Maternal serum alpha-fetoprotein screening: further consideration of low-volume testing.

Abstract:

:Unrecognized assay drift that may occur during low-volume (fewer than 500 specimens per week) maternal serum alpha-fetoprotein testing could result in either underestimation or overestimation of the number of pregnant women who are at increased risk of fetal malformations and genetic anomalies. Quality control software programs that incorporate the use of a multirule Shewhart chart are designed to detect assay drift. Careful selection of quality control sera for inclusion in analytic assays and appropriate application of a multirule quality control procedure to values that are obtained on these control materials should detect assay drift, regardless of the volume of patients' specimens in the run.

journal_name

Am J Obstet Gynecol

authors

Strickland DM,Butzin CA,Wians FH Jr

doi

10.1016/0002-9378(91)90502-i

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

711-4

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(91)90502-I

journal_volume

164

pub_type

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