The effect of norepinephrine on blood flow through the fetal liver and ductus venosus.

Abstract:

:Experiments were conducted with 11 chronically catheterized fetal sheep to determine the effects of norepinephrine on the distribution of umbilical venous blood through the ductus venosus, and within the fetal liver. An intraumbilical infusion of 1.1 microgram/kg/min of norepinephrine increased placental blood flow but did not alter the proportion of this flow that was diverted through the ductus venosus. Under control conditions the umbilical flow to the fetal liver was preferentially distributed to the left side and accounted for 80% of the total hepatic blood flow. Flow through the hepatic artery was negligible. Norepinephrine reduced portal flow but also reduced the asymmetric distribution of hepatic umbilical blood flow by greatly increasing the perfusion of the right side of the fetal liver.

journal_name

Am J Obstet Gynecol

authors

Zink J,van Petten GR

doi

10.1016/0002-9378(80)90388-9

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

71-7

issue

1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(80)90388-9

journal_volume

137

pub_type

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