Alpha-fetoprotein, human placental lactogen, and pregnancy-specific beta 1-glycoprotein in pregnant women who drink: relation to fetal alcohol syndrome.

Abstract:

:To determine the usefulness of the assays of maternal serum alpha-fetoprotein, human placental lactogen, and pregnancy-specific beta 1-glycoprotein in prenatal diagnosis of fetal alcohol syndrome, these proteins were followed in 35 problem drinkers (greater than 100 gm of ethanol weekly) and in 14 abstinent women throughout gestation. Thirteen women gave birth to infants with fetal alcohol syndrome, and these women had low levels of alpha-fetoprotein and pregnancy-specific beta 1-glycoprotein but levels of human placental lactogen were normal. Low alpha-fetoprotein correctly predicted fetal alcohol syndrome in 59% with a relative risk of 2.46. Low pregnancy-specific beta 1-glycoprotein predicted fetal alcohol syndrome in 56%, and a relative risk was 3.29. Low alpha-fetoprotein and pregnancy-specific beta 1-glycoprotein may reflect primary or secondary effects of ethanol abuse in pregnancy and appear to be useful in predicting fetal alcohol syndrome.

journal_name

Am J Obstet Gynecol

authors

Halmesmäki E,Autti I,Granström ML,Heikinheimo M,Raivio KO,Ylikorkala O

doi

10.1016/0002-9378(86)90286-3

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

598-602

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(86)90286-3

journal_volume

155

pub_type

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