Preterm twins: what threshold of birth weight discordance heralds major adverse neonatal outcome?

Abstract:

OBJECTIVE:This study was undertaken to establish the optimal threshold of birth weight discordance for prediction of adverse outcome in liveborn, non-malformed preterm twins. STUDY DESIGN:We accessed a cohort of twin gestations for the period 1990 through 2000 delivered at less than 37.0 weeks' gestation. Adverse neonatal outcome was defined as stillbirth or occurrence of major morbidities. RESULTS:A total of 335 twin gestations (670 twins) were included, of which 104 (31%) experienced adverse neonatal outcome. The average birth weight discordance was 12.4% +/- 10.6% versus 19.4% +/- 14.8% in those with good versus adverse outcome (P < .001). Birth weight discordance was a significant predictor of adverse neonatal outcome that was independent of gestational age at delivery, small for gestational age, and chorionicity. Receiver operating characteristic curve analysis suggested that optimal thresholds of birth weight discordance for clinical use should take into account gestational age. CONCLUSION:Birth weight discordance is an independent predictor of adverse neonatal outcome in liveborn, non-malformed preterm twins.

journal_name

Am J Obstet Gynecol

authors

Vergani P,Locatelli A,Ratti M,Scian A,Pozzi E,Pezzullo JC,Ghidini A

doi

10.1016/j.ajog.2004.05.053

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1441-5

issue

4

eissn

0002-9378

issn

1097-6868

pii

S000293780400537X

journal_volume

191

pub_type

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