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Cerebral injury in monochorionic twins with selective intrauterine growth restriction and/or birthweight discordance.

Abstract：

OBJECTIVE:The objective of the study was to study the incidence of severe cerebral injury in monochorionic (MC) twins with selective intrauterine growth restriction (sIUGR) and/or birthweight discordance. STUDY DESIGN:All MC twin pregnancies with 2 liveborn twins were included in the study. We excluded all cases with twin-to-twin transfusion syndrome (TTTS). Sequential cranial ultrasound scans were performed in all MC twin infants. RESULTS:A total of 117 MC twin pairs were included in the study. The sIUGR of at least 1 fetus was found in 50 twin pregnancies (43%), and birthweight discordance of 25% or greater occurred in 26 twin pregnancies (22%). The overall incidence of severe cerebral injury was 3% (6/218). The incidence of severe cerebral injury in infants from twin pregnancies with and without sIUGR was 2% (2/94) and 3% (4/124), respectively (P = .62). The incidence of severe cerebral injury in infants with and without birthweight discordance was 0% (0/48) and 4% (6/170), respectively (P = .19). CONCLUSION:The incidence of severe cerebral injury in MC twin pregnancies not complicated by TTTS with 2 liveborn twins is low. No association could be demonstrated with sIUGR or intertwin birthweight discordance of 25% or greater.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Lopriore E,Slaghekke F,Vandenbussche FP,Middeldorp JM,Walther FJ,Oepkes D

doi

10.1016/j.ajog.2008.06.008

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

628.e1-5

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(08)00618-2

journal_volume

199

pub_type

杂志文章

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