当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Predictors of occult neoplasia in women undergoing risk-reducing salpingo-oophorectomy.

Predictors of occult neoplasia in women undergoing risk-reducing salpingo-oophorectomy.

Abstract：

OBJECTIVE:The purpose of this study was to define the rate of neoplasia in prophylactic surgical specimens with the use of a careful surgical and pathologic protocol in a prospective study of high-risk women who were undergoing risk-reducing salpingo-oophorectomy. Outcomes of interest were neoplasia that was identified in surgical specimens and clinical outcomes of women who were undergoing risk-reducing salpingo-oophorectomy. We hypothesized that older age and having a BRCA1 mutation would be predictors for tubal or ovarian neoplasia and that a careful surgical and pathologic protocol would lead to a low rate of subsequent primary peritoneal cancer. STUDY DESIGN:A prospective tissue and research database enrolled patients who underwent risk-reducing salpingo-oophorectomy for prevention of ovarian cancer. Clinical and pathologic data were extracted for those patients after the initiation of a defined surgical and pathologic protocol in 1999. RESULTS:One hundred thirteen women met the high-risk criteria; 40 of the women (45%) who were tested had a deleterious mutation in BRCA1, and 22 women (25%) had a mutation in BRCA2. Seven women had ovarian or tubal neoplasia (6.2%). One woman had occult endometrial cancer. Age > or =45 years and having a BRCA1 or BRCA2 mutation were significant predictors of occult neoplasia. Two patients with neoplasia that was identified at risk-reducing salpingo-oophorectomy experienced recurrence. Three patients with BRCA1 mutations have subsequent new diagnoses of breast cancer. No patients had primary peritoneal cancer after risk-reducing salpingo-oophorectomy. CONCLUSION:Age > or =45 years and mutations in BRCA1 or BRCA2 predict occult neoplasia in women who undergo risk-reducing salpingo-oophorectomy. A thorough pathologic and surgical protocol at the time of risk-reducing salpingo-oophorectomy may improve the risk of subsequent primary peritoneal cancer.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Lamb JD,Garcia RL,Goff BA,Paley PJ,Swisher EM

doi

10.1016/j.ajog.2006.03.006

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

1702-9

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(06)00329-2

journal_volume

194

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Postpartum intrauterine device insertion and postpartum tubal sterilization in the United States.

    abstract：OBJECTIVE:The purpose of this study was to estimate US rates of postpartum intrauterine device (IUD) insertion and postpartum tubal sterilization. STUDY DESIGN:Data from the 2001-2008 Nationwide Inpatient Sample were used to identify delivery hospitalizations with IUD insertion or tubal sterilization procedure codes. ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2011.08.004

    authors： Whiteman MK,Cox S,Tepper NK,Curtis KM,Jamieson DJ,Penman-Aguilar A,Marchbanks PA

    更新日期：2012-02-01 00:00:00

  • The fetoplacental pressor effects of low-dose acetylsalicylic acid and angiotensin II in the ex vivo cotyledon model.

    abstract：OBJECTIVE:Our purpose was to investigate perfusion pressure changes ex vivo induced by angiotensin II on fetoplacental vasculature pretreated with low-dose acetylsalicylic acid. STUDY DESIGN:Two cotyledons from each of 12 placentas were perfused. The intervillous space of one cotyledon was infused with acetylsalicylic...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70021-8

    authors： Napolitano PG,Hoeldtke NJ,Moore KH,Calhoun BC,Christensen ED,Markenson GR,Hume RF Jr

    更新日期：1997-11-01 00:00:00

  • The pattern of labor preceding uterine rupture.

    abstract：OBJECTIVE:We sought to characterize the labor of women attempting trial of labor after cesarean (TOLAC) who experience uterine rupture. STUDY DESIGN:We conducted a secondary analysis of a nested case-control study of women attempting TOLAC. Women experiencing uterine rupture (cases) were compared to 2 reference groups...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2012.06.028

    authors： Harper LM,Cahill AG,Roehl KA,Odibo AO,Stamilio DM,Macones GA

    更新日期：2012-09-01 00:00:00

  • Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables.

    abstract：OBJECTIVE:This study aimed to compare the effects on hemostasis variables of a contraceptive vaginal ring with those of an oral contraceptive. STUDY DESIGN:Twenty-three and 22 healthy premenopausal women were randomized to the contraceptive vaginal ring (150 microg Nestorone and 15 microg ethinyl estradiol) or Stediri...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2005.12.007

    authors： Rad M,Kluft C,Ménard J,Burggraaf J,de Kam ML,Meijer P,Sivin I,Sitruk-Ware RL

    更新日期：2006-07-01 00:00:00

  • Fetal subcutaneous scalp PO2 and abnormal heart rate during labor.

    abstract：:Intrapartum fetal heart rate and subcutaneous scalp PO2 were continuously measured with a combined electrocardiogram-PO2 needle electrode in 34 patients. The incidence of fetal heart rate abnormalities increased significantly with decreasing subcutaneous PO2, from 0.8% of the 10-minute periods in which subcutaneous PO...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(85)90476-4

    authors： Aarnoudse JG,Huisjes HJ,Gordon H,Oeseburg B,Zijlstra WG

    更新日期：1985-11-01 00:00:00

  • The preterm prediction study: failure of midtrimester cervical sialidase level elevation to predict subsequent spontaneous preterm birth.

    abstract：OBJECTIVE:Our objective was to determine any associations among midtrimester cervical fluid sialidase activity, bacterial vaginosis, and subsequent spontaneous preterm birth. STUDY DESIGN:In this nested case-control study all patients (n = 126) with spontaneous preterm birth at <35 weeks' gestation and selected contro...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(99)70609-5

    authors： Andrews WW,Tsao J,Goldenberg RL,Hauth JC,Mercer B,Iams J,Meis P,Moawad A,Das A,Van Dorsten PJ,Caritis SN,Thurnau G,Miodovnik M,Roberts J,McNellis D

    更新日期：1999-05-01 00:00:00

  • Serum p53 antibody as a diagnostic marker of high-risk endometrial cancer.

    abstract：OBJECTIVE:The purpose of this study was to investigate the diagnostic impact of preoperative serum p53 antibody (S-p53 Ab) in patients with endometrial cancer. STUDY DESIGN:A hospital-based series of 67 patients, comprising 58 endometrioid adenocarcinomas (EA) and 9 serous adenocarcinomas (SA) between 1998-2002 were i...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2007.04.033

    authors： Yamazawa K,Shimada H,Hirai M,Hirashiki K,Ochiai T,Ishikura H,Shozu M,Isaka K

    更新日期：2007-11-01 00:00:00

  • Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes.

    abstract：:We used the minimal model technique to obtain concurrent measurements of whole-body insulin sensitivity and pancreatic B-cell responsiveness to glucose during the third trimester of pregnancy. Insulin sensitivity in normal pregnant women (n = 8) was reduced to only one third that of a group of nonpregnant women (n = 7...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)91306-w

    authors： Buchanan TA,Metzger BE,Freinkel N,Bergman RN

    更新日期：1990-04-01 00:00:00

  • Expression of genes involved in placental glucose uptake and transport in the nonobese diabetic mouse pregnancy.

    abstract：OBJECTIVE:Maternal diabetes alters placental glucose metabolism and maternofetal glucose transport. The purpose of this study was to determine whether genes involved in placental glucose uptake and transport were concomitantly altered, resulting in the observed changes in the state of maternal diabetes. STUDY DESIGN:B...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(94)90154-6

    authors： Devaskar SU,Devaskar UP,Schroeder RE,deMello D,Fiedorek FT Jr,Mueckler M

    更新日期：1994-11-01 00:00:00

  • Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast.

    abstract：OBJECTIVES:The purpose of our study was to establish an in vitro tissue culture system to study eicosanoid metabolism in first-trimester trophoblastic tissue. Thromboxane A2, a potent vasoconstrictor, and prostacyclin, a potent vasodilator, were analyzed to evaluate their production in early pregnancy. STUDY DESIGN:Tr...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(12)80036-6

    authors： Diss EM,Gabbe SG,Moore JW,Kniss DA

    更新日期：1992-10-01 00:00:00

  • Human chorionic gonadotropin, prolactin, estriol, and dehydroepiandrosterone sulfate concentrations in cord blood of premature and term newborn infants: relationship to the sex of the neonate.

    abstract：:Although the composition of human chorionic gonadotropin, prolactin, estriol, and dehydroepiandrosterone sulfate in the umbilical cord blood has been studied, less information is available on the effect of fetal sex on the cord blood concentrations. We assayed these hormones in cord blood from 405 newborn infants deli...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(87)90291-2

    authors： Yuen BH,Mincey EK

    更新日期：1987-02-01 00:00:00

  • Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women.

    abstract：OBJECTIVE:We hypothesize that genetic variations (single nucleotide polymorphisms-SNPs) in the tumor necrosis factor-alpha (TNF-alpha), TNF receptors (TNFRI and TNFRII), interleukin-6 (IL-6) and IL-6 receptor (IL-6R) genes predict high-risk status for spontaneous preterm birth (sPTB) in European-American women. In this...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2006.03.059

    authors： Menon R,Velez DR,Simhan H,Ryckman K,Jiang L,Thorsen P,Vogel I,Jacobsson B,Merialdi M,Williams SM,Fortunato SJ

    更新日期：2006-06-01 00:00:00

  • Integration of genetics and ultrasonography in prenatal diagnosis: just looking is not enough.

    abstract：OBJECTIVE:There has been a gradual shift of the focus of prenatal diagnosis from genetics to ultrasonography. We assessed our primary genetics approach to determine what would be missed without the genetics component. STUDY DESIGN:We evaluated referral indications for patients with normal and abnormal prenatal finding...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)70230-2

    authors： Evans MI,Hume RF Jr,Johnson MP,Treadwell MC,Krivchenia EL,Zador IE,Sokol RJ

    更新日期：1996-06-01 00:00:00

  • Immunoregulatory activity in supernatants from cultures of normal human trophoblast cells of the first trimester.

    abstract：:Supernatants from isolated trophoblast cell cultures (trophoblastic fluid) derived from first-trimester human placentas were assessed for immunoregulatory activity. Trophoblastic fluid at different days of culture consistently inhibited the blast transformation of allogenic lymphocytes. This suppressor effect had no a...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90540-1

    authors： Sanyal MK,Brami CJ,Bischof P,Simmons E,Barnea ER,Dwyer JM,Naftolin F

    更新日期：1989-08-01 00:00:00

  • Benefit and burden in the Dutch cytology-based vs high-risk human papillomavirus-based cervical cancer screening program.

    abstract：BACKGROUND:In 2017, the Dutch cervical cancer screening program had replaced the primary cytology-based screening with primary high-risk human papillomavirus-based screening, including the opportunity to participate through self-sampling. Evaluation and balancing benefit (detection of high-grade cervical intraepithelia...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2020.08.026

    authors： Loopik DL,Koenjer LM,Siebers AG,Melchers WJG,Bekkers RLM

    更新日期：2020-08-13 00:00:00

  • Experience of a controlling or threatening partner among mothers with persistent symptoms of depression.

    abstract：OBJECTIVE:We evaluated the prevalence of symptoms of maternal depression (SMD) that continue beyond the postpartum period and the association between persistent SMD and reporting a controlling or threatening partner. STUDY DESIGN:We combined data from a survey of mothers 2-6 months after delivery and its 2-year follow...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2009.04.025

    authors： Blabey MH,Locke ER,Goldsmith YW,Perham-Hester KA

    更新日期：2009-08-01 00:00:00

  • Maternal and perinatal long-chain fatty acids: possible roles in preterm birth.

    abstract：OBJECTIVE:We conducted a case-control study to evaluate whether maternal and fetal omega-3 and omega-6 essential fatty acid status play possible roles in the pathogenesis of preterm birth. STUDY DESIGN:Essential fatty acid status in blood and trophoblast tissues was measured in (1) women and their newborns with sponta...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70620-3

    authors： Reece MS,McGregor JA,Allen KG,Harris MA

    更新日期：1997-04-01 00:00:00

  • Avoiding serious infections associated with abdominal hysterectomy: a meta-analysis of antibiotic prophylaxis.

    abstract：OBJECTIVE:Our objective was to determine whether the use of preoperative antibiotics prevents serious infections associated with total abdominal hysterectomy. STUDY DESIGN:We identified 25 randomized controlled trials of antibiotic prophylaxis that used rigorous protocols. We performed meta-analysis and cumulative met...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,meta分析

    doi：10.1016/0002-9378(93)90266-l

    authors： Mittendorf R,Aronson MP,Berry RE,Williams MA,Kupelnick B,Klickstein A,Herbst AL,Chalmers TC

    更新日期：1993-11-01 00:00:00

  • Risk factors for maternal and fetal outcome in pregnancy complicated by Ebstein anomaly.

    abstract：OBJECTIVE:The goal of the study was to examine risks in pregnancy in patients with Ebstein anomaly. STUDY DESIGN:Data were examined retrospectively for 13 patients (27 pregnancies, 21 live births) with Ebstein anomaly during pregnancy who were treated at our institution from 1985 to 2011. The associated anomalies in t...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2013.07.005

    authors： Katsuragi S,Kamiya C,Yamanaka K,Neki R,Miyoshi T,Iwanaga N,Horiuchi C,Tanaka H,Yoshimatsu J,Niwa K,Ikeda T

    更新日期：2013-11-01 00:00:00

  • Atrial natriuretic peptide: a vasodilator of the fetoplacental circulation?

    abstract：:Paired maternal and fetal atrial natriuretic peptide concentrations were measured in 62 percutaneous umbilical blood samplings performed principally for the assessment and treatment of rhesus isoimmunization. Pretransfusion fetal atrial natriuretic peptide levels were significantly higher than maternal atrial natriure...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90419-r

    authors： Kingdom JC,Ryan G,Whittle MJ,McNay MB,Bowman AW,Doyle J,Connell JM

    更新日期：1991-10-01 00:00:00

  • Umbilical and placental vessels: modifications of their mechanical properties in preeclampsia.

    abstract：OBJECTIVES:Our objective in this study was to assess the basic mechanical properties of umbilical and chorionic vessels of placentas delivered after both normal and preeclamptic pregnancies. STUDY DESIGN:Placentas were selected when the parturient women were admitted to the delivery room. Normal pregnancy (n = 17) was...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(11)90795-9

    authors： Bertrand C,Duperron L,St-Louis J

    更新日期：1993-05-01 00:00:00

  • Clinical significance of fetal heart rate patterns during labor. V. Variable decelerations.

    abstract：:Among a large series of high-risk patients who had direct electronic monitoring, 330 fetuses presented "variable" decelerations and 598 had no decelerations. Among those with variable decelerations, there were 18 who presented such associated fetal heart rate (FHR) alterations as tachycardia, fixed baseline, and slow ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(78)80014-3

    authors： Cibils LA

    更新日期：1978-12-01 00:00:00

  • Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios.

    abstract：OBJECTIVE:We tested the hypothesis that preterm delivery in women with twins or polyhydramnios is associated with enhanced expression and activity of cyclooxygenase type 2 in the amnion. STUDY DESIGN:We obtained amniotic tissue samples from women undergoing preterm delivery complicated by either twins or polyhydramnio...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2001.108076

    authors： Leguizamón G,Smith J,Younis H,Nelson DM,Sadovsky Y

    更新日期：2001-01-01 00:00:00

  • Outcome comparison of in vitro fertilization treatment with highly purified subcutaneous follicle-stimulating hormone (Fertinex, a urofollitropin) versus intramuscular menotropins.

    abstract：OBJECTIVE:The aim of this study was to investigate various outcome measures of stimulation with highly purified subcutaneous follicle-stimulating hormone (Fertinex, a urofollitropin) compared with first- and second-generation urinary human menopausal gonadotropin standards (Pergonal, Metrodin). STUDY DESIGN:Retrospect...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(98)70356-4

    authors： Crain JL,Wiemer KE,Steuerwald N,Young ED

    更新日期：1998-08-01 00:00:00

  • Assessment of diagnostic aspiration curettage as an outpatient procedure.

    abstract：:Aspiration curettage proved acceptable to patients and medical staff when incorporated into a busy outpatient practice. The diagnostic reliability of curettings obtained was shown to be 93.5 per cent accurate. In all patients where mucus only is obtained, where symptoms persist or recur, or when aspiration curettage i...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90622-5

    authors： Liu DT,Melville HA,Measday B,Melcher D

    更新日期：1975-05-01 00:00:00

  • Relationships between prenatal medical and nutritional measures, pregnancy outcome, and early infant development in an urban poverty setting. I. The role of nutritional intake.

    abstract：:Repeated nutritional assessments were made on 118 low-income women who registered at an urban hospital clinic prior to the twenty-eighth week of pregnancy and then on 122 comparable women who were provided with protein-mineral supplementation. Demographic and background information were obtained. Medical assessments w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90487-1

    authors： Osofsky HJ

    更新日期：1975-12-01 00:00:00

  • Does maternal age at retrieval influence the implantation potential of euploid blastocysts?

    abstract：BACKGROUND:Age-related decline in reproductive potential is mainly due to the increased incidence of aneuploidy. Furthermore, 2 recent studies have shown that euploid embryos of older women may have a lower implantation potential compared to those of younger women, suggesting that aging might compromise embryos beyond ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2018.11.1103

    authors： Irani M,Zaninovic N,Rosenwaks Z,Xu K

    更新日期：2019-04-01 00:00:00

  • Report of fourteen cases of nonimmune hydrops fetalis in association with hemorrhagic endovasculitis of the placenta.

    abstract：:Hemorrhagic endovasculitis of the placenta is a distinct vasodestructive process of unknown cause that has been associated with perinatal morbidity and mortality. A relationship between nonimmune hydrops fetalis and hemorrhagic endovasculitis has not been previously described. At a large teaching hospital, six cases o...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90445-w

    authors： Novak PM,Sander CM,Yang SS,von Oeyen PT

    更新日期：1991-10-01 00:00:00

  • Postmortem microfocus computed tomography for noninvasive autopsies: experience in >250 human fetuses.

    abstract：BACKGROUND:Noninvasive imaging autopsy alternatives for fetuses weighing <500 grams are limited. Microfocus computed tomography has been reported as a viable option in small case series with the potential to avoid an invasive autopsy. Implementation of postmortem microfocus computed tomography in a large cohort as part...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2020.07.019

    authors： Shelmerdine SC,Simcock IC,Hutchinson JC,Guy A,Ashworth MT,Sebire NJ,Arthurs OJ

    更新日期：2021-01-01 00:00:00

  • A rapid visual test for predicting fetal lung maturity.

    abstract：:A rapid bedside test has been devised that enables an untrained observer to predict (p less than 0.001) when amniotic fluid will be greater than or equal to 0.15 at an optical density of 650 nm, lecithin/sphingomyelin ratio will be greater than or equal to 2.0, or when phosphatidylglycerol will be present. By a visual...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90366-y

    authors： Sbarra AJ,Chaudhury A,Cetrulo CL,Mittendorf R,Shakr C,Kennison R,Jones J,Kennedy J Jr

    更新日期：1991-11-01 00:00:00