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Transdermal estrogen reduces vascular resistance and serum cholesterol in postmenopausal women.

Abstract：

OBJECTIVE:Our aim was to compare the effects of transdermal versus oral estrogens on vascular resistance index, mean arterial pressure, serum lipid concentrations, norepinephrine, and left ventricular structure. STUDY DESIGN:Ten postmenopausal women received transdermal estradiol (0.05 mg/d) plus cyclic oral progesterone for 6 months. Responses were compared with those of 23 women receiving oral conjugated estrogens (0.625 mg/d) plus cyclic progesterone and with those of 9 subjects receiving placebo in a concurrent randomized trial. We assessed the vascular resistance index and the mean arterial pressure at rest and during behavioral stressors. RESULTS:Oral and transdermal estrogen significantly decreased the vascular resistance index, mean arterial pressure, norepinephrine, and total and low-density lipoprotein cholesterol to a similar extent. Changes in the vascular resistance index and mean arterial pressure were equally evident at rest and during stress. Although both treatments reduced left ventricular mass (-4% to -6%) and relative wall thickness (-3% to -5%), these changes were not statistically significant. CONCLUSIONS:Equivalent reductions in vascular resistance index, norepinephrine, mean arterial pressure, and cholesterol were observed with transdermal and oral estrogens. Future studies comparing novel hormone regimens with oral hormone replacement therapy should include multiple risk markers to allow better assessment of their potential impact on coronary artery health.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

West SG,Hinderliter AL,Wells EC,Girdler SS,Light KC

doi

10.1067/mob.2001.112104

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

926-33

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(01)14387-5

journal_volume

184

pub_type

杂志文章

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