonomic system and to examine relationships to clinically useful landmarks. STUDY DESIGN:Detailed disse...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2016.12.002
更新日期：2017-04-01 00:00:00
abstract：:In a previous study, it was suggested that the presence of a grade III placenta correlates 100% with a mature lecithin/sphingomyelin (L/S) ratio and may replace amniocentesis in confirming fetal lung maturity. In this study that hypothesis was tested in 563 pregnancies. All patients underwent amniocentesis and simulta...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(82)90478-1
更新日期：1982-08-15 00:00:00
abstract：OBJECTIVE:The purpose of this study was to correlate the diagnosis of endometriosis on the basis of visualization at laparoscopy with the pathologic diagnosis. STUDY DESIGN:A prospective study of 44 patients undergoing laparoscopy for the evaluation of chronic pelvic pain was carried out. All areas suggestive of endom...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2001.115747
更新日期：2001-06-01 00:00:00
abstract：:A severely Rh-isoimmunized pregnancy is described in which an intrauterine transfusion of blood was given by the intravascular route directly into an umbilical vessel. Fetoscopy was not used, and the procedure was performed percutaneously under direct ultrasound visualization. ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(86)90613-7
更新日期：1986-03-01 00:00:00
abstract：:There are two major approaches to the prophylaxis for adhesions: chemical methods (e.g., dextran) and barrier methods. Theoretically, dextran prevents the formation of adhesions by a surface-coating or hydroflotation effect, whereas the barrier methods either prevent the formation of or mask adhesions by covering and ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(82)90018-7
更新日期：1982-08-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate prospectively the Centers for Disease Control recommendations for the treatment of gonococcal infection in pregnancy. STUDY DESIGN:One hundred sixty-one women who were referred with probable endocervical gonorrhea underwent pretreatment endocervical, anal, and oral c...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/mob.2001.117662
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:The objective of the study was to compare the efficacy and outcomes of 2 vs 1 stitch at the time of cervical cerclage placement for preterm birth prevention. STUDY DESIGN:This was a retrospective cohort study of women with singleton gestation undergoing history- or ultrasound-indicated transvaginal cervical ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2012.11.039
更新日期：2013-03-01 00:00:00
abstract：:The regional distribution of cerebral blood flow was assessed in eight control and eight morphometrically growth-retarded fetal lambs to determine whether perfusion patterns within the cerebral circulation are altered in this model of intrauterine growth retardation. Growth retardation was induced by repetitive emboli...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(84)90460-5
更新日期：1984-12-01 00:00:00
abstract：:Scientific evidence indicates that improving a woman's health before pregnancy will improve pregnancy outcomes. However, for many years, our efforts have focused primarily on prenatal care and on caring for infants after birth. The concept of preconception care has been identified repeatedly as a priority for improvin...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2008.08.059
更新日期：2008-12-01 00:00:00
abstract：:A retrospective analysis was made of Rh-sensitized patients delivered of their babies at Duke University Medical Center during a 24 year period. Records of 202 obstetric patients representing 280 sensitized pregnancies from a pool of 39,910 deliveries were analyzed for past obstetric history, blood group information, ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(81)90083-1
更新日期：1981-08-15 00:00:00
abstract：:The purpose of this review is to assimilate relevant experimental and clinical information available on selective estrogen receptor modulators with respect to their potential use as agents to improve women's health in the postmenopausal years. In addition, the mechanisms of action of these drugs are outlined. Selectiv...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9378(99)70285-1
更新日期：1999-03-01 00:00:00
