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Effect of age, parity, and smoking on pregnancy outcome: a population-based study.

Abstract：

OBJECTIVES:The purpose of our study was to investigate the combined interactive effects of maternal age, parity, and smoking on pregnancy outcome. STUDY DESIGN:This was a population-based Swedish study (n = 538,829). RESULTS:Multiple logistic regression analysis showed that the smoking-related effect on the relative increase in the odds ratio of low birth weight and preterm delivery was significantly greater among multiparous patients than nulliparous; among multiparas, smoking increased the odds ratios for low birth weight and preterm delivery by 2.4 and 1.6; the corresponding relative increases in the odds ratios among nulliparas were 1.7 and 1.1, respectively. With advancing maternal age there was a smoking-related relative increase in the odds ratios for small-for-gestational-age births. Moreover, the age effect on the relative increase of low birth weight, preterm delivery, and small-for-gestational-age births was greater among nulliparas than multiparas. CONCLUSIONS:Older smokers are at an especially high risk for small-for-gestational-age births, and parous smokers are at an especially high risk for low birth weight and preterm delivery.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Cnattingius S,Forman MR,Berendes HW,Graubard BI,Isotalo L

doi

10.1016/s0002-9378(12)90878-9

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

16-21

issue

1 Pt 1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(12)90878-9

journal_volume

168

pub_type

杂志文章

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