当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > A randomized trial that compared oral cefixime and intramuscular ceftriaxone for the treatment of gonorrhea in pregnancy.

A randomized trial that compared oral cefixime and intramuscular ceftriaxone for the treatment of gonorrhea in pregnancy.

Abstract：

OBJECTIVE:The purpose of this study was to evaluate prospectively the Centers for Disease Control recommendations for the treatment of gonococcal infection in pregnancy. STUDY DESIGN:One hundred sixty-one women who were referred with probable endocervical gonorrhea underwent pretreatment endocervical, anal, and oral cultures for Neisseria gonorrhoeae. The women were randomly assigned to receive ceftriaxone 125 mg intramuscularly or cefixime 400 mg orally. Treatment was open and in a 1:1 distribution. There were 95 evaluable patients. The tests of cure cultures were performed 4 to 10 days after treatment. RESULTS:Eighty-six women (91%) had endocervical infection; 39 women (41%) had anal infection, and 11 women (12%) had pharyngeal infection. Fifty of 95 women (53%) had concomitant endocervical chlamydial infection. The overall efficacy was 91 of 95 subjects (95.8%; 95% CI, 89.6%-98.8%). Ceftriaxone was effective in 41 of 43 cases (95%; 95% CI, 84.2%-99.4%), and cefixime was effective in 50 of 52 cases (96%; 95% CI, 86.8%-99.5%). No significant difference was noted in the overall efficacy or by site of infection. Three of the 4 women who experienced treatment failures admitted to unprotected intercourse before their test of cure culture. CONCLUSION:Both intramuscular ceftriaxone 125 mg and oral cefixime 400 mg appear to be effective for the treatment of gonococcal infection in pregnancy.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Ramus RM,Sheffield JS,Mayfield JA,Wendel GD Jr

doi

10.1067/mob.2001.117662

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

629-32

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(01)19706-1

journal_volume

185

pub_type

临床试验,杂志文章,随机对照试验

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Lack of relationship between prolactin and adrenal steroidogenesis in the ovine fetus.

    abstract：:The role of fetal prolactin (PRL) as a fetal adrenotropic hormone was investigated in eight chronically catheterized fetal lambs. Catheters were placed for measurement of plasma prolactin (PRL), cortisol (F), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A). Daily (9 AM) ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(81)90320-3

    authors： Takahashi K,Auletta F,Tseng HY,Scommegna A,Burd LI

    更新日期：1981-02-15 00:00:00

  • Reproductive coercion: uncloaking an imbalance of social power.

    abstract：:Reproductive coercion involves behavior that interferes with contraceptive and pregnancy choices of women and occasionally men. This includes birth control sabotage (intentional destruction of a woman's chosen method of contraception), pregnancy pressure (behaviors to coerce pregnancy against one's wishes), and pregna...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2015.08.045

    authors： Park J,Nordstrom SK,Weber KM,Irwin T

    更新日期：2016-01-01 00:00:00

  • Multiple pregnancy rate and embryo number transferred during in vitro fertilization.

    abstract：OBJECTIVE:Our goal was to achieve a good pregnancy rate after in vitro fertilization; more than one embryo, if available, is transferred to the uterine cavity. This is a recognition of the low implantation rates of embryos from in vitro fertilization. A consequence of this can be high-order multiple implantation with o...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70197-2

    authors： Elsner CW,Tucker MJ,Sweitzer CL,Brockman WD,Morton PC,Wright G,Toledo AA

    更新日期：1997-08-01 00:00:00

  • Measurement of amniotic fluid volume: accuracy of ultrasonography techniques.

    abstract：OBJECTIVE:Our purpose was to determine amniotic fluid volume by the dye-dilution technique and compare it with the amniotic fluid index, largest vertical pocket, and two-diameter pocket (defined as vertical x horizontal of the largest vertical pocket). STUDY DESIGN:This prospective study involved 40 women undergoing a...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(92)91734-r

    authors： Magann EF,Nolan TE,Hess LW,Martin RW,Whitworth NS,Morrison JC

    更新日期：1992-12-01 00:00:00

  • Factors associated with an increased risk of prevalent and incident grade III cervical intraepithelial neoplasia and invasive cervical cancer among women with Papanicolaou tests classified as grades I or II cervical intraepithelial neoplasia.

    abstract：OBJECTIVE:Women with Papanicolaou tests classified as cervical intraepithelial neoplasia grade I or II are treated conservatively in many countries. However, these women are at an increased risk of having underlying prevalent and incident grade III cervical intraepithelial neoplasia and invasive cancer. This study was ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.118918

    authors： Petry KU,Böhmer G,Iftner T,Davies P,Brummer O,Kühnle H

    更新日期：2002-01-01 00:00:00

  • Retroperitoneal mucinous cystadenoma.

    abstract：:Twelve cases of retroperitoneal mucinous cystadenoma or mucinous cystadenocarcinoma in women have been reported in the literature. We report an additional case. The histogenesis of mucinous cystadenomas and mucinous cystadenocarcinomas in the retroperitoneum is not clear, but that these lesions may arise from teratoma...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90201-9

    authors： Pennell TC,Gusdon JP Jr

    更新日期：1989-05-01 00:00:00

  • The bladder neck support prosthesis: a nonsurgical approach to stress incontinence in adult women.

    abstract：OBJECTIVE:Our purpose was to evaluate a vaginal device designed to support the bladder neck in women with urinary stress incontinence. STUDY DESIGN:Thirty-two physically active incontinent women underwent urodynamic evaluation and maintained a bladder diary before enrollment and after 4 weeks of device use. Outcome me...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-9378(94)90470-7

    authors： Davila GW,Ostermann KV

    更新日期：1994-07-01 00:00:00

  • Cytogenetics of aborters and abortuses.

    abstract：:783 aborters and 430 abortuses were studied in a prospective cytogenetic survey which attempted to link chromosome abnormalities and history of recurrent abortion. 425 female and 358 male spontaneous aborters and their 430 abortuses (310 were karotyped) showed 4 women and 2 men as balanced translocation carriers (3 R...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(78)90470-2

    authors： Kajii T,Ferrier A

    更新日期：1978-05-01 00:00:00

  • Can women without visible pubococcygeal muscle in MR images still increase urethral closure pressures?

    abstract：OBJECTIVE:The purpose of this study was to determine if the ability to increase maximum urethral closure pressure (MUCP) with a pelvic muscle contraction is impaired in women without pubococcygeal muscle (PCM). STUDY DESIGN:This was a cross-sectional study of continent women comparing those with (n=28) and those witho...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2004.03.082

    authors： Miller JM,Umek WH,Delancey JO,Ashton-Miller JA

    更新日期：2004-07-01 00:00:00

  • Alternatives to mifepristone regimens for medical abortion.

    abstract：:Alternatives to regimens with mifepristone and a prostaglandin analog for medical abortion emerged because of the need for accessible, effective, and safe options in areas of the world where mifepristone was unavailable. Studies of oral or intramuscular methotrexate combined with misoprostol have demonstrated complete...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1067/mob.2000.107949

    authors： Pymar HC,Creinin MD

    更新日期：2000-08-01 00:00:00

  • Gonorrhea and female infertility in rural Uganda.

    abstract：:We studied sociocultural and medical factors in the Teso District in eastern Uganda and the Ankole District in western Uganda to discover the cause of the low and high fertility rates in these respective districts. The findings related to gonorrhea in women are presented in this article. Gonococcal cervicitis and clin...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(80)91083-2

    authors： Arya OP,Taber SR,Nsanze H

    更新日期：1980-12-01 00:00:00

  • Baboon corpus luteum oxytocin: an intragonadal peptide modulator of luteal function.

    abstract：:Oxytocin concentrations were determined in baboon (Papio anubis) corpora lutea, and the effect of oxytocin on dispersed luteal cell progesterone production was evaluated. Oxytocin concentrations increased significantly from an early luteal phase value of 2.1 +/- 1.1 ng/gm to a peak concentration of 18.1 +/- 4.3 ng/gm ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90089-0

    authors： Khan-Dawood FS,Huang JC,Dawood MY

    更新日期：1988-04-01 00:00:00

  • Diabetic ketoacidosis and insulin resistance with subcutaneous terbutaline infusion: a case report.

    abstract：:Diabetic ketoacidosis may occur in women treated with intravenous beta-sympathomimetic agents for tocolysis. We describe diabetic ketoacidosis and transient severe insulin resistance in a woman with diabetes who was treated with subcutaneous terbutaline infusion. Subcutaneous terbutaline infusion may precipitate trans...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)91185-f

    authors： Tibaldi JM,Lorber DL,Nerenberg A

    更新日期：1990-08-01 00:00:00

  • Decreased very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid expression in placentas from preeclamptic pregnancies.

    abstract：OBJECTIVE:Our purpose was to investigate the levels of very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid expression in placentas obtained from normal pregnant women at various gestational stages and from patients with preeclampsia. STUDY DESIGN:The relative level of expressio...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)70105-9

    authors： Murata M,Kodama H,Goto K,Hirano H,Tanaka T

    更新日期：1996-12-01 00:00:00

  • Improving patient understanding of preeclampsia: a randomized controlled trial.

    abstract：OBJECTIVE:We developed a standardized educational tool to inform women about preeclampsia. The objective of this study was to assess whether exposure to this tool led to superior understanding of the syndrome. STUDY DESIGN:This was a randomized controlled trial in which 120 women were assigned to (1) a newly developed...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2012.03.006

    authors： You WB,Wolf MS,Bailey SC,Grobman WA

    更新日期：2012-05-01 00:00:00

  • Improved detection of fetal cells from maternal blood with polymerase chain reaction.

    abstract：OBJECTIVE:The objective was to test the reliability of new deoxyribonucleic acid primers that have previously been used very efficiently by this laboratory with amniolysate samples to amplify a 248 bp Y-specific, repeated sequence from maternal blood during pregnancy. STUDY DESIGN:Blood samples were obtained from 50 w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(94)70312-4

    authors： Adkison LR,Andrews RH,Vowell NL,Koontz WL

    更新日期：1994-03-01 00:00:00

  • To the Point: a prescription for well-being in medical education.

    abstract：:This article is from the "To The Point" series prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee. The purpose of this review was to provide an overview of the importance of well-being in medical education. A literature search was performed by a Reference L...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2019.05.012

    authors： Hopkins L,Morgan H,Buery-Joyner SD,Craig LB,Everett EN,Forstein DA,Graziano SC,Hampton BS,McKenzie ML,Page-Ramsey SM,Pradhan A,Bliss S,Undergraduate Medical Education Committee, Association of Professors of Gynecology and Obstetr

    更新日期：2019-12-01 00:00:00

  • Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories.

    abstract：:Mid-trimester abortion was successfully induced in 70 of 71 patients by administration of vaginal PGE2 suppositories. The one patient who failed to abort with this method was pregnant in the blind horn of a duplex uterus. The mean abortion time for the successful inductions was 11.88 hours. Multiparous patients aborte...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90353-1

    authors： Lauersen NH,Secher NJ,Wilson KH

    更新日期：1975-08-15 00:00:00

  • Neurological control of fetal heart rate in 20 cases of anencephalic fetuses.

    abstract：:Fetal heart rate (FHR) is influenced by the central nervous system, cardiac automatism, biochemical factors, etc. Changes in FHR were correlated with the anatomic defect in autopsy material from 20 anencephalic infants, and, on this basis, the following hypotheses were formed, subject to later experimental proof. (1) ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(84)90199-6

    authors： Terao T,Kawashima Y,Noto H,Inamoto Y,Lin TY,Sumimoto K,Maeda M

    更新日期：1984-05-15 00:00:00

  • Effect of prolactin in an experimental model of the ovarian hyperstimulation syndrome.

    abstract：:In the rabbit model of the ovarian hyperstimulation syndrome, animals given ovine prolactin with human menopausal gonadotropins (hMGs), as compared to animals receiving hMGs alone, demonstrated an increase in the formation of ascitic fluid, a decrease in mean plasma estradiol, and an increase in the mean plasma proges...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90690-7

    authors： Leung P,Ho Yuen B,Moon YS

    更新日期：1983-04-01 00:00:00

  • Combined gonadotropin-releasing hormone analog and exogenous gonadotropins for ovulation induction in infertile women: efficacy related to ovarian function assessment.

    abstract：:The ovarian function of infertile women with normal menstrual rhythm was investigated by daily plasma hormone (estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone) analyses throughout the menstrual cycle, and patients were diagnosed as showing a subnormal profile of progesterone in the early...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(88)80088-7

    authors： Fleming R,Haxton MJ,Hamilton MP,Conaghan CJ,Black WP,Yates RW,Coutts JR

    更新日期：1988-08-01 00:00:00

  • Influence of ionizing radiation on fetoplacental growth in mice.

    abstract：:The effects of single doses of 60Co whole-body irradiation were studied in about 600 inbred primiparous Swiss-Webster mice on gestational day 9, 10, 11, or 12. The embryos and their placentas were weighted from day 13 to 18. A reference model surveyed the response of the conceptus to varying doses. A significant reduc...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90889-3

    authors： Philippe JV

    更新日期：1975-11-15 00:00:00

  • INTERGROWTH-21st vs customized birthweight standards for identification of perinatal mortality and morbidity.

    abstract：BACKGROUND:The recently published INTERGROWTH-21st Project international population standard for newborn size is intended for global use, but its ability to identify small infants at risk of adverse outcomes in a general obstetric population has not been reported. OBJECTIVE:The objective of the study was to compare ad...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2015.10.931

    authors： Anderson NH,Sadler LC,McKinlay CJD,McCowan LME

    更新日期：2016-04-01 00:00:00

  • Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. I. Correlation of receptor expression with prognostic factors in patients with ovarian cancer.

    abstract：:Previous studies in breast and bladder cancer have suggested that epidermal growth factor receptor is expressed by only a proportion of cancers and is associated with poor clinical outcome. We used a monoclonal antibody specifically reactive with the extracellular domain of the epidermal growth factor receptor to loca...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(11)80044-x

    authors： Berchuck A,Rodriguez GC,Kamel A,Dodge RK,Soper JT,Clarke-Pearson DL,Bast RC Jr

    更新日期：1991-02-01 00:00:00

  • Prenatal diagnosis of placental steroid sulfatase deficiency.

    abstract：:Placental steroid sulfatase deficiency is an unusual cause of low estriol production during pregnancy. Its importance lies in the differentiation of this disorder from the more ominous fetal defects that result in low estriol levels. Serum free estriol levels were found to be low or absent in a 25-year-old gravida 3, ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(76)90526-3

    authors： Braunstein GD,Zeil FH,Allen A,Van de Velde R,Wade ME

    更新日期：1976-11-15 00:00:00

  • Long-term observations of cervical cancer.

    abstract：:A consecutive series of approximately 1100 patients, treated for cancer of the cervix over a span of 45 years, presents an increasingly favorable stage distribution. Emergence of exfoliative cytology as a diagnostic technique accelerates allocation of new patients to Stage I. Cumulative rates of dying from cervical ca...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(87)90063-9

    authors： Arneson AN,Kao MS

    更新日期：1987-03-01 00:00:00

  • Serial noninvasive evaluation of cardiovascular hemodynamics during pregnancy.

    abstract：:M-mode echocardiography, in combination with electrocardiography and phonocardiography, has been used to measure pulmonary capillary pressure as well as other cardiac functions. Serial hemodynamic evaluations by use of this technique were performed in seven healthy pregnant women in the recumbent position. Each patien...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(87)90146-3

    authors： Mashini IS,Albazzaz SJ,Fadel HE,Abdulla AM,Hadi HA,Harp R,Devoe LD

    更新日期：1987-05-01 00:00:00

  • Survival after multimodality treatment for stage IIIC endometrial cancer.

    abstract：OBJECTIVE:Our purpose was to review our results of multimodality treatment of lymph node metastasis in endometrial cancer (stage IIIC). STUDY DESIGN:All patients underwent surgical staging for endometrial cancer with complete pelvic and aortic lymphadenectomy. All macroscopic nodal metastases were resected. Patients w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2001.115225

    authors： Katz LA,Andrews SJ,Fanning J

    更新日期：2001-05-01 00:00:00

  • The effect of magnesium sulfate on fetal heart rate parameters: A randomized, placebo-controlled trial.

    abstract：OBJECTIVE:We sought to determine the effect of magnesium sulfate on fetal heart rate baseline value, variability, and acceleration-deceleration pattern. STUDY DESIGN:Normal, nonlaboring pregnant patients at >30 weeks' gestation were recruited. Baseline fetal heart rate monitoring for 1 hour was performed. After an 800...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-9378(99)70093-1

    authors： Hallak M,Martinez-Poyer J,Kruger ML,Hassan S,Blackwell SC,Sorokin Y

    更新日期：1999-11-01 00:00:00

  • Fetal heart rate and survival of the very premature newborn.

    abstract：OBJECTIVE:Our purpose was to study the likelihood of survival of infants who are born before 28 weeks of gestation and to examine the influence of fetal heart rate findings on neonatal death. STUDY DESIGN:In this retrospective study, we analyzed the mortality rate of infants at 2 months of age as a function of various...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.126291

    authors： Ayoubi JM,Audibert F,Vial M,Pons JC,Taylor S,Frydman R

    更新日期：2002-10-01 00:00:00